IntSplice predicts a splicing consequence of a single nucleotide variation (SNV) at intronic positions -50 to -3 close to the 3' end of an intron of the human genome. Compared to our previous ver. 1.0, ver. 1.1 has a different user interface and is much faster. Note that the predicted value of ver. 1.1 is slightly different from that of ver. 1.0 to expedite the calculation. Pre-processed genome-wide scores of IntSplice ver. 1.1 are available under the “Download” tab.