‰ñ ŽóÜ“–Žž‚̏Š‘® Ž–¼iŒhÌ—ªj ˜_•¶–¼ ŽGŽ–¼ Šª†ƒy[ƒW
‘æ1‰ñ ‹ãB‘åŠwˆãŠw•”®Œ`ŠO‰È ”n“n@³–¾ Expression of 92-kD type, collagenase/gelatinase(gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin. The Journal of Clinical Investigation 92:179-185,1993
‘æ1‰ñ ‘åã‘åŠwŽ•Šw•”‘æˆê‰ð–UŠw Šâ–{@—e‘× Changes in parathiroid hormone receptors during chondrocyte cytodifferentiation. The Journal of Biological Chemistry 269:17245-17251,1994
‘æ2‰ñ ‘åã‘åŠwˆãŠw•”®Œ`ŠO‰È È–؁@”͍s Differential expression of an acidic domain in the amino-terminal propeptide of mouse pro-ƒ¿2(X1) collagen by complex alternative splicing. The Journal of Biological Chemistry 270:2372-2378,1995
‘æ2‰ñ ŽD–yˆã‰È‘åŠw®Œ`ŠO‰È ˆÉ“¡@˜a¶ Multiple forms of mouse PG-M, a large chondroitin sulfate proteoglycan generated by alternative splicing. The Journal of Biological Chemistry 270:958-965,1995
‘æ3‰ñ –¼ŒÃ‰®‘åŠwˆãŠw•”®Œ`ŠO‰È ŒI“c@˜a—m Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage : molecular cloning and sequence analysis of the mouse cDNA. Biochemical Journal 318:909-914,1996
‘æ3‰ñ “Œ‹žŽœŒb‰ïˆã‰È‘åŠw®Œ`ŠO‰È ’ҁ@”ü’qŽq Expression of c-fos gene inhibits proteoglycan synthesis in transfected chondrocyte. FEBS Letters 381:222-226
‘æ4‰ñ L“‡‘åŠwŽ•Šw•”Œûo¶‰»Šw Yan Weiqun Effects of Concannavalin A on Chondrocyte Hypertrophy and Matrix Calcification. The Journal of Biological Chemistry 272:7833-7840,1997
‘æ4‰ñ ‘åã‘åŠwŽ•Šw•”¶‰»Šw Šâ–{@Ž‘ŒÈ Bone Morphogenetic Protein Signaling Is Required for Maintenance of Differentiated Phenotype, Control of Proliferation, and Hypertrophy in Chondrocytes. The Journal of Cell Biology 140(2):409-418,1998
‘æ4‰ñ ‹ž“s‘åŠw—Տ°•a‘Ôˆã‰ÈŠw‘æ“ñ“à‰È {“c@“¹—Y Skeletal Overgrowth in transgenic Mice That Overexpress Brain Natriuretic Peptide. Proc. Natl. Acad. Sci. 95:2337-2342,1998
‘æ4‰ñ ‹ß‹E‘åŠwˆãŠw•”®Œ`ŠO‰È •Ÿ“c@Š°“ñ Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity. The Journal of Laboratory and Clinical Medicine 130:209-215,1997
‘æ5‰ñ ‹ž“s‘åŠw—Տ°•a‘Ôˆã‰ÈŠw‘æ“ñ“à‰È ”ª\“c@–¾G Natriuretic Peptide Regulation of Endochondral Ossification. The Journal of Biological Chemistry 273(19):11695-11700,1998
‘æ5‰ñ ‘åãŽs—§‘åŠwˆãŠw•”®Œ`ŠO‰È Š£@Œ’‘¾˜Y Local Application of Basic Fibroblast Growth Factor Minipellet Induces the Healing of Segmental Bony Defects in Rabbits. Calcified Tissue International 63(6):490-495,1998
‘æ6‰ñ –¼ŒÃ‰®‘åŠwˆãŠw•”®Œ`ŠO‰È ¼“c@‰ÀO Antisense inhibition of Hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention nad matrix assembly. The Journal of Biological Chemistry 274(31):21893-21899,1999
‘æ6‰ñ ‰ªŽR‘åŠwŽ•Šw•”Œûo¶‰»Šw ’†¼@“O Effects of CTGF/Hcs24, a Product of a hypertrophic Chondrocyte-Specific Gene on the Proliferation and Differentiation of Chondrocytes in Culture. Endocrinology 141:264-273,2000
‘æ6‰ñ L“‡‘åŠwŽ•Šw•”Ž•‰È•â’ÔŠw@@@@@@‘æ“ñuÀ –q•½@´’´ Enhancement of Cell Adhesion and Spreading by a Cartilage-specific Noncollagenous Protein, Cartilage Matrix Protein(CMP/Matrilin-1), via Integrin ƒ¿1 ƒÀ1 The Journal of Biological Chemistry 274(16):11417-11423,1999
‘æ6‰ñ “Œ‹žŽœŒb‰ïˆã‰È‘åŠw®Œ`ŠO‰È ‹g“c@‰q In Vitro Synthesis of Hyaluronan by a Single Protein Derived from Mouse HAS1 Gene and Characterization of Amino Acid Residues Essential for the Activity The Journal of Biological Chemistry 275(1):497-506,2000
‘æ6‰ñ ‹ãB‘åŠwˆãŠw•”®Œ`ŠO‰È “c’‡@˜aG Azinc-Finger Transcription Factor, CRYBP1, Is a Negative Regulator of the Chondrocyte-Specific Enhancer of the ƒ¿1(‡U)Collagen Gene. Molecular and Cellular Biology 20(12):4428-4435,2000
‘æ7‰ñ L“‡‘åŠwŽ•Šw•”ŒûoŒ’N”­ˆçŠw@@@iŽ•‰È‹¸³Šwj –{“c@N•¶A‘å–ì@–Î The effects of high magnitude cyclic tensile load on cartilage matrix metabolism in cultured chondrocytes European Journal of Cell Biology 79:601-609,2000
‘æ7‰ñ University of Texas Health Science Center •y“c@‰vL Nitric Oxide Regulates Mitochondrial Respiration and Functions of Articular Chondrocytes Arthritis and Rheumatism 44(1):96-104,2001
‘æ7‰ñ ‰¡•lŽs—§‘åŠwˆãŠw•”®Œ`ŠO‰È ã™@¹Í Inflammatory Properties of IgG Modified by Oxygen Radicals and Peroxynitrite The Journal of Immunology 165:6532-6537,2000
‘æ7‰ñ Ž­Ž™“‡‘åŠwˆãŠw•”®Œ`ŠO‰È ‘O“c@^Œá Functional impact of human collagen ƒ¿2(X1)gene polymorphism in pathpgenesis of ossification of the posterior longitudinal ligament of the spine The Journal of Bone and Mineral Research 16(5):948-957,2001
‘æ8‰ñ “Œ‹ž‘åŠwˆãŠw•”®Œ`ŠO‰È ‰ºÔ@—² Regulation of Osteoblast, Chondrocyte, and Osteoclast Functions by Fibroblast Growth Factor(FGF)-18 in Comparison with FGF-2 and FGF-10 The Journal of Biological Chemistry 277:7493-7500,2002
‘æ8‰ñ ‹ž“s‘åŠwˆãŠw•”®Œ`ŠO‰È ˆÉ“¡@é Molecular Cloning and Biological Activity of a Novel Lysyl Oxidase-velated Gane Expressed in Cartilage The Journal of Biological Chemistry 276(26):24023-24029,2001
‘æ8‰ñ ŒQ”n‘åŠwˆãŠw•”®Œ`ŠO‰È _ŒË@Ž–¾ Stimulation of matrix metalloprotease 3 relcase from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4. Arthritis and Rheumatism 46:130-137,2002
‘æ9‰ñ ‹ž“s‘åŠwˆãŠw•”®Œ`ŠO‰È ˆÀ“c@‹` Involvement of CD44 in Induction of Matrix Metalloproteinases by a Carbozyl-terminal Heparin-binding Fragment of Fibronection in Human Articular Cartilage in Culture Arthritis and Rheumatism 48:1271-1280,2003
‘æ9‰ñ “¿“‡‘åŠwˆãŠw•”®Œ`ŠO‰È ¼ˆä@Dl COLAAA2 Collagen Gene Transcription Is Differentially Regulated by EWS/ERG Sarcoma Fusion Protein and Wild-type ERG The Journal of Biological Chemistry 278:11369-11375,2003
‘æ9‰ñ ‹ãB‘åŠwˆãŠw•”®Œ`ŠO‰È ‰ªè@Œ« CCAAT/Enhancer-binding Proteins ƒÀ and ƒÂ Mediate the Repression of Gene Transcription of Cartilae-derived Retinoic Acid-sensitive Protein Induced by Interleukin-1ƒÀ The Journal of Biological Chemistry 277(35):31526-31533,2002
‘æ9‰ñ L“‡‘åŠwŽ•Šw•”Œûo¶‰»Šw Ketut Suardita Effects of overexpression of membrane-boud transferrin-like protein(MTf) on Chondogenic Differentiation in Vitro. The Journal of Biological Chemistry 277:48579-48586,2002
‘æ9‰ñ Œcœä‹`m‘åŠwˆãŠw•”®Œ`ŠO‰È ‰|–{@G”V Vascular Endothelial Growth Factor Isoforms and Their Receptors Are Expressed in Human Osteoarthritic Cartilage. American Journal of Pathology 162(1):171-181,2003
‘æ10‰ñ ‡“V“°‘åŠwˆãŠw•”®Œ`ŠO‰È £ŒË@G–¾ Distinct roles of Smad pathways and p38pathways in cartilage-specific gene expression in synovial fibroblasts The Journal of Clinical Investigation 113(5):718-726,2004
‘æ10‰ñ ˆ¤’mˆã‰È‘åŠw•ªŽqˆã‰ÈŠwŒ¤‹†Š ¼–{@˜a Distinct Interaction of Versican/PG-M with Hyaluronan and Link Protein. The Journal of Biological Chemistry 278(42):41205-41212,2003
‘æ10‰ñ Z—F»–òiŠ”jŒ¤‹†–{•”@ @@ @ ‘n–ò‘æ“ñŒ¤‹†Š ‹´–{@ŠwŽ¢ Matrix Metalloproteimases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165 The Journal of Biological Chemistry 277(39):36288-36295,2002
‘æ10‰ñ ‘åãŽs—§‘åŠwˆãŠw•”®Œ`ŠO‰È ‹´–{@—S‰î Mutation(D472Y) in the Type 3 Repeat Domain of Catilage Oligomeric Matrix Protein Affects Its Early Vesicle Trafficking in Endoplasmic Reticulum and Induces Apoptosis American Journal of Pathology 163(1):101-110,2003
‘æ10‰ñ “Œ‹ž‘åŠwˆãŠw•”®Œ`ŠO‰È ˜’ˁ@—T Cystain 10, a Novel Chondrocyte-specific Protein, May Promote the Last Steps of the Chondrocyte Differentiation Pathway The Journal of Biological Chemistry 278(48):48259-48266,2003
‘æ11‰ñ ŠÖ¼˜JÐ•a‰@®Œ`ŠO‰È –x–؁@[ Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia The Journal of Cell Biology 165(3):433-445,2004
‘æ11‰ñ ‹ãB‘åŠwˆãŠw•”®Œ`ŠO‰È â–{@º•v Chondrocyte-specific knockout of the G Protein Gs leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation. The Journal of Bone and Mineral 20(4):663-671 (2005)
‘æ11‰ñ “Œ‹ž‘åŠwˆãŠw•”®Œ`ŠO‰È ’}“c@”Ž—² Cyclic GMP-dependent protein kinase ‡U is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes GENES & DEVELOPMENT 18:2418-2429,2004
‘æ12‰ñ “Œ‹žˆã‰ÈŽ•‰È‘åŠw®Œ`ŠO‰È âŒû@—S•ã Superiority of synovium as cell source: Comparison of human stem cells derived from various mesenchymal tissues Arthritis and Rheumatism 52(8):2521-2529,2005
‘æ12‰ñ Šò•Œ‘åŠwˆãŠw•”®Œ`ŠO‰È _’J@éL Versican/PG-M Regulates Chondrogenesis as an Extracellular Matrix Molecule Crucial for Mesenchymal Condensation The Journal of Biological Chemistry 281(4):2390-2400,2006
‘æ12‰ñ ‹ž“s‘åŠwˆãŠw•”®Œ`ŠO‰È ‹g•x@Œ[”V A role for fungal ƒÀ-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice Journal of Experimental Medicine 201(6):949-960,2005
‘æ12‰ñ ‰ºŠÖŽs—§’†‰›•a‰@®Œ`ŠO‰È ¡‘º@ŽõG Transcriptional Co-activators CREB-binding Protein/p300 Increase Chondrocyte Cd-rap Gene Expression by Multiple Mechanisms CCAAT/Enhancer-binding Protein The Journal of Biological Chemistry 280(17):16625-16634,2005
‘æ12‰ñ ‹ž“s•{—§ˆã‰È‘åŠw®Œ`ŠO‰È ˆäã@“Ö•v The Therapeutic Effects of Basic Fibroblast Growth Factor Contained in Gelatin Hydrogel Microspheres on Experimental Osteoarthritis in the Rabbit Knee Arthritis and Rheumatism 54(1):264-270,2006
‘æ13‰ñ “Œ‹žˆã‰ÈŽ•‰È‘åŠw®Œ`ŠO‰È âˆä@Œ°ˆê˜Y Chondroitin Sulfate N-Acetylgalactosaminyltransferase-1 Plays a Critical Role in Chondroitin Sulfate Synthesis in Cartilage The Journal of Biological Chemistry 282(6):4152-4161,2007
‘æ13‰ñ ‹ž“s‘åŠwˆãŠw•”®Œ`ŠO‰È HŽR@Ž¡•F Osteo-chondroprogenitor cells are derived from SOX9 expressing precursors PNAS 102(41):14665-146710,2005
‘æ13‰ñ ‰ªŽR‘åŠwˆãŠw•”®Œ`ŠO‰È ŒÃ¼@‹B”V SOX9 and p300 cooperatively regulate chromatin-mediated transcription The Journal of Biological Chemistry 280(42):35203-35208,2005
‘æ13‰ñ “Œ‹ž‘åŠwˆãŠw•”®Œ`ŠO‰È Ö“¡@‘ô S100A1 and S100B, transcriptional targets of SOX trio, inhibit terminal differentiation of chondrocytes EMBO Reports 8(5):504-509,2007
‘æ13‰ñ ‘åã‘åŠwˆãŠw•”®Œ`ŠO‰È •½”ö@áÁ Oxygen Tension Regulates Chondrocyte Differentiation and Function during Endochondral Ossification The Journal of Biological Chemistry 281(41):31079-31092,2006
‘æ14‰ñ MB‘åŠwˆãŠw•”®Œ`ŠO‰È ’†‘º@K’j The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling The Journal of Clinical Investigation 117(10):3075-3086,2007
‘æ14‰ñ “Œ‹ž‘åŠwˆãŠw•”®Œ`ŠO‰È ŽR“c@‚Žk Carminerin contributes to chondrocyte calcification during endochondral ossification Nature Medicine 12(6):665-670,2006
‘æ14‰ñ Œcœä‹`m‘åŠwˆãŠw•”®Œ`ŠO‰È X“c@W‘¢A@‹{–{@Œ’Žj Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification The Journal of Experimental Medicine 204:1613-1623,2007
‘æ14‰ñ ‰ªŽR‘åŠw‘åŠw‰@@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Œûo¶‰»E•ªŽqŽ•‰ÈŠw ]Œû@Œ†“¿ Novel Transcription Factor-Like Function of Human Matrix Metalloproteinase 3 Regulating the CTGF/CCN2 Gene Molecular & Cellular Biology 28(7):2391-2413,2008
‘æ14‰ñ Œcœä‹`m‘åŠwˆãŠw•”@®Œ`ŠO‰È ŽO”ö@‘¾ A Functional Polymorphism in COL11A1, Which Encodes the ƒ¿1 Chain of Type X1 Collagen, Is Associated with Susceptibility to Lumbar Disc Herniation The American Journal of Human Genetics 81:1271-1277,2007
‘æ15‰ñ ‰¡•l˜JÐ•a‰@®Œ`ŠO‰È ìè@—m‰î Phosphorylation of GSK-3ƒÀ by cGMP-dependent protein kinase ? promotes hypertrophic differentiation of murine chondrocytes The Journal of Clinical Investigation 118:2506-2515,2008
‘æ15‰ñ ‹ãB‘åŠwˆãŠw•”®Œ`ŠO‰È ‰ª“c@ˆ¤Žq ADAM-12(Meltrin ƒ¿) Is Involved in Chondrocyte Proliferation via Clearvage of Insulin-like Growth Factor Binding Protein 5 in Osteoarthritic Cartilage ARTHRITIS & RHEUMATISM 58(3):778-789,March 2008
‘æ15‰ñ Œcœä‹`m‘åŠwˆãŠw•”®Œ`ŠO‰È œA£@—Tˆê˜Y A Functional Polymorphism in THBS2 that Affects Alternative Splicing and MMP Binding Is Associated with Lumbar-Disc Herniation The American Journal of Human Genetics 82:1122-1129,May 2008
‘æ15‰ñ ‘åã‘åŠwˆãŠw•”®Œ`ŠO‰È Šâˆä@‹M’j Smad7 Inhibits Chondrocyte Differentiation at Multiple Steps during Endochondral Bone Formation and Down-regulates p38 MAPK Pathways The Journal of Biological Chemistry 283(40):27154-27164,Oct. 2008
‘æ15‰ñ “Œ‹ž‘åŠw‘åŠw‰@ˆãŠwŒnŒ¤‹†‰È®Œ`ŠO‰È •½“c@^ C/EBPƒÀ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2 PLoS ONE 4(2):e4543,February 2009
‘æ15‰ñ Ž­Ž™“‡‘åŠw‘åŠw‰@‰^“®‹@”\C•œŠwuÀ®Œ`ŠO‰ÈŠw ’JŒû@¸ Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis The National Academy of Sciences of the USA 106(4):1181-1186,January 2009
‘æ16‰ñ Harvard Medical School, Department of Genetics ›@“N“¿ Screening of Chondrogenic Factors With a Real-time Fluorescence-Monitoring Cell Line ATDC5-C2ER Identification of Sorting Nexin 19 as a Novel Factor ARTHRITIS & RHEUMATISM 60(11): 3314-3323,November 2009
‘æ16‰ñ ‹ž“sŽs—§•a‰@®Œ`ŠO‰È –kÜ@r”V Stromal Cell-Derived Factor 1/CXCR4 Signaling Is Critical for the Recruitment of Mesenchymal Stem Cells to the Fracture Site During Skeletal Repair in a Mouse Model ARTHRITIS & RHEUMATISM 60(3): 813-823,March 2009
‘æ16‰ñ ‹ãB‘åŠwˆãŠwŒ¤‹†‰@®Œ`ŠO‰ÈŠw —Ñ“c@Œõ³ CCAAT/Enhancer Binding Protein ƒÀMediates Expression of Matrix Metalloproteinase 13 in Human Articular Chondrocytes in Inflammatory Arthritis ARTHRITIS & RHEUMATISM 60(3): 708-716,March 2009
‘æ16‰ñ “Œ‹ž‘åŠwˆãŠw•”®Œ`ŠO‰È [ˆä@Œú Akt1 in Murine Chondrocytes Controls Cartilage Calcification Durting Endochondral Ossification Under Physiologic and Pathologic Conditions ARTHRITIS & RHEUMATISM 62(3): 826-836,March 2010
‘æ16‰ñ –kŠC“¹‘åŠw•a‰@®Œ`ŠO‰È ¼ˆä@—Yˆê˜Y Accelerated Development of Aging-Associated and Instability-Induced Osteoarthritis in Osteopontin-Deficient Mice ARTHRITIS & RHEUMATISM 60(8): 2362-2371,August 2009
‘æ17‰ñ ‘—§¬ˆçˆã—ÃZƒ“ƒ^[Œ¤‹†Š ƒVƒXƒeƒ€”­¶EˆãŠwŒ¤‹†•” ˆÉ“¡@‹`W The Mohawk homeobox gene is a critical regulator of tendon differentiation Proc Natl Acad Sci U S A. 107(23):10538-42,June 2010
‘æ17‰ñ ‘åãˆã‰È‘åŠw®Œ`ŠO‰È ‘å’΁@Žü•½ Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Proc Natl Acad Sci U S A. 107(22):10202-7,June 2010
‘æ17‰ñ Œcœä‹`m‘åŠwˆãŠw•”•a—Šw‹³Žº –Ø‘º@“¿G RECK Is Up-Regulated and Involved in Chondrocyte Cloning in Human Osteoarthritic Cartilage American Journal of Pathology 176(6):2858-67,June 2010
‘æ17‰ñ “ŒŠC‘åŠwˆãŠw•”•‘®•a‰@®Œ`ŠO‰È žwŽR@–¾•F Enhancement of Intervertebral Disc Cell Senescence by WNT/ƒÀ-Catenin Signaling -Induced Matrix Metalloproteinase Expression Arthritis & Rheumatism 62(10):3036-47,October 2010
‘æ17‰ñ ‹ž“s‘åŠwˆãŠw•”®Œ`ŠO‰È ŽR–{@_Ži Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25 Nature Communications 2:Article No.251,March 2011