Laboratories

Sports Medicine

KEYWORDS

  • Exercise therapy
  • Physical training
  • Skeletal muscle
  • Glucose metabolism
  • Insulin resistance
  • Diabetes mellitus
  • Obesity

HEAD

KOIKE, Teruhiko

Professor

Researchers

CONTACT

Email iga-ryu◎t.mail.nagoya-u.ac.jp (Please send a message after replacing "◎" mark with "@" mark. )

OUTLINE

Insulin resistance is a major pathological condition associated with lifestyle-related diseases such as obesity, diabetes and hypertension. Insulin resistance also can play a critical role in aging. Our laboratory aims to clarify the mechanism associated with insulin resistance and its countermeasure and to contribute to the prevention of lifestyle-related diseases. In particular, focusing on the prevention by exercise and nutritional interventions, we do human studies, in vivo animal studies, and molecular biological studies. Recently we also started research on glucose and energy metabolism in the central nervous system.

RESEARCH PROJECTS

1. Basic and clinical studies on insulin resistance

In addition to the role of insulin resistance in glucose metabolism, we have been studying the role of insulin resistance in skeletal muscle and brain in recent years. Skeletal muscle, one of the main regulatory organs of glucose, has been gaining more attention as the impact of sarcopenia (age-related skeletal muscle loss), which is the main factor of physical weakness in the elderly. Healthy muscle is critical for QOL of the elderly. Age-related cognitive decline and increase of dementia are also serious concerns in an aging society. The prevention and treatment of sarcopenia and cognitive decline by exercise and nutrition therapy, which can optimize insulin resistance, are highly expected. With this background, using glucose metabolism, skeletal muscle quality and quantity, and chronic inflammation in the brain as indicators, we aim to find the way to decrease the risk of sarcopenia and cognitive decline or dementia.

2. Regulatory mechanisms of glucose metabolism and energy balance

Energy balance is regulated by central nervous system. While obesity, which is the cause of lifestyle-related diseases, is spreading all over the world at pandemic level, effective medical treatments have not yet been established. Therefore, elucidation of the mechanisms of obesity and the establishment of obesity treatment is expected. Our research focus is the mechanisms by which a high-fat diet impairs both glucose and energy metabolism, and the regulatory mechanisms of glucose metabolism by central nervous system as well. Especially, we are focused on protein tyrosine phosphatase 1B（PTP1B）that is the regulatory factor of insulin receptor signaling, leptin receptor signaling and inflammation. We use various genetically modified mice so that we can elucidate the regulatory mechanisms of glucose metabolism and energy balance.

BIBLIOGRAPHY

2025
  1. Fu L, Sugiyama M, Kamal S, Ide T, Takeda T, Kuno M, Takagi H, Koike T, Arima H, Banno R: Effects of Combination Treatment with Leptin and Liraglutide on Glucose Metabolism in Insulin-Dependent Diabetic Mice. Int J Mol Sci. 2025 May 11;26(10):4595. doi: 10.3390/ijms26104595.
  2. Kawaguchi Y, Hodai Y, Naito S, Kondo Y, Tsumura T, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Arima H, Hagiwara D: Reticulon 4 reflects endoplasmic reticulum stress in arginine vasopressin neurons. Neuroreport. 2025 Jul 2;36(10):540-546. doi:10.1097/WNR.0000000000002174.
  3. Iwama S, Kobayashi T, Izuchi T, Suzuki K, Murase T, Ando M, Handa T, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Mori S, Sano T, Akamatsu S, Akiyama M, Ishii M, Arima H: Combined PD-1 and CTLA-4 blockade increases the risks of multiple pituitary hormone deficiency and isolated adrenocorticotropic deficiency: A prospective study.Endocrinol Metab (Seoul). 2025 Jun;40(3):459-468. doi: 10.3803/EnM.2024.2180.
  4. Hirose T, Takagi H, Kuno M, Sasaki T, Taki K, Ito Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Suga H, Banno R, Arima H: Dapagliflozin increased pancreatic beta cell proliferation and insulinogenic index in mice fed a high-fat and high-sodium chloride diet. Biochem Biophys Res Commun. 2025 Feb 16;749:151364. doi: 10.1016/j.bbrc.2025.151364.
  5. Tsumura T, Hagiwara D, Naito S, Kondo Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Arima H: Compensatory mechanisms underlying arginine vasopressin regulation in transient polyuria during pregnancy. Peptides. 2025 Feb;184:171352. doi: 10.1016/j.peptides.2025.171352.
  6. Katayama K, Shiozawa K, Ishida K, Banno R, Kinoshita A, Iwamoto E, Ogoh S: Inhibition of sympathetic vasomotor outflow during low-intensity leg cycling is attenuated in healthy older females. J Appl Physiol (1985). 2025 May 1;138(5):1133-1142. doi: 10.1152/japplphysiol.01008.2024.
  7. Miyata T, Hagiwara D, Ashida R, Naito S, Kawaguchi Y, Handa T, Kobayashi T, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Matsumoto M, Urakubo H, Ohno N, Arima H: Phagophores originate from endoplasmic reticulum membranes in vasopressin neurons in a mouse model of familial neurohypophysial diabetes insipidus. Cell Tissue Res. 2025 Nov;402(2):139-144. doi: 10.1007/s00441-025-04013-w.
  8. Handa T, Hagiwara D, Maeda R, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Kuwatsuka Y, Arima H: The time of the hypertonic saline infusion test for the diagnosis of AVP deficiency can be shortened with LC-MS/MS. J Clin Endocrinol Metab. 2025 Jul 30:dgaf432. doi: 10.1210/clinem/dgaf432.
  9. Handa T, Onoue T, Maeda R, Mizutani K, Suzuki K, Kobayashi T, Miyata T, Sugiyama M, Hagiwara D, Iwama S, Suga H, Banno R, Arima H: Guidance on energy intake based on resting energy expenditure and physical activity: Effective for reducing body weight in patients with obesity. Nutrients. 2025 Jan 7;17(2):202. doi: 10.3390/nu17020202
  10. Kamal S, Gou Y, Tsuzuki T, Fu L, Yamada T, Banno T, Koike T: D-Allulose ameliorates fructose-induced skeletal muscle insulin resistance via regulation of ectopic lipid accumulation independent of body weight changes. Nutrients. 2025 Jun 19;17(12):2050. doi: 10.3390/nu17122050. PMID: 40573161; PMCID: PMC12196061.
2024
  1. Suzuki K, Kobayashi T, Izuchi T, Otake K, Ando M, Handa T, Miyata T, Sugiyama M, Onoue T, Hagiwara D, Suga H, Banno R, Hase T, Inoue M, Ishii M, Arima H, Iwama S: Development of pituitary dysfunction and destructive thyroiditis is associated with better survival in non-small cell lung cancer patients treated with programmed cell death-1 inhibitors: a prospective study with immortal time bias correction. Front Endocrinol (Lausanne). 2024 Nov 7;15:1490042. doi: 10.3389/fendo.2024.1490042.
  2. Sasaki T, Sugiyama M, Kuno M, Miyata T, Kobayashi T, Yasuda Y, Onoue T, Takagi H, Hagiwara D, Iwama S, Suga H, Banno R, Arima H: Voluntary exercise suppresses inflammation and improves insulin resistance in the arcuate nucleus and ventral tegmental area in mice on a high-fat diet. Physiol Behav. 2024 Dec 1;287:114703. doi: 10.1016/j.physbeh.2024.114703.
  3. Katayama K, Shiozawa K, Lee JB, Kondo H, Seo N, Ishida K, Millar PJ, Banno R, Ogoh S: Sympathoinhibition during cardiopulmonary baroreceptor loading is attenuated in older females. Am J Physiol Regul Integr Comp Physiol. 2024 Jul 1;327(1):R88-R96. doi: 10.1152/ajpregu.00109.2024.
  4. Katayama K, Shiozawa K, Lee JB, Seo N, Kondo H, Saito M, Ishida K, Millar PJ, Banno R, Ogoh S: Influence of sex on sympathetic vasomotor outflow responses to passive leg raising in young individuals. J Physiol Sci. 2024 Mar 18;74(1):19. doi: 10.1186/s12576-024-00909-4.
  5. Yamagami A, Iwama S, Kobayashi T, Zhou X, Yasuda Y, Okuji T, Ito M, Izuchi T, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Arima H: Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade. Endocr J. 2024 May 23;71(5):515-526. doi: 10.1507/endocrj.EJ23-0480.
  6. Handa T, Onoue T, Kobayashi T, Maeda R, Mizutani K, Yamagami A, Kinoshita T, Yasuda Y, Iwama S, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Azuma Y, Kasai T, Yoshioka S, Kuwatsuka Y, Arima H: Effects of Digitization of self-monitoring of blood glucose records using a mobile app and the cloud system on outpatient management of diabetes: Single-armed prospective study. JMIR Diabetes. 2024 Jan 19;9:e48019. doi: 10.2196/48019.
  7. Kobayashi T, Iwama S, Yamagami A, Izuchi T, Suzuki K, Otake K, Yasuda Y, Ando M, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Hase T, Nishio N, Mori S, Shimokata T, Sano T, Niimi K, Yoshikawa N, Akamatsu S, Ando Y, Akiyama M, Sone M, Ishii M, Arima H: Combined use of tyrosine kinase inhibitors with PD-(L)1 blockade increased the risk of thyroid dysfunction in PD-(L)1 blockade: a prospective study. Cancer Immunol Immunother. 2024 Jun 4;73(8):146. doi: 10.1007/s00262-024-03733-2.
  8. Okuji T, Iwama S, Kobayashi T, Yasuda Y, Ito M, Yamagami A, Ando M, Hase T, Shibata H, Hatta T, Zhou X, Onoue T, Kawaguchi Y, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Ando Y, Hashimoto N, Arima H: Thyroid autoantibodies at baseline predict longer survival in non-small cell lung cancer patients treated with anti-programmed cell death-1 blockade: a prospective study. Nagoya J Med Sci. 2024 Aug;86(3):452-463. doi: 10.18999/nagjms.86.3.452.
  9. Yoshiko A, Shiozawa K, Niwa S, Takahashi, H, Koike T, Watanabe K, Katayama K, Akima H: Association of skeletal muscle oxidative capacity with muscle function, sarcopenia-related exercise performance, and intramuscular adipose tissue in older adults. Geroscience. 2024 Apr;46(2):2715-2727. doi: 10.1007/s11357-023-01043-6. Epub 2023 Dec 28. PMID: 38153667; PMCID: PMC10828458.
2023
  1. Ito M, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Kobayashi T, Zhou X, Yamagami A, Onoue T, Miyata T, Sugiyama M, Hagiwara D, Suga H, Banno R, Nishikawa H, Arima H: Anti-tumor effects of anti-programmed cell death-1 antibody treatment are attenuated in streptozotocin-induced diabetic mice. Sci Rep. 2023 Apr 12;13(1):5939. doi: 10.1038/s41598-023-33049-7.
  2. Kawaguchi Y, Hagiwara D, Tsumura T, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Yasuda Y, Iwama S, Suga H, Banno R, Grinevich V, Arima H.: Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice. J Neuroendocrinol. 2023 Jan;35(1):e13223. doi: 10.1111/jne.13223.
  3. Kurimoto J, Takagi H, Miyata T, Kawaguchi Y, Hodai Y, Tsumura T, Hagiwara D, Kobayashi T, Yasuda Y, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Katsuki T, Ando F, Uchida S, Arima H: Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency. Endocr J. 2023 Mar 28;70(3):295-304. doi: 10.1507/endocrj.EJ22-0339.
  4. Hayase A, Onoue T, Kobayashi T, Wada E, Handa T, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Kuwatsuka Y, Ando M, Goto M, Arima H: Improved glycemic control after the use of flash glucose monitoring accompanied by improved treatment satisfaction in patients with non-insulin-treated type 2 diabetes: A post-hoc analysis of a randomized controlled trial. Prim Care Diabetes. 2023 Dec;17(6):575-580. doi: 10.1016/j.pcd.2023.09.009.
  5. Handa T, Onoue T, Kobayashi T, Wada E, Hayase A, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H: Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. Arch Endocrinol Metab. 2023 Mar 10;67(2):233-241. doi: 10.20945/2359-3997000000532.
2022
  1. Ito Y, Sun R, Yagimuma H, Taki K, Mizoguchi A, Kobayashi T, Sugiyama M, Onoue T, Tsunekawa T, Takagi H, Hagiwara D, Iwama S, Suga H, Konishi H, Kiyama H, Arima H, Banno R: Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin. Diabetes. 2022 Sep 1;71(9):1902-1914. doi: 10.2337/db21-0953.
  2. Kawaguchi Y, Hagiwara D, Tsumura T, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Yasuda Y, Iwama S, Suga H, Banno R, Grinevich V, Arima H: Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice. J Neuroendocrinol. 2023 Jan;35(1):e13223. doi: 10.1111/jne.13223.
  3. Kurimoto J, Takagi H, Miyata T, Kawaguchi Y, Hodai Y, Tsumura T, Hagiwara D, Kobayashi T, Yasuda Y, Sugiyama M, Onoue T, Iwama S, Suga H, Banno R, Katsuki T, Ando F, Uchida S, Arima H: Mineralocorticoids induce polyuria by reducing apical aquaporin-2 expression of the kidney in partial vasopressin deficiency. Endocr J. 2023 Mar 28;70(3):295-304. doi: 10.1507/endocrj.EJ22-0339.
  4. Wada E, Onoue T, Kinoshita T, Hayase A, Handa T, Ito M, Furukawa M, Okuji T, Kobayashi T, Iwama S, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H: Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter]. Diabetologia. 2022 Jan;65(1):252-253. doi: 10.1007/s00125-021-05610-4.
  5. Ozaki H, Suga H, Sakakibara M, Soen M, Miyake N, Miwata T, Taga S, Nagai T, Kano M, Mitsumoto K, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Iwama S, Banno R, Iguchi G, Takahashi Y, Muguruma K, Inoue H, Arima H: Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state. Sci Rep. 2022 Oct 17;12(1):17381. doi: 10.1038/s41598-022-22405-8.
  6. Handa T, Onoue T, Kobayashi T, Wada E, Hayase A, Kinoshita T, Yamagami A, Yasuda Y, Iwama S, Kawaguchi Y, Miyata T, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H: Resting energy expenditure depends on energy intake during weight loss in people with obesity: a retrospective cohort study. Arch Endocrinol Metab. 2023 Mar 10;67(2):233-241. doi: 10.20945/2359-3997000000532.
  7. Hioki M, Kanehira N, Koike T, Saito A, Shimaoka K, Sakakibara H, Oshida Y, Akima H: Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults. PLoS One. 2022 Jan 4;17(1):e0262271. doi: 10.1371/journal.pone.0262271. PMID: 34982778; PMCID: PMC8726469.
  8. Liu B, Gou Y, Tsuzuki T, Yamada T, Iida T, Wang S, Banno R, Toyoda Y, Koike T: D-Allulose improves endurance and Recovery from exhaustion in male C57BL/6J mice. Nutrients 2022.14, no. 3: 404. https://doi.org/10.3390/nu14030404
  9. Yoshiko A, Maeda H, Takahashi H, Koike T, Tanaka N, Akima H: Contribution of skeletal muscle and serum lipids to muscle contraction induced by neuromuscular electrical stimulation in older individuals. Physiol Rep. 2022 Mar;10(6):e15236. doi: 10.14814/phy2.15236. PMID: 35312173; PMCID: PMC8935638.
  10. Tsuzuki T, Suzuki R, Kajun R, Yamada T, Iida T, Liu B, Koike T, Toyoda Y, Negishi T, Yukawa K: Combined effects of exercise training and D-allulose intake on endurance capacity in mice. Physiol Rep. 2022 May;10(9):e15297. doi: 10.14814/phy2.15297. PMID: 35546434; PMCID: PMC9095992.
  11. Yoshiko A, Maeda H, Takahashi H, Koike T, Tanaka N, Akima H: Importance of skeletal muscle lipid levels for muscle function and physical function in older individuals. Appl Physiol Nutr Metab. 2022 Jun 1;47(6):649-658. doi: 10.1139/apnm-2021-0685. Epub 2022 Jul 15. PMID: 35839289.
  12. Kitagawa F, Ogawa M, Yoshiko A, Oshida Y, Koike T, Akima H, Tanaka NI: Factors related to trunk intramuscular adipose tissue content - A comparison of younger and older men. Exp Gerontol. 2022 Oct 15;168:111922. doi: 10.1016/j.exger.2022.111922. PMID: 35964898.
2021
  1. Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K: Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis. JCI Insight. 2021 Oct 22;6(20):e142464. doi: 10.1172/jci.insight.142464.
  2. Wada E, Onoue T, Kinoshita T, Hayase A, Handa T, Ito M, Furukawa M, Okuji T, Kobayashi T, Iwama S, Sugiyama M, Takagi H, Hagiwara D, Suga H, Banno R, Goto M, Arima H: Predicting non-insulin-dependent state in patients with slowly progressive insulin-dependent (type 1) diabetes mellitus or latent autoimmune diabetes in adults. Reply to Sugiyama K and Saisho Y [letter]. Diabetologia. 2022 Jan;65(1):252-253. doi: 10.1007/s00125-021-05610-4.
  3. Taki K, Takagi H, Hirose T, Sun R, Yaginuma H, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Sakano D, Kume S, Arima H: Dietary sodium chloride attenuates increased β-cell mass to cause glucose intolerance in mice under a high-fat diet. PLoS One. 2021 Mar 17;16(3):e0248065. doi: 10.1371/journal.pone.0248065.
  4. Sun R, Tsunekawa T, Hirose T, Yaginuma H, Taki K, Mizoguchi A, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Banno R, Bettler B, Arima H: GABAB receptor signaling in the caudate putamen is involved in binge-like consumption during a high fat diet in mice. Sci Rep. 2021 Sep 29;11(1):19296. doi: 10.1038/s41598-021-98590-9.
  5. Yaginuma H, Banno R, Sun R, Taki K, Mizoguchi A, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Arima H: Peripheral combination treatment of leptin and an SGLT2 inhibitor improved glucose metabolism in insulin-dependent diabetes mellitus mice. J Pharmacol Sci. 2021 Dec;147(4):340-347. doi: 10.1016/j.jphs.2021.08.010.
  6. Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Kobayashi T, Sugiyama M, Tsunekawa T, Onoue T, Takagi H, Hagiwara D, Ito Y, Iwama S, Suga H, Nagai T, Yamada K, Arima H: Glucocorticoid receptor signaling in ventral tegmental area neurons increases the rewarding value of a high-fat diet in mice. Sci Rep. 2021 Jun 18;11(1):12873. doi: 10.1038/s41598-021-92386-7.
  7. Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H: Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. J Immunother Cancer. 2021 May;9(5):e002493. doi: 10.1136/jitc-2021-002493.
  8. Siriguleng S, Koike T, Natsume Y, Jiang H, Mu L, Oshida Y: Eicosapentaenoic acid enhances skeletal muscle hypertrophy without altering the protein anabolic signaling pathway. Physiol Res 2021 70(1):55-65. doi: 10.33549/physiolres.934534.
  9. Hioki M, Kanehira N, Koike T, Saito A, Takahashi H, Shimaoka K, Sakakibara H, Oshida Y, Akima H: Effect of electromyostimulation on intramyocellular lipids of the vastus lateralis in older adults: a randomized controlled trial. BMC Musculoskelet Disord. 2021 22(1):569. doi: 10.1186/s12891-021-04456-6.
  10. Ogawa M, Tanaka N, Yoshiko A, Oshida Y, Koike T, Akima H: Relationship between physical activity time and intramuscular adipose tissue content of the thigh muscle groups of younger and older men. Sci Rep 2021 11(1):19804. doi: 10.1038/s41598-021-99126-x.
  11. Natsume Y, Yamada T, Iida T, Ozaki N, Gou Y, Oshida Y, Koike. T: Investigation of D-allulose effects on high-sucrose diet-induced insulin resistance via hyperinsulinemic-euglycemic clamps in rats. Heliyon 2021 7(9):e08013. doi: 10.1016/j.heliyon.2021.e08013.
  12. Akima H, Maeda H, Koike T, Ishida K: Effect of elbow joint angles on electromyographic activity versus force relationships of synergistic muscles of the triceps brachii. PLoS One 2021 16(6):e0252644. doi: 10.1371/journal.pone.0252644.
  13. Gou Y, Liu B, Cheng M, Yamada T, Iida T, Wang S, Banno R, Koike T:D-Allulose ameliorates skeletal muscle insulin resistance in high-fat diet-fed rats. Molecules. 2021 26(20):6310. doi: 10.3390/molecules26206310. PMID: 34684891; PMCID: PMC8539500.
2020
  1. Wada E, Onoue T, Kobayashi T, Handa T, Hayase A, Ito M, Furukawa M, Okuji T, Okada N, Iwama S, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Kuwatsuka Y, Ando M, Goto M, Arima H: Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial. BMJ Open Diabetes Res Care. 2020 Jun;8(1):e001115. doi: 10.1136/bmjdrc-2019-001115.
  2. Kasai T, Suga H, Sakakibara M, Ozone C, Matsumoto R, Kano M, Mitsumoto K, Ogawa K, Kodani Y, Nagasaki H, Inoshita N, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Iwama S, Goto M, Banno R, Takahashi J, Arima H: Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells. Cell Rep. 2020 Jan 7;30(1):18-24.e5. doi: 10.1016/j.celrep.2019.12.009.
  3. Miyata T, Hagiwara D, Hodai Y, Miwata T, Kawaguchi Y, Kurimoto J, Ozaki H, Mitsumoto K, Takagi H, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Matsumoto M, Kawakami N, Ohno N, Sakamoto H, Arima H: Degradation of mutant protein aggregates within the endoplasmic reticulum of vasopressin neurons. iScience. 2020 Oct 7;23(10):101648. doi: 10.1016/j.isci.2020.101648.
  4. Kawaguchi Y, Hagiwara D, Miyata T, Hodai Y, Kurimoto J, Takagi H, Suga H, Kobayashi T, Sugiyama M, Onoue T, Ito Y, Iwama S, Banno R, Grinevich V, Arima H: Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. Sci Rep. 2020 Nov 12;10(1):19730. doi: 10.1038/s41598-020-76839-z.
  5. Takagi H, Hagiwara D, Handa T, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Iwama S, Goto M, Suga H, Banno R, Takahashi K, Matsui S, Arima H: Diagnosis of central diabetes insipidus using a vasopressin radioimmunoassay during hypertonic saline infusion. Endocr J. 2020 Mar 28;67(3):267-274. doi: 10.1507/endocrj.EJ19-0224.
  6. Okada N, Iwama S, Okuji T, Kobayashi T, Yasuda Y, Wada E, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Hase T, Morise M, Kanda M, Yokota K, Hashimoto N, Ando M, Fujimoto Y, Nagino M, Kodera Y, Fujishiro M, Hibi H, Sone M, Kiyoi H, Gotoh M, Ando Y, Akiyama M, Hasegawa Y, Arima H: Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study. Br J Cancer. 2020 Mar;122(6):771-777. doi: 10.1038/s41416-020-0736-7.
  7. Onoue T, Goto M, Wada E, Furukawa M, Okuji T, Okada N, Kobayashi T, Iwama S, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Morishita Y, Seino Y, Suga H, Banno R, Hamada Y, Ando M, Yamamori E, Arima H: Dipeptidyl peptidase-4 inhibitor anagliptin reduces fasting apolipoprotein B-48 levels in patients with type 2 diabetes: A randomized controlled trial. PLoS One. 2020 Jan 28;15(1):e0228004. doi: 10.1371/journal.pone.0228004.
  8. Kobayashi T, Iwama S, Yasuda Y, Okada N, Okuji T, Ito M, Onoue T, Goto M, Sugiyama M, Tsunekawa T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Yokota K, Hase T, Morise M, Hashimoto N, Ando M, Fujimoto Y, Hibi H, Sone M, Ando Y, Akiyama M, Hasegawa Y, Arima H: Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study. J Immunother Cancer. 2020 Jul;8(2):e000779. doi: 10.1136/jitc-2020-000779.
  9. Yoshiko A, Katayama K, Ishida K, Ando R, Koike T, Oshida Y, Akima H: Muscle deoxygenation and neuromuscular activation in synergistic muscles during intermittent exercise under hypoxic conditions. Sci Rep 2020 10(1):295. doi:10.1038/s41598-019-57099 -y.
  10. Ogawa M, Yoshiko A, Tanaka N, Koike T, Oshida Y, Akima H: Comparing intramuscular adipose tissue on T1-weighted and two-point Dixon images. PLoS ONE 2020 15(4): e0231156.https://doi.org/10.1371/journal. pone.0231156
  11. Hioki M, Kanehira N, Koike T, Saito A, Shimaoka K, Sakakibara H, Oshida Y, Akima H: Age-related changes in muscle volume and intramuscular fat content in quadriceps femoris and hamstrings. Exp Gerontol 2020 132:110834. https://doi.org/10.1016/j.exger.2020.110834
  12. Akima H, Maeda H, Koike T, Ishida K, Ando R: Comparison of fascicle behaviors between superficial and deeper muscles of triceps brachii during isometric contractions. J. Electromyogr. Kinesiol. 2020 54:https://doi.org/10.1016/j.jelekin.2020.102452

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