Endocrinology
KEYWORDS
Diabetes Mellitus, Glucagon, Amino Acid Metabolism, Regulation of Cell Proliferation, Molecular Genetics, Animal Model
HEAD
CONTACT
| hayashiy◎riem.nagoya-u.ac.jp (Please send a message after replacing "◎" mark with "@" mark. ) |
OUTLINE
Our laboratory focuses on the development of preventive and therapeutic approaches for endocrine disorders, including diabetes mellitus, using genetically modified animal models.
RESEARCH PROJECTS
Homozygous glucagon-GFP knock-in mice lack all the peptide derived from proglucagon, such as glucagon, GLP-1 and GLP-2. Using this iunique animal model we generated, we are analyzing regulation of amino acid metabolism by glucagon, and proliferation of pancreatic islet endocrine cells regulated by humoral factors and/or through neural networks.
BIBLIOGRAPHY
2024
- Hayashi Y. Advances in basic research on glucagon and alpha cells. Diabetology International, 2024.
2018
- Hayashi Y, Seino Y. Regulation of amino acid metabolism and alpha-cell proliferation by glucagon. Journal of Diabetes Investigation. 2018.
