医療薬学研究室紹介

研究業績

◆日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2015 宮崎 雅之主任の成果

平成27年度

◆平成25年度日本薬学会東海支部 永井 拓 准教授の成果

平成25年度

◆第1回日本神経精神薬理学会学術奨励賞 永井 拓 准教授の成果

平成24年度

◆第132回日本薬学会 水野 智博 大学院生の成果

平成23年度

◆第2回アジア神経精神薬理学会(AsCNP)ソウル大会 尹 錫在 大学院生の成果

平成23年度

◆第3回NAGOYAグローバルリトリート 日比 陽子 特任助教の成果

平成22年度

◆化学物質リスク研究事業(厚生労働科学研究費補助金、主任研究者:鍋島俊隆)の成果

平成21年度
平成20年度

◆原著(欧文)

2017年
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  1. Itoh N, Nagai T, Watanabe T, Taki K, Nabeshima T, Kaibuchi K, Yamada K.: Valocin-containing protein (VCP) is a novel IQ motif-containing GTPase activating protein 1 (IQGAP1) interacting protein. Biochem. Biophy. Res. Commun. 493:1384-1389, 2017.
  2. Tran HQ, Chung YH, Shin EJ, Tran T-Y, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Kim HC: Mk-801, but not naloxone, atteneuates high-dose dextropethorpahn-induced convulsive behavior: Possble involvement of the GluN2B receptor. Tox. App. Pharmacol. 334:158-166, 2017.
  3. Tran V, Shin E-J, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC: Protein Kinase Cδ Gene Depletion Protects Against Methamphetamine-Induced Impairments in Recognition Memory and ERK1/2 Signaling via Upregulation of Glutathione Peroxidase-1 Gene. Mol Neurobiol., doi:10.1007/s12035-017-0638-8, 2017.
  4. Mouri A, Noda Y, Niwa M, Matsumoto Y, Mamiya T, Nitta A, Yamada K, Furukawa S, Iwamura T, Nabeshima T: The involvement of brain-derived neurotrophic factor in 3,4-methylenedioxymethamphetamine-induced place preference and behavioral sensitization. Behav Brain Res., 329:157-165, 2017.
  5. Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H: Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice. Neuroscience 351:15-23, 2017.
  6. Kubo K, Deguchi K, Nagai T, Ito Y, Endo T, Benner S, Shan W, Kitazawa A, Aramaki M, Ishii K, Kakeyama M, Tohyama C, Tanaka K, Takashima S, Nakayama M, Itoh M, Antalffy M, Armstrong D D, Yamada K, Inoue K, Nakajima K: Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. JCI Insight. 2017 May 18;2(10). pii: 88609. doi: 10.1172/jci.insight.88609.
2016年
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  1. Tran V, Shin E-J, Jeong JH, Lee JW, Lee Y, Jang CG, Nah SY, Lei XG, Toriumi K, Yamada K, Nabeshima T, Kim HC. Protective potential of the glutathione peroxidase-1 gene in abnormal behaviors induced by phencyclidine in mice. Mol Neurobiol., DOI 10.1007/s12035-016-0239-y, 2016.
  2. Tran V, Shin EJ, Ko SK, Nam Y, Chung YH, Jeong JH, Jang CG, Nah SY, Yamada K, Nabeshima T, Byun JK, Kim HC: Mountain-cultivated ginseng attenuates phencyclidine-induced abnormal behaviors in mice by positive modulation of glutathione in the prefrontal cortex of mice. J. Med. Food, 19:1-9, 2016.
  3. Tran V, Chung YH, Shin E-J, Kim WK, Lee JC, Jeong JH, Wie MB, Jang CG, Yamada K, Nabeshima T, Kim HC. High-dose dextromethorphan produces myelinod bodies in the hippocampus of rats. J. Pharmacol. Sci. 132:166-170, 2016.
  4. Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K.: Phospho-proteomics of the dopamine pathway enables discovery of Rap1 activation as a reward signal in vivo. Neuron 89: 550-565, 2016.
  5. Aoyama Y, Toriumi K, Mouri A, Hattori T, Ueda E, Shimato A, Sakakibara N, Soh Y, Mamiya T, Nagai T, Kim HC, Hiramatsu M, Nabeshima T, Yamada K: Prenatal nicotine exposure impairs the proliferation of neuronal progenitors, leading to fewer glutamatergic neurons in the medial prefrontal cortex. Neuropsychopharmacology 41: 578-589, 2016.
  6. Yoshimi A, Noda Y, Aleksic B, Senzaki K, Ohashi M, Yamada S, Yamada K and Ozaki N: The survey of antipsychotic polypharmacy in outpatients at Nagoya University Hospital. Clin. Neuropsychopharmacol. Ther., in press.
2015年
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  1. Sakaguchi H, MuramatsuH, Makishima H, Xu Y, Hibi Y, Wang X, Narita A, Okuno Y, Yoshida K, Shiraishi Y, Doisaki S, Yoshida N, Hama A, Takahashi Y, Yamada K, Miyano S, Ogawa S, Maciejewski JP, Kojima S.: Aberrant DNA methylation is associated with a poor outcome in juvenile myelomonocytic leukemia. PLOS ONE, 2015 Dec 31;10(12):e0145394. doi: 10.1371/journal.pone.0145394.
  2. Hori K, Nagai T, Shan W, Sakamoto A, Abe M, Yamazaki M, Sakimura K, Yamada K, Hoshino M: Heterozygous disruption of Autism susceptibility candidate 2 causes impaired emotional control and cognitive memory. PLOS ONE 10(12): e0145979.doi:10.1371/journal.pone.014579, 2015
  3. Mita T, Furukawa-Hibi Y, Takeuchi H, Hattori H, Yamada K, Hibi H, Ueda M, Yamamoto A: Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer's disease. Behav Brain Res. 293:189-197, 2015.
  4. Furukawa-Hibi Y, Yun J, Nagai T, Yamada K: Stress increases DNA methylation of the neuronal PAS domain 4 (Npas4) gene. Neuroreport 26:827-832, 2015.
  5. Mizoguchi H, Katahira K, Inutsuka A, Fukumoto K, Wang T, Nagai T, Sato J, Sawada M, Ohira H, Yamanaka A, Yamada K: Insular neural system controls decision-making in healthy and methamphetamine-treated rats. Proc. Natl. Acad. Sci. USA., 112:E3930-3939, 2015.
  6. Udagawa T, Fujioka Y, Tanaka M, Honda D, Yokoi S, Riku Y, Ibi D, Nagai T, Yamada K, Watanabe H, Katsuno M, Inada T, Ohno K, Sokabe M, Okado H, Ishigaki S, Sobue G: FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization. Nat. Commun. 6:7098 doi: 10.1038/ncomms8098, 2015.
  7. Ishii K, Nagai T, Hirota Y, Noda M, Nabeshima T, Yamada K, Kubo K, Nakajima K.: Reelin has a preventive effect on phencyclidine-induced cognitive and sensory-motor gating deficits. Neurosci. Res. 96:30-36, 2015.
  8. Nakajima A, Aoyama Y, Shin, EJ, Nam Y, Kim HC, Nagai T, Yokosuka A, Mimaki Y, Yokoi, T, Ohizumi Y, Yamada K: Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Ab levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD). Behav. Brain Res. 289: 69-77, 2015.
  9. Hida H, Mouri A, Mori K, Matsumoto Y, Seki T, Taniguchi M, Yamada K, Iwamoto K, Ozaki N, Nabeshima T, Noda Y: The complex mechanism of blonanserin action involving D3-5-HT2A and D1-NMDA receptors in the mPFC. Neuropsychopharmacology 40:601-613, 2015.
2014年
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  1. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, and Nabeshima T.: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int. J. Neuropsychopharmacol. 17:443-453, 2014.
  2. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N,Yamada K, Nabeshima T and Noda Y: Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behav. Brain Res., 258:34-42, 2014.
  3. Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K and Nabeshima T: Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. Int. J. Neuropsychopharmacol. In press.
  4. Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F and Toyokuni S: Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage by in utero ischemia-reperfusion. Free Radic. Biol. Med., in press.
  5. Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, and Yamada K: Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Brain Behav Immun., in press.
  6. Nakajima N, Ohizumi Y, Yamada K: Anti-dementia activity of nobiletin, a citrus flavonoid. Clin. Psychopharmacol. Neurosci., in press.
  7. Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M.: Cytoskeletal Regulation by AUTS2 in Neuronal Migration and Neuritogenesis. Cell Rep. 9:2166-2179, 2014.
  8. Nakajima A, Ibi D, Nagai T, Yamada S, Nabeshima T, Yamada K: Induction of interferone-induced transmembrane protein 3 gene expression by lipopolysaccharide in astrocytes. Eur. J. Pharmacol., 745:166-175, 2014.
  9. Nakai T, Nagai T, Tanaka M, Itoh N, Asai N, Enomoto A, Asai M, Yamada S, Saifullah MAB, Sokabe M, Takahashi M, Yamada K: Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. J. Neurosci., 34:14995-15008, 2014.
  10. Maeda O, Ando T, Ohmiya N, Ishiguro K, Watanabe O, Miyahara R, Hibi Y, Nagai T, Yamada Yoshihara S, Takahashi H, Nishimura N, Kinoshita M, Asahina R, Kitsuki M, Tatsumi K, Hibi Y, Hirai H, Nagai T, Yamada K, Tsuboi A: Npas4 regulates the expression of Mdm2 that ubiquitinates Dcx to remodel dendritic spines in olfactory bulb interneurons after sensory experience. Cell Rep, 8:1-15, 2014.
  11. Nakai T, Nagai T, Wang R, Yamada S, Kuroda K, Kaibuchi K, Yamada K: Alterations of GABAergic and dopaminergic system in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Neurochem. Int., 74:74-83, 2014.
  12. Yamada S, Nagai T, Nakai T, Ibi D, Nakajima A, and Yamada K: Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes. Brain Behav Immun., 38:272-282, 2014.
  13. Aoyama Y, Mouri A, Toriumi K, Koseki T, Narusawa S, Ikawa N, Mamiya T, Nagai T, Yamada K, Nabeshima T: Clozapine ameliorates epigenetic and behavioral abnormalities induced by phencyclidine through activation of dopamine D1 receptor. Int. J. Neuropsychopharmacol., 17:723-737, 2014.
  14. Hida H, Mouri A, Ando Y, Mori K, Mamiya T, Iwamoto K, Ozaki N, Yamada K, Nabeshima T, Noda Y: Combination of neonatal Polyl:C and adolescent phencyclidine treatments is required to induce behavioral abnormalities with overexpression of GLAST in adult mice. Behav. Brain Res., 258:34-42, 2014.
  15. Toriumi K, Kondo M, Nagai T, Hashimoto R, Ohi K, Song Z, Tanaka J, Mouri A, Koseki T, Yamamori H, Furukawa-Hibi Y, Mamiya T, Fukushima T, Takeda M, Nitta A, Yamada K, Nabeshima T.: Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence. Int. J. Neuropsychopharmacol., 17:443-453, 2014.
2013年
  1. Mouri A, Nagai T, Ibi D and Yamada K: Animal models of schizophrenia for molecular and pharmacological intervention and potential candidate molecules. Neurobiol. Dis., 53:61-74, 2013.
  2. Mizoguchi H and Yamada K: Roles of matrix metalloproteinases and their targets in epileptogenesis and seizures. Clin. Psychopharmacol. Neurosci., 11:45-52, 2013
  3. Miyazaki M, Noda Y, Mouri A, Kobayashi K, Mishina M, Nabeshima N, Yamada K: Role of convergent activation of glutamatergic and dopaminergic systems in the nucleus accumbens in the development of methamphetamine psychosis and dependence. Int. J. Neuropsychopharmacol., 16(6):1341-50, 2013.
  4. Yun J, Nagai T, Furukawa-Hibi Y, Kuroda K, Kaibuchi K and Yamada K: Neuronal Per Arnt Sim (PAS) domain protein 4 (Npas4) regulates neurite outgrowth and phosphorylation of synapsin I. J. Biol. Chem., 288: 2655-2664, 2013.
  5. Ibi D, Nagai T, Nakajima A, Mizoguchi H, Kawase T, Tsuboi D, Kano S, Sato Y, Hayakawa M, Lange UC, Adams DJ, Surani MA, Satoh T, Sawa A, Kaibuchi K, Nabeshima T and Yamada K: Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia 61: 679-693, 2013.
  6. Alkam,T, Kim HC, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K and Nabeshima T: Evaluation of emotional behaviors in young offspring of C57BL/6J mice after gestational and/or perinatal exposure to nicotine in six different time-windows. Behav. Brain Res., 239:80-89, 2013.
  7. Zhang L, Nagai T, Yamada K, Ibi D, Ichihara S, Suburamanian K, HuangZ, Mohideen SS, Naito H and Ichihara G.: Effects of sub-acute and sub-chronic inhalation of 1-bromopropane on neurogenesis in adult rats. Toxicology, 304:76-82, 2013.
  8. Yan Y, Miyamoto Y, Nitta A, Muramatsu S, Ozawa K, Yamada K and Nabeshima T: Intrastriatal gene delivery of GDNF persistently attenuates methamphetamine self-administration and relapse in mice. Int. J. Neuropsychopharmacol., 16:1559-1567, 2013.
  9. Nakajima A, Aoyama Y, Nguyen TTL, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y and Yamada K: Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behav. Rain Res., 250:351-360, 2013.
  10. Alkam T, Kim HC, Mamiya T, Yamada K, Hiramatsu M and Nabeshima T: Evaluation of cognitive behaviors in young offspring of C57BL/6J mice after gestational nicotine exposure during different time-windows. Psychopharmacology, 230:451-463, 2013.
  11. Toriumi K, Miki I, Kondo M, Mouri A, Koseki T, Ibi D, Hurukawa-Hibi Y, Nagai T, Mamiya T, Nitta A, Yamada K and Nabeshima T: SHATI/NAT8L regulates neurite outgrowth via microtubule stabilization. J. Neurosci. Res., 91:1525-1532, 2013.
2012年
  1. Tran HY, Shin EJ, Saito K, Nguyen XK, Chung YH, Jeong JH, Bach JH, Park DH, Yamada K, Nabeshima T, Yoneda Y, Kim HC.: Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo. Free Radic.Biol. Med., 52:1159-1174, 2012.
  2. Takuma K, Mizoguchi H, Funatsu Y, Hoshina Y, Himeno Y, Fukuzaki E, Kitahara Y, Arai S, Ibi D, Kamei H, Matsuda T, Koike K, Inoue M, Nagai T and Yamada K: Combination of chronic stress and ovariectomy causes conditioned fear memory deficits and hippocampal cholinergic neuronal loss in mice. Neuroscience, 207:261-273, 2012.
  3. Mouri A, Sasaki A, Watanabe K, Sogawa C, Kitayama S, Mamiya M, Miyamoto Y, Yamada K, Noda Y and Nabeshima T: MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation. J. Neurosci., 28:4562-4580, 2012.
  4. Yan Y, Nitta A, Koseki T, Yamada K, Nabeshima T: Dissociable role of tumor necrosis factor alpha gene deletion in methamphetamine self-administration and cue-induced relapsing behavior in mice. Psyhopharmacology 221: 427-436, 2012.
  5. Jin D, Muramatsu S, Shimizu N, Yokoyama S, Hirai K, Yamada K, Liu H-X, Higashida C, Hashii M, Higashida A, Asano M, Ohkuma S and Higashida H: Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice. Neurochem. Int., 61:907-912, 2012.
  6. Nakamoto K, Kawasaki S, Kobori T, Fujita-Hamabe W, Mizoguchi H, Yamada K, Nabeshima T, Tokuyama S: Involvement of matrix metalloproteinase-9 in the development of morphine tolerance. Eur. J. Pharmacol., 683:86-92, 2012.
  7. Nakajima A, Kinugasa Y, Torii J, Hishinuma T, Tomioka Y, Yamada K , Yamakuni T: Repeated treatment with nicotine induces phosphorylation of NMDA receptor NR2B subunit in the brain regions involved in behavioral sensitization. Neurosci. Lett., 524:133-138, 2012.
  8. Takuma K, Mizoguchi H,Funatsu Y, Kitahara Y, Ibi D, Kamei H, Matsuda T, KoikeK, Inoue M, Nagai T, Yamada K: Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice. J. Pharmacol. Sci., 120:89-97, 2012.
  9. Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Toriumi K, Furukawa S, Nabeshima T and Yamada K: Absence of SHATI/Nat81 reduces social interaction in mice. Neurosci. Lett., 526:79-84, 2012.
  10. Nagai T, Yu J, Kitahara Y, Nabeshima T and Yamada K: D-serine ameliorates neonatal polyI:C treatment-induced emotional and cognitive impairments in adult mice. J. Pharmacol. Sci., 120:213-227, 2012.
  11. Furukawa-Hibi Y, Yun J, Nagai T and Yamada K.: Transcriptional suppression of the neuronal PAS domain 4 (Npas4) gene by stress via the binding of agonist-bound glucocorticoid receptor to its promoter. J. Neurochem., 123:866-875, 2012.
2011年
  1. Mizoguchi H, Ibi D, Takase F, Nagai T, Kamei H, Toth E, Sato J, Takuma K and Yamada K: Nicotine ameliorates impairment of working memory in methamphetamine-treated rats. Behav. Brain Res. 220:159-163, 2011.
  2. Alkam T, Hiramatsu M, Mamiya T, Aoyama Y, Nitta A, Yamada K, Kim HC and Nabeshima T: Evaluation of object-based attention in mice. Behav. Brain Res. 220:185-193, 2011.
  3. Shin EJ, Kim JM, Nguyen XKT, Nguyen TTL, Lee SY, Jung JH, Kim MJ, Whang WK, Yamada K, Nabeshima T and Kim HC: Effect of Gastrodia Elata Bl on phencyclidine-induced schizophrenia-like psychosis in mice. Curr. Neuropharmacol. 9:247-250, 2011.
  4. Wakasaya Y, Kawarabayashi T, Watanabe M, Yamamoto-Watanabe Y, Takamura A, Kurata T, Murakami T, Abe K, Yamada K, Wakabayashi K, Sasaki A, Westaway D, Hyslop PG, Matsubara E, Shoji M: Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy. J. Neurosci. Res. 89:576-584, 2011.
  5. Furukawa-Hibi Y, Nitta A, Ikeda T, Morishita K, Liu W, Ibi D, Alkam T, Nabeshima T and Yamada K: The hydrophobic dipeptide Leu-Ile inhibits immobility induced by repeated forced swimming via the induction of BDNF. Behav Brain Res., 220: 271-280, 2011.
  6. Shichi K, Fujita-Hamabe W, Harada S, Mizoguchi H, Yamada K, Nabeshima T and Tokuyama S: Involvement of matrix metalloproteinase-mediated proteolysis of neuronal cell adhesion molecule in the development of cerebral ischemic neuronal damage. J. Pharmacol. Exp. Ther., 338:701-710, 2011.
  7. Furukawa-Hibi Y, Alkam T, Nitta A, Matsuyama A, Mizoguchi H, Suzuki K, Moussaoui S, Yu Q-S, Greig NH, Nagai T and Yamada K: Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-s peptide in mice. Behav Brain Res., 225:222-229, 2011.
  8. Nagai T, Kitahara Y, Ibi D, Nabeshima T, Sawa A and Yamada K: Effects of antipsychotics on the behavioral deficits in human dominant-negative DISC1 transgenic mice with neonatal polyI:C treatment. Behav. Brain Res., 225:305-310, 2011.
  9. Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, Itohara S, Takuma K, Sawada M, Sato J and Yamada K: Matrix metalloproteinase-9 contributes to kindlined seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. J Neurosci., 31:12963-12971, 2011.
  10. Kuroda K, Yamada S, Tanaka, Iizuka M, Yano H, Mori D, Tsuboi D, Nishioka T, Namba T, Iizuka Y, Kubota S, Nagai T, Ibi D, Wang R, Enomoto A, Isotani-Sakakibara M, Asai N, Kimura K, Kiyonari H, Abe T, Mizoguchi A, Sokabe M, Takahashi M, Yamada K and Kaibuchi K: Behavioral alterations associated with targeted disruption of exons 2 and 3 of the DISC1 gene in the mouse. Hum. Mol. Genet., 20, 4666-4683, 2011.
  11. Mizoguchi H. and Yamada K: Pharmacologic treatment with GABAB receptor agonist on methamphetamine-induced cognitive impairment in mice. Curr. Neuropharmacol., 9, 109-112, 2011.
  12. Yamada K: Translational research in neurodevelopmental disorders: Development of etiology-based animal models (Foreword). Biol. Pharm. Bull. 34, 1357, 2011.
  13. Nagai T, Ibi D and Yamada K: Animal model for schizophrenia that reflects gene-environment interactions. Biol. Pharm. Bull. 34, 1364-1368, 2011.
  14. Mizoguchi H, Yamada K and Nabeshima T: Matrix metalloproteinases contribute to neuronal dysfunction in animal models of drug dependence, Alzheimer’s disease, and epilepsy. Biochem. Res. Int., 2011.
2010年
  1. Ibi D, Nagai T, Koike H, Kitahara Y, Mizoguchi H, Niwa M, Jaaro-Peled H, Nitta A, Yoneda Y, Nabeshima T, Sawa A, and Yamada K: Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood. Behav. Brain Res., 206, 32-37, 2010.
  2. Nagai T, Kitahara Y, Shiraki A, Hikita T, Taya S, Kaibuchi K and Yamada K: Dysfunction of dopamine release in the prefrontal cortex of dysbindin deficient sandy mice: an in vivo microdialysis study. Neurosci. Lett., 470:134-138, 2010.
  3. Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, Zou LB, Nagai T, Yamada K, Ikejima T, Nabeshima T.: Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res., 207:387-393, 2010.
  4. Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, and Hattori K: Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Blood, 115:4302-4312, 2010.
  5. Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Doi H, Mizoguchi H, Nitta A, Yamada K, Banno H, Suzuki K, Tanaka F, and Sobue G: Disrupted TGF-beta signaling in spinal and bulbar muscular atrophy. J. Neurosci., 30:5702-5712, 2010.
  6. Alkam T, Nitta A, Furukawa-Hibi Y, Niwa M, Mizoguchi H, Yamada K, and Nabeshima T.: Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. Behav Brain Res., 210:184-90, 2010.
  7. Yu J, Nagai T, Ibi D, Kitahara Y, Nabeshima T and Yamada K.: Nicotine ameliorates emotional and cognitive impairments induced by neonatal polyI:C treatment in mice. The Open Behavioral Science Journal., 4: 9-18, 2010.
  8. Mizoguchi H, Ibi D, Takuma K, Toth E, Sato J, Itohara S, Nabeshima N and Yamada K.: Alterations of emotional and cognitive behaviors in matrix metalloproteinase-2 and -9-deficient mice. The Open Behavioral Science Journal., 4: 19-25, 2010.
  9. Yun J, Koike H, Ibi D, Toth E, Mizoguchi H, Nitta A, Yoneyama M, Ogita K, Yoneda Y, Nabeshima T, Nagai T and Yamada K: Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: a possible involvement of a brain specific transcription factor Npas4. J. Neurochem, 114:1840-1851, 2010.
  10. Shin EJ, Whang WK, Kim S, Bach JH, Kim JM, Nguyen XKT, Nguyen TTL, Jung BD, Yamada K, Nabeshima T and and Kim HC: Parshin C attenuate phencyclidine-induced schizophrenia-like psychosis in mice: involvement of 5-HT1A receptor. J. Pharmacol. Sci. 113:404-408, 2010.
  11. Furukawa-Hibi Y, Nitta A, Fukumitsu H, Somiya H, Furukawa S, Nabeshima T and Yamada K: Overexpression of piccolo C2A domain induces depression-like behavior in mice. Neuroreport 21:1177-1181, 2010.
  12. Noda Y, Mouri A, Ando Y, Waki Y, Yamada SN, Yoshimi A, Yamada K, Ozaki N, Wang D, Nabeshima T.: Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. Int J Neuropsychopharmacol. 13: 1343-1354, 2010.
2009年
  1. Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Kamei H, Kim H.C. and Yamada K: GABAB receptor agonist baclofen improve methamphetamine-induced cognitive deficit in mice. Eur. J. Pharmacol. 602, 101-104, 2009.
  2. Villard V, Espallergues J, Keller E, Alkam T, Nitta A, Yamada K, Nabeshima, T, Vamvakides A and Maurice T: Anti-amnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice. Neuropsychopharmacology,34, 1552-1566, 2009.
  3. Shin EJ, Chae JS, Park SJ, Kim SC, Koo KH, Yamada K, Nabeshima T and Kim HC: Growth hormone-releaser attenuates β-amyloid (1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF) -1 receptor in mice. J. Pharmacol. Sci. 109, 139-143, 2009.
  4. Gu B, Nakamichi N, Zhang WS, Nakamura Y, Kambe Y, Fukumori R, Takuma K, Yamada K, Takarada T, Taniura H, Yoneda Y: Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly. J. Neurosci. Res., 87, 2145-2156, 2009.
  5. Koike H, Ibi D, Mizoguchi H, Nagai T, Nitta A, Takuma K, Nabeshima T, Yoneda Y and Yamada K: Behavioral abnormality and pharmacologic response in social isolation-reared mice. Behav. Brain Res., 202, 114-121, 2009.
  6. Ibi D, Nagai T, Kitahara Y, Mizoguchi H, Koike H, Shiraki A, Takuma K, Kamei H, Noda N, Nitta A, Nabeshima T, Yoneda Y and Yamada K: Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood. Neurosci. Res., 64, 297-305, 2009.
  7. Kimura H, Yukitake H, Suzuki H, Tajima Y, Koyo Gomaibashi K, Morimoto S, Funabashi Y, Yamada K and Takizawa M.: A Chondroprotective Agent ITZ-1 Inhibits IL-1β-Induced MMP-13 Production and Suppresses NO-Induced Chondrocyte Death. J. Pharmacol. Sci., 110, 201-211, 2009.
  8. Shin EJ, Bing G, Chae JS, Kim TW, Bach JH, Park DH, Yamada K, Nabeshima T and Kim HC: Role of microsomal epoxide hydrolase in the methamphetamine-induced drug dependence in mice. J. Neurosci. Res., 87, 3679-3686, 2009.
  9. Jin CH, Shin EJ, Park JB, Jang CG, Li Z, Kim MS, Koo KH, Yoon HJ, Park SJ, Choi WC, Yamada K, Nabeshima T and Kim HC: Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment. J. Neurosci. Res., 87, 3658-3670, 2009.
  10. Shin EJ, Jang CG, Bing G, Park DH, Oh CH, Koo KH, Oh KW, Yamada K, Nabeshima T and Kim HC: Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice. Drug Alcohol Dependence, 104, 175-184, 2009.
  11. Mizoguchi H, Takuma K, Fukuzaki E, Ibi D, Someya E, Akazawa K, Alkam T, Tsunekawa H, Mouri A, Noda Y, Nabeshima T and Yamada K: Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice. J. Pharmacol. Exp. Ther., 331, 14-22, 2009.
  12. Otsuka N, Tsuritani K, Sakurai T, Kato K, Matoba R, Itoh J, Okuyama S, Yamada K and Yoneda Y. Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition. Brain Res., 1287, 136-145, 2009.
  13. Mizoguchi H, Arai S, Koike H, Ibi D, Kamei H, Nabeshima T, Kim HC, Takuma K and Yamada K: Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons. Psychopharmacology, 207:235-243, 2009.
  14. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K and Yan SD: RAGE-mdiated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction. Proc Natl Acad Sci USA, 106, 20021-20026, 2009.
2008年
  1. Mizoguchi H, Takuma K, Fukakusa A, Ito Y, Nakatani A, Ibi D, Kim HC and Yamada K: Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice. Psychopharmacology (Berl) 196, 233-241, 2008.
  2. Fukakusa A, Nagai T, Mizoguchi H, Otsuka N, Kimura H, Kamei H, Kim H-C, Nabeshima T, Takuma K and Yamada K: Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens. J. Neurochem. 105, 436-444, 2008.
  3. Ibi D, Takuma K, Koike H, Mizoguchi H, Tsuritani K, Kuwahara Y, Kamei H, Nagai T, Yoneda Y, Nabeshima T and Yamada K: Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice. J. Neurochem. 105, 921-932, 2008.
  4. Fukakusa A, Mizoguchi H, Koike H, Nabeshima T, Takuma K and Yamada K: Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity. J. Pharmacol. Sci. 106, 321-324, 2008.
  5. Fukuzaki E, Takuma K, Himeno Y, Yoshida S, Funatsu Y, Kitahara Y, Mizoguchi H, Ibi D, Koike K, Inoue M and Yamada K: Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits. Neurosci.Lett. 433, 141-145, 2008.
  6. Alkam T, Nitta A, Mizoguchi H, Saito K, Seshima M, Itoh A, Yamada K and Nabeshima T: Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice. Behav. Brain Res. 189, 100-106, 2008.
  7. Tamaki K, Yamada K, Nakamichi N, Taniura H and Yoneda Y: Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience. J. Neurochem. 105, 1642-1655, 2008.
  8. Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A: Production and functions of IL-17 in microglia. J. Neuroimmunol. 194, 54-61, 2008.
  9. Fukuzaki E, Takuma K, Funatsu Y, Himeno Y, Kitahara Y, Gu B, Mizoguchi H, Ibi D, Koike K, Inoue M, Yan SD and Yamada K: Ovariectomy increases neuronal amyloid ? binding alchohol dehydrogenease level in the mouse hippocampus. Neurochem. Int. 52, 1358-1364, 2008.
  10. Alkam T, Nitta A, Mizoguchi H, Itoh A, Murai R, Nagai T, Yamada K and Nabeshima T: The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid β in mice. J. Pharmacol. Exp. Ther. 327, 137-147, 2008.
  11. Yano K, Yamamura K, Osada T, Fukase F, Kiriyama N, Torimoto M, Yamada K, Kishi DT and Nabeshima T: Documenting the value of a pharmacist-managed anticoagulation classroom. J. Appl. Ther. Res. 6, 41-48, 2008.
  12. Arai S, Takuma K, Mizoguchi H, Ibi D, Nagai T, Takahashi K, Kamei H, Nabeshima T and Yamada K: Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen. Neuropsychopharmacology 33, 3164-3175, 2008.
  13. Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K and Nabeshima T: A novel molecule ‘shati’ increases dopamine uptake via the induction of tumor necrosis factor-α| in pheochromocytoma-12 cells. J. Neurochem. 107, 1697-1708, 2008.
  14. Kanazawa Y, Makino M, Morishima Y, Yamada K, Nabeshima T, Shirasaki Y: Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload. Neuroscience 154, 473-81, 2008.
  15. Yamada K and Kaneko S: Neuropsychotoxicity of abused drugs: Clinical and basic research and drug development: Preface [review]. J. Pharmacol. Sci. 106, 1, 2008.
  16. Mizoguchi H, Yamada K and Nabeshima T: Neuropsychotoxicity of Abused Drugs: Involvement of matrix metalloproteinase-2 and -9, and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents [review]. J. Pharmacol. Sci. 106, 9-14, 2008.
  17. Yamada K: Role for anti-addictive and pro-addictive factor in drug dependence [review]. Nagoya J. Med. Sci. 70, 67-72, 2008.
  18. Yamada K: Endogenous modulators for drug dependence [review]. Biol. Pharm. Bull. 31, 1635-1638, 2008.
  19. Nagai T, Nabeshima T and Yamada K: Basic and translational research on proteinase-activated receptors: Regulation of nicotine reward by the tissue plasminogen activator (tPA)-plasmin system via proteinase-activated receptor 1 [review]. J. Pharmacol. Sci. 108, 4048-414, 2008.
2007年
  1. Ito Y, Takuma K, Mizoguchi H, Nagai T and Yamada K: A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2. J. Pharmacol. Exp. Ther. 320, 819-827, 2007.
  2. Mizoguchi H, Yamada K, Niwa M, Mouri A, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T: Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice. J. Neurochem. 100, 1579-1588, 2007.
  3. Takahashi K, Nagai T, Kamei H, Maeda K, Matsuya T, Arai S, Mizoguchi H, Yoneda Y, Nabeshima T, Takuma K and Yamada K: Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice. Biol. Psychiatry 62, 148-157, 2007.
  4. Jin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M and Higashida H: CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446, 41-45, 2007.
  5. Yan Y, Yamada K, Nitta A and Nabeshima T: Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice. Behav. Brain Res. 177, 261-268, 2007.
  6. Ito M, Nagai T, Mizoguchi H, Fukakusa A, Nakanishi Y, Kamei H, Nabeshima T, Takuma K and Yamada K: Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system. J. Neurochem. 101, 1392-1399, 2007.
  7. Nagai T, Takuma K, Kamei H, Ito Y, Nakamichi N, Ibi D, Nakanishi Y, Murai M, Mizoguchi H, Nabeshima T and Yamada K: Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex. Learn Mem. 14, 117-125, 2007.
  8. Takuma K, Matsuo A, Himeno Y, Hoshina Y, Ohno Y, Funatsu Y, Arai S, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K: 17β-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats. Neuroscience 146, 60-68, 2007.
  9. Yan Y, Yamada K, Mizoguchi H, Noda Y, Nagai T, Nitta A and Nabeshima T: Reinforcing effects of morphine are reduced in tissue plasminogen activator (tPA)-knockout mice. Neuroscience 146, 50-59, 2007.
  10. Maeda K, Sugino H, Hirose T, Kitagawa H, Nagai T, Mizoguchi H, Takuma K and Yamada K: Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine. J. Pharmacol. Sci. 103, 299-308, 2007.
  11. Matsuya T, Takuma K, Sato K, Asai M, Murakami Y, Miyoshi S, Noda A, Nagai T, Mizoguchi H, Nishimura S and Yamada K: Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-Hydroxydopamine-induced hemi-Parkinsonian mouse model. J. Pharmacol. Sci. 103, 329-332, 2007.
  12. Yan Y, Yamada K, Niwa M, Nagai T, Nitta A and Nabeshima T: Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice. FASEB J. 21, 1994-2004, 2007.
  13. Mizoguchi H, Yamada K, Mouri A, Niwa M, Mizuno T, Noda Y, Nitta A, Itohara S, Banno Y and Nabeshima T: Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implication for dopamine receptor down-regulation and dopamine release. J. Neurochem. 102, 1548-1560, 2007.
  14. Nagai T, Takuma K, Dohniwa M, Ibi D, Mizoguchi H, Kamei H, Nabeshima T and Yamada K: Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol. Psychopharmacology (Berl) 194, 21-32, 2007.
  15. Takuma K, Hoshina, Y, Arai S, Himeno Y, Matsuo, A, Funatsu Y, Kitahara Y, Ibi, D, Hayase M, Kamei H, Mizoguchi H, Nagai T, Koike K, Inoue M and Yamada K: Ginkgo biloba extract EGb761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Neuroscience 149, 256-262, 2007.
  16. Takano K, Kitao Y, Tabata Y, Miura H, Sato K, Takuma K, Yamada K, Hibino S, Choshi T, Iinuma M, Suzuki H, Murakami R, Yamada M, Ogawa S and Hori O: A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum (ER) stress. Am. J. Physiol.Cell Physiol. 293, 1884-1894, 2007.
  17. Ito M, Nagai T, Mizoguchi H, Sato K, Hayase M, Otsuka N, Fukakusa A, Kumagai N, Kim H-C, Nabeshima T, Takuma K and Yamada K: Activation of post-synaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling. J. Neurochem. 103, 2589-2596, 2007.
  18. Shin EJ, Jeong JH, Kim HJ, Jang CG, Yamada K, Nabeshima T and Kim HC: Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice. J. Pharmacol. Sci. 105, 367-371, 2007.
  19. Niwa M, Nitta A, Yamada K and Nabeshima T: The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-?, and an inducer of these factors in drug dependence [review]. J. Pharmacol. Sci. 104, 116-121, 2007.

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