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Department of NeuroscienceNeuropharmacology

Introduction

under construction

Research Projects

under construction

Faculty Members

FacultyPositionDepartment
Masaki Fukata Professor Neuropharmacology
Yuko Fukata Associate Professor Molecular and Cellular Pharmacology
Norihiko Yokoi Assistant Professor Neuropharmacology
Yuri Miyazaki Assistant Professor Neuropharmacology
Keisuke Kuroda Designated Associate Professor Promotion Office for WISE Programs/Neuropharmacology

Bibliography

  • 2023
    1. Zhang X, Kira JI, Ogata H, Imamura T, Mitsuishi M, Fujii T, Kobayashi M, Kitagawa K, Namihira Y, Ohya Y, Maimaitijiang G, Yamasaki R, Fukata Y, Fukata M, Isobe N, Nakamura Y.Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy.Neurol Neuroimmunol Neuroinflamm. 10:e200081 (2023)doi: 10.1212/NXI.0000000000200081.PubMed 36631269
    2. Nosková R*, Fukata Y*, Stránecký V, Šaligová J, Bodnárová O, Giertlová M, Fukata M**, Kmoch S** (*, equally contributed; **, corresponding authors). ADAM22 ethnic-specific variant reducing binding of membrane-associated guanylate kinases causes focal epilepsy and behavioural disorder. Brain Commun (2023). doi.org/10.1093/braincomms/fcad295.
    3. Miyazaki Y, Otsuka O, Yamagata Y, Endo T, Sanbo M, Sano H, Kobayashi K, Inahashi H, Kornau H-C, Schmitz D, Prüss H, Meijer D, Hirabayashi M, Fukata Y*, Fukata M* (*, corresponding authors). Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports (2023). doi.org/10.1016/j.celrep.2023.113634
  • 2022
    1. Niki Y, Adachi N, Fukata M, Fukata Y, Oku S, Makino-Okamura C, Takeuchi S, Wakamatsu K, Ito S, Declercq L, Yarosh D B, Mammone T, Nishigori C, Saito N, Ueyama T S-palmitoylation of tyrosinase at cysteine500 regulates melanogenesis J Invest Dermatol (2022) doi: 10.1016/j.jid.2022.08.040 PubMed 36063887
    2. van der Knoop MM*, Maroofian R*, Fukata Y*, van Ierland Y, Karimiani EG, Lehesjoki AE, Muona M, Paetau A, Miyazaki Y, Hirano Y, Selim L, de França M, Fock RA, Beetz C, Ruivenkamp CAL, Eaton AJ, Morneau-Jacob FD, Sagi-Dain L, Shemer-Meiri L, Peleg A, Haddad-Halloun J, Kamphuis DJ, Peeters-Scholte CMPCD, Hiz Kurul S, Horvath R, Lochmüller H, Murphy D, Waldmüller S, Spranger S, Overberg D, Muir AM, Rad A, Vona B, Abdulwahad F, Maddirevula S, Povolotskaya IS, Voinova VY, Gowda VK, Srinivasan VM, Alkuraya FS, Mefford HC, Alfadhel M, Haack TB, Striano P, Severino M, Fukata M**, Hilhorst-Hofstee Y**, Houlden H**. (*, equally contributed; **, corresponding authors) Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset refractory epilepsy. Brain (2022) doi: 10.1093/brain/awac116. PubMed 35373813
    3. Kawai T, Narita H, Konno K, Akter S, Andriani RT, Iwasaki H, Nishikawa S, Yokoi N, Fukata Y, Fukata M, Wiriyasermkul P, Kongpracha P, Nagamori S, Takao K, Miyakawa T, Abe M, Sakimura K, Watanabe M, Nakagawa A, Okamura Y. Insight into the function of a unique voltage-sensor protein (TMEM266) and its short form in mouse cerebellum Biochem J (2022) doi: 10.1042/BCJ20220033 PubMed 35574701
    4. Wirth A, Labus J, Galil DA, Schill Y, Schmidt S,Bunke T, Gorinski N, Yokoi N, Fukata M, Ponimaskin E Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine formation and gene transcription J Biol Chem (2022) doi: 10.1016/j.jbc.2022.102048 PubMed 35597282
  • 2021
    1. Fukata Y, Chen X, Chiken S, Hirano Y, Yamagata A, Inahashi H, Sanbo M, Sano H, Goto T, Hirabayashi M, Kornau HC, Prüss H, Nambu A, Fukai S, Nicoll RA, Fukata M. LGI1-ADAM22-MAGUK configures trans-synaptic nanoalignment for synaptic transmission and epilepsy prevention Proc Natl Acad Sci USA. 118:e2022580118 (2021) doi.org/10.1073/pnas.2022580118 PubMed 33397806
    2. Yokoi N, Fukata Y*, Okatsu K, Yamagata A,Liu Y, Sanbo M, Miyazaki Y, Goto T, Abe M, Kassai H, Sakimura K, Meijer D, Hirabayashi M, Fukai S, Fukata M* 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice. Cell Rep 37:110107 (2021) doi.org/10.1016/j.celrep.2021.110107 PubMed 34910912
    3. Nakamoto C, Goto Y, Tomizawa Y, Fukata Y, Fukata M, Harpsøe K, Gloriam DE, Aoki K, Takeuchi T. A novel red fluorescence dopamine biosensor selectively detects dopamine in the presence of norepinephrine in vitro. Mol Brain 14:173 (2021) doi.org/10.1186/s13041-021-00882-8 PubMed 34872607
    4. Kreye J, Wright SK, van Casteren A, Stöffler L, Machule ML, Reincke SM, Nikolaus M, van Hoof S, Sanchez-Sendin E, Homeyer MA, Gómez CC, Kornau HC, Schmitz D, Kaindl AM, Boehm-Sturm P, Mueller S, Wilson MA, Upadhya MA, Dhangar DR, Greenhill S, Woodhall G, Turko P, Vida I, Garner CC, Wickel J, Geis C, Fukata Y, Fukata M, Prüss H. Encephalitis patient-derived monoclonal GABAA receptor antibodies cause epileptic seizures J Exp Med 218:e20210012 (2021) doi.org/10.1084/jem.20210012PubMed 34546336
    5. Chen X, Fukata Y, Fukata M, Nicoll R. MAGUKs are essential, but redundant, in long-term potentiation Proc Natl Acad Sci USA. 118:e2107585118 (2021) doi: 10.1073/pnas.2107585118 PubMed 34244435
    6. Fukata Y, Hirano Y, Miyazaki Y, Yokoi N, Fukata M. Trans-synaptic LGI1-ADAM22-MAGUK in AMPA and NMDA receptor regulation Neuropharmacology (2021) doi: 10.1016/j.neuropharm.2021.108628 PubMed 34089731
    7. Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, Saitoh T, Maenaka K, Shimada T, Fukata Y, Fukata M, Matsumoto J, Nishijo H, Takao K, Tanaka S, Okabe S, Tabuchi K, Uemura T, Mishina M, Mori H, Fukai S. Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice Nat Commun. 2021 12:1848. doi: 10.1038/s41467-021-22059-6. PubMed 33758193
  • 2020
    1. Watanabe H, Sano H, Chiken S, Kobayashi K, Fukata Y, Fukata M, Mushiake H, Nambu A. Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex. Nat Commun 11:3253 (2020) doi: 10.1038/s41467-020-16883-5 PubMed 32591505
    2. Oda Y, Sugawara T, Fukata Y, Izumi Y, Otani Y, Higashi T, Fukata M, Furuse M The extracellular domain of angulin-1 and palmitoylation of its cytoplasmic region are required for angulin-1 assembly at tricellular contacts J Biol Chem 295:4289-4302 (2020) doi:10.1074/jbc.RA119.010491 PubMed 32079676
    3. Kornau HC, Kreye J, Stumpf A, Fukata Y, Parthier D, Sammons RP, Imbrosci B, Kurpjuweit S, Kowski AB, Fukata M, Prüss H, Schmitz D. Human CSF monoclonal LGI1 autoantibodies increase neuronal excitability Ann Neurol 87(3):405-418 (2020) doi: 10.1002/ana.25666 PubMed 31900946
  • 2019
    1. Sada R, Kimura H, Fukata Y, Fukata M, Yamamoto H, Kikuchi A. Dynamic palmitoylation determines microdomain localization of two DKK1 receptors, CKAP4 and LRP6, and regulates DKK1 signaling. Sci Signaling 12:eaat9519 (2019) doi: 10.1126/scisignal.aat9519 PubMed 31744930
    2. Cao Y, Qiu T, Kathayat R, Azizi SA, Fukata Y, Fukata M, Rice P, Dickinson BC. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 Nat Chem Biol 15:1232-1240 (2019) doi: 10.1038/s41589-019-0399-y PubMed 31740833
    3. Boncompain G, Herit F, Tessier S, Lescure A, Del Nery E, Gestraud P, Staropoli I, Fukata Y, Fukata M, Brelot A, Niedergang F, Perez F. Targeting CCR5 trafficking to inhibit HIV-1 infection Science Advances 5:eaax0821 (2019) doi: 10.1126/sciadv.aax0821 PubMed 31663020
    4. Kanadome T, Yokoi N, Fukata Y, Fukata M. Systematic Screening of Depalmitoylating Enzymes and Evaluation of Their Activities by the Acyl-PEGyl Exchange Gel-Shift (APEGS) Assay Methods Mol Biol 2009:83-98 (2019) doi: 10.1007/978-1-4939-9532-5_7 PubMed 31152397
    5. Hasegawa D, Ohnishi Y, Koyama E, Matsunaga S, Ohtani S, Nakanishi A, Shiga T, Chambers JK, Uchida K, Yokoi N, Fukata Y, Fukata M. Deleted in colorectal cancer (netrin-1 receptor) antibodies and limbic encephalitis in a cat with hippocampal necrosis J Vet Intern Med 33:1440-1445 (2019) doi: 10.1111/jvim.15492 PubMed 30942925
  • 2018
    1. Yamagata A*, Miyazaki Y*, Yokoi N, Shigematsu H, Sato Y, Goto-Ito S, Maeda A, Goto T, Sanbo M, Hirabayashi M, Shirouzu M, Fukata Y, Fukata M**, Fukai S**. (*, equally contributed; **, corresponding authors) Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22 Nat Commun 9:1546 (2018) doi: 10.1038/s41467-018-03947-w PubMed 29670100
    2. Yoshikura N, Kimura A, Fukata M, Fukata Y, Yokoi N, Harada N, Hayashi Y, Inuzuka T, Shimohata T. Long-term clinical follow-up of a patient with non-paraneoplastic cerebellar ataxia associated with anti-mGluR1 autoantibodies J Neuroimmunol 319:63-67 (2018) doi: 10.1016/j.jneuroim.2018.04.001 PubMed 29685291
    3. Fukata M, Yokoi N, Fukata Y. Neurobiology of autoimmune encephalitis. Curr Opin Neurobiol 48:1-8 (2018) doi: 10.1016/j.conb.2017.07.012 PubMed 28829986
  • 2017
    1. Fukata Y, Fukata M. Epilepsy and synaptic proteins. Curr Opin Neurobiol, 45:1-8 (2017) doi: 10.1016/j.conb.2017.02.001 PubMed 28219682
    2. Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y. Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation. J Physiol (2017) doi: 10.1113/JP274871 PubMed 28715108
    3. Tortosa E, Adolfs Y, Fukata M, Pasterkamp RJ, Kapitein LC, Hoogenraad CC. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron 94:809-825 (2017) doi: 10.1016/j.neuron.2017.04.042 PubMed 28521134
    4. Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M. Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin. J Neurosci 37:3181-3191 (2017) doi: 10.1523/JNEUROSCI.3632-16.2017 PubMed 28213441
    5. Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T. In situ screening for postsynaptic cell adhesion molecules during synapse formation. J Biochem (2017) doi: 10.1093/jb/mvx030 PubMed 28449070
    6. Cho T, Ishii-Kato A, Fukata Y, Nakayama Y, Iida K, Fukata M, Iida H. Coupling of a voltage-gated Ca2+ channel homolog with a plasma membrane H+-ATPase in yeast. Genes to Cells 22:94-104 (2017) doi: 10.1111/gtc.12458 PubMed 27935186
    7. Sugio S, Tohyama K, Oku S, Fujiyoshi K, Yoshimura T, Hikishima K, Yano R, Fukuda T, Nakamura M, Okano H, Watanabe M1, Fukata M, Ikenaka K, F Tanaka K. Astrocyte-mediated infantile-onset leukoencephalopathy mouse model. Glia 65:150-168 (2017) doi: 10.1002/glia.23084 PubMed 27748972
  • 2016
    1. Fukata Y, Yokoi N, Miyazaki Y, Fukata M. The LGI1-ADAM22 protein complex in synaptic transmission and synaptic disorders. Neurosci Res 116:39-45 (2016) doi: 10.1016/j.neures.2016.09.011. PubMed 27717669
    2. Yokoi N*, Fukata Y*, Sekiya A, Murakami T, Kobayashi K, Fukata M. Identification of PSD-95 Depalmitoylating Enzymes. J Neurosci 36:6431-44 (2016) doi:10.1523/JNEUROSCI.0419-16.2016 PubMed 27307232
    3. Muona M, Fukata Y, Anttonen AK, Laari A, Palotie A, Pihko H, Lﾃｶnnqvist T, Valanne L, Somer M, Fukata M, Lehesjoki AE. Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy. Neurol Genet 2:e46 (2016) doi: 10.1212/NXG.0000000000000046 PubMed 27066583
    4. Fukata Y, Murakami T, Yokoi N, Fukata M. Local Palmitoylation Cycles and Specialized Membrane Domain Organization. Curr Top Membr 77:97-141 (2016) doi: 10.1016/bs.ctm.2015.10.003 PubMed 26781831
  • 2015
    1. Lovero KL, Fukata Y, Granger AJ, Fukata M, Nicoll RA. The LGI1-ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function. Proc Natl Acad Sci USA. 112:E4129-E4137 (2015) doi: 10.1073/pnas.1511910112 PubMed 26178195
    2. Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy. Nat Med 21:19-26 (2015) doi:10.1038/nm.3759 PubMed 25485908
    3. Fukata M, Sekiya A, Murakami T, Yokoi N, Fukata Y. Postsynaptic nanodomains generated by local palmitoylation cycles. Biochem Soc Trans 43:199-204 (2015) doi: 10.1042/BST20140238 PubMed 25849917
    4. Suzuki M, Murakami T, Cheng J, Kano H, Fukata M, Fujimoto T. ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment. Mol Biol Cell 26:2333-2342 (2015) doi: 10.1091/mbc.E14-11-1504 PubMed 25904333
    5. Zhu D, Li C, Swanson AM, Villalba RM, Guo J, Zhang Z, Matheny S, Murakami T, Stephenson JR, Daniel S, Fukata M, Hall RA, Olson JJ, Neigh GN, Smith Y, Rainnie DG, Van Meir EG. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest 125:1497-1508 (2015) doi: 10.1172/JCI74603 PubMed 25751059
  • 2014
    1. Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, Fukata Y, Fukata M. Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis. J Neurosci 34:8151-8163 (2014) doi: 10.1523/JNEUROSCI.4415-13.2014 PubMed 24920620
    2. Kegel L, Jaegle M, Driegen S, Aunin E, Leslie K, Fukata Y, Watanabe M, Fukata M, Meijer D. Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination. Development 141:1749-1756 (2014) doi: 10.1242/dev.107995 PubMed 24715463
    3. Gory-Fauré S, Windscheid V, Brocard J, Montessuit S, Tsutsumi R, Denarier E, Fukata Y, Bosc C, Delaroche J, Collomb N, Fukata M, Martinou JC, Pernet-Gallay K, Andrieux A. Non-microtubular localizations of microtubule-associated protein 6 (MAP6). PLoS One 9:e114905 (2014) doi:10.1371/journal.pone.0114905 PubMed 25526643
  • 2013
    1. Ohkawa T, Fukata Y, Yamasaki M, Miyazaki T, Yokoi N, Takashima H, Watanabe M, Watanabe O, Fukata M. Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors. J Neurosci 33:18161-18174 (2013) doi: 10.1523/JNEUROSCI.3506-13.2013 PubMed 24227725
    2. Fukata Y, Dimitrov A, Boncompain G, Vielemeyer O, Perez F, Fukata M. Local palmitoylation cycles define activity-regulated postsynaptic subdomains J Cell Biol 202:145-161 (2013) doi: 10.1083/jcb.201302071 PubMed 23836932
    3. Oku S, Takahashi N, Fukata Y, Fukata M. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes J Biol Chem 288:19816-19829 (2013) doi: 10.1074/jbc.M112.431676 PubMed 23687301
    4. Zheng B, DeRan M, Li X, Liao X, Fukata M, Wu X. 2-Bromopalmitate analogues as activity-based probes to explore palmitoyl acyltransferases. J Am Chem Soc 135:7082-7085 (2013) doi: 10.1021/ja311416v PubMed 23631516
    5. Kawahara A, Kurauchi S, Fukata Y, Martínez-Hernández J, Yagihashi T, Itadani Y, Sho R, Kajiyama T, Shinzato N, Narusuye K, Fukata M, Lujﾃ｡n R, Shigemoto R, Ito I. Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry. J Physiol 591:4777-4791 (2013) PubMed 23878366
  • 2012
    1. Yokoi N,Fukata M, Fukata Y. Synaptic plasticity regulated by protein-protein interactions and posttranslational modifications.
    2. Int Rev Cell Mol Biol 297:1-43 (2012) doi: 10.1016/B978-0-12-394308-8.00001-7 PubMed 22608556
    3. Kusuzawa S, Honda T, Fukata Y, Fukata M, Kanatani S, Tanaka DH, Nakajima K. Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons. Eur J Neurosci 36:2284-2292 (2012) doi: 10.1111/j.1460-9568.2012.08129.x PubMed 22612501
    4. Lu D, Sun HQ, Wang H, Barylko B, Fukata Y, Fukata M, Albanesi JP, Yin HL. Phosphatidylinositol 4-kinase IIα is palmitoylated by Golgi-localized palmitoyltransferases in cholesterol-dependent manner. J Biol Chem 287:21856-21865 (2012) doi: 10.1074/jbc.M112.348094 PubMed 22535966
    5. Oku S, Fukata Y, and Fukata M. DHHC proteins. Encyclopedia of Signaling Molecules. Edited by Choi, S., 1st Edition, Springer (2012) ISBN 978-1-4419-0460-7
  • 2011
    1. Seppälä EH, Jokinen TS, Fukata M, Fukata Y, Webster MT, Karlsson EK, Kilpinen SK, Steffen F, Dietschi E, Leeb T, Eklund R, Zhao X, Rilstone JJ, Lindblad-Toh K, Minassian BA, Lohi H. LGI2 truncation causes a remitting focal epilepsy in dogs. PLoS Genetics 7:e1002194 (2011) doi: 10.1371/journal.pgen.1002194 PubMed 21829378
    2. Levy AD, Devignot V, Fukata Y, Fukata M, Sobel A, Chauvin S. Subcellular Golgi localization of stathmin family proteins is promoted by a specific set of DHHC palmitoyl transferases. Mol Biol Cell 22:1930-1942 (2011) doi: 10.1091/mbc.E10-10-0824 PubMed 21471001
  • 2010
    1. Fukata Y, Fukata M. Protein palmitoylation in neuronal development and synaptic plasticity. Nat Rev Neurosci 11:161-175 (2010) doi: 10.1038/nrn2788. PubMed 20168314
    2. Fukata Y, Lovero KL, Iwanaga T, Watanabe A, Yokoi N, Tabuchi K, Shigemoto R, Nicoll RA, Fukata M. Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy. Proc Natl Acad Sci USA 107:3799-3804 (2010) doi: 10.1073/pnas.0914537107 PubMed 20133599s
  • 2009
    1. Noritake J, Fukata Y, Iwanaga T, Hosomi N, Tsutsumi R, Matsuda N, Tani H, Iwanari H, Mochizuki Y, Kodama T, Matsuura Y, Bredt DS, Hamakubo T, Fukata M Mobile DHHC palmitoylating enzyme mediates activity-sensitive synaptic targeting of PSD-95. J Cell Biol 186:147-160 (2009) doi: 10.1083/jcb.200903101 PubMed 19596852
    2. Iwanaga T, Tsutsumi R, Noritake J, Fukata Y, Fukata M. Dynamic protein palmitoylation in cellular signaling. Prog Lipid Res 48:117-127 (2009) doi: 10.1016/j.plipres.2009.02.001 PubMed 19233228
    3. Tsutsumi R, Fukata Y, Noritake J, Iwanaga T, Perez F, Fukata M. Identification of G protein alpha subunit-palmitoylating enzyme. Mol Cell Biol 29:435-447 (2009) doi: 10.1128/MCB.01144-08 PubMed 19001095
    4. Matsuda N, Lu H, Fukata Y, Noritake J, Gao H, Mukherjee S, Nemoto T, Fukata M, Poo MM. Differential activity-dependent secretion of brain-derived neurotrophic factor from axon and dendrite. J Neurosci 29:14185-14198 (2009) doi: 10.1523/JNEUROSCI.1863-09 PubMed 19906967
    5. Shmueli A, Segal M, Sapir T, Tsutsumi R, Noritake J, Bar A, Sapoznik S. Fukata Y, Orr I Fukata M, Reiner O. Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. EMBO J 29:107-119 (2010) doi: 10.1038/emboj.2009.325 PubMed 19927128
    6. Mill P, Lee AW, Fukata Y, Tsutsumi R, Fukata M, Keighren M, Porter RM, McKie L, Smyth I, Jackson IJ. Palmitoylation regulates epidermal homeostasis and hair follicle differentiation PLoS Genet 5:e1000748 (2009) doi: 10.1371/journal.pgen.1000748 PubMed 19956733
    7. Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem 284:3793-3803 (2009) doi: 10.1074/jbc.M808920200 PubMed 19074428
    8. Greaves J, Prescott GR, Fukata Y, Fukata M, Salaun C, Chamberlain LH. The hydrophobic cysteine-rich domain of SNAP25 couples with downstream residues to mediated membrane interactions and recognitions by DHHC palmitoyl transferases. Mol Biol Cell 20:1845-1854 (2009) doi: 10.1091/mbc.E08-09-0944 PubMed 19158383
  • 2008
    1. Ponimaskin E, Dityateva G, Ruonala MO, Fukata M, Fukata Y, Kobe F, Wouters FS, Delling M, Bredt DS, Schachner M, Dityatev A. Fibroblast growth factor-regulated palmitoylation of the neural cell adhesion molecule determines neuronal morphogenesis. J Neurosci 28:8897-8907 (2008) doi: 10.1523/JNEUROSCI.2171-08 PubMed 18768683
    2. Greaves J, Salaun C, Fukata Y, Fukata M, Chamberlain LH. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem 283:25014-25026 (2008) doi: 10.1074/jbc.M802140200 PubMed 18596047
    3. Tsutsumi R, Fukata Y, Fukata M. Discovery of protein-palmitoylating enzymes. Pflugers Arch 456:1199-1206 (2008) doi: 10.1007/s00424-008-0465-x PubMed 18231805
  • 2007
    1. Olsen O, Funke L, Long JF, Fukata M, Kazuta T, Trinidad JC, Moore KA, Misawa H, Welling PA, Burlingame AL, Zhang M, Bredt DS. Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice. J Cell Biol 179:151-164 (2007) PubMed 17923534
    2. Mishima M, Maesaki R, Kasa M, Watanabe T, Fukata M, Kaibuchi K, Hakoshima T. Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. Proc Natl Acad Sci USA 104:10346-10351 (2007) PubMed 17563362
    3. Yamamoto N, Fukata Y, Fukata M, Yanagisawa K. GM1-ganglioside-induced Abeta assembly on synaptic membranes of cultured neurons. Biochim Biophys Acta 1768:1128-1137 (2007) PubMed 17306220
    4. Wang S, Watanabe T, Noritake J, Fukata M, Yoshimura T, Itoh N, Harada T, Nakagawa M, Matsuura Y, Arimura N, Kaibuchi K. IQGAP3, a novel effector of Rac1 and Cdc42, regulates neurite outgrowth. J Cell Sci 120:567-577 (2007) PubMed 17244649
    5. Tomita S, Shenoy A, Fukata Y, Nicoll RA, Bredt DS. Stargazin interacts functionally with the AMPA receptor glutamate-binding module. Neuropharmacology 52:87-91 (2007) PubMed 16919685
  • 2006
    1. Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science 313:1792-1795 (2006) PubMed 16990550
    2. Fukata Y, Iwanaga T, Fukata M. Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Methods 40:177-182 (2006) PubMed 17012030
    3. Fang C, Deng L, Keller CA, Fukata M, Fukata Y, Chen G, Lüscher B. GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci 26:12758-12768 (2006) PubMed 17151279
    4. Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. J Cell Biol 174:369-377 (2006) PubMed 16864653
    5. Hundt M, Tabata H, Jeon MS, Hayashi K, Tanaka Y, Krishna R, De Giorgio L, Liu YC, Fukata M, Altman A. Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect. Immunity 24:513-522 (2006) PubMed 16713970
    6. Fukata Y, Bredt DS, Fukata M. Protein palmitoylation by DHHC protein family. The CRC Press: The Dynamic Synapse: Molecular Methods in Ionotropic Receptor Biology. 81-88 (2006) PubMed 81-88
  • 2005
    1. Fukata Y, Tzingounis AV, Trinidad JC, Fukata M, Burlingame AL, Nicoll RA, Bredt DS. Molecular constituents of neuronal AMPA receptor. J Cell Biol 169:399-404 (2005) PubMed 15883194
    2. Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad J, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS. Neurotransmitter release regulated by a MALS-liprin-a presynaptic complex. J Cell Biol 170:1127-1134 (2005) PubMed PMC2171538
    3. Arimura N, Ménager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M, Goshima Y, Inagaki M, Morone N, Usukura J, Kaibuchi K. Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones. Mol Cell Biol 25: 9973-9984 (2005) PubMed 16260611
    4. Kimura T, Arimura N, Fukata Y, Watanabe H, Iwamatsu A, Kaibuchi K. Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem 93: 1371-1382 (2005) PubMed 15935053
  • 2004
    1. Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS. Identification of PSD-95 Palmitoylating Enzymes. Neuron 44:987-996 (2004) PubMed 15603741
    2. Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 6:871-883 (2004) PubMed 15572129
    3. Tomita S, Fukata M, Nicoll RA, Bredt DS. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses. Science 303:1508-1511 (2004) PubMed 15001777
    4. Noritake J, Fukata M, Sato K, Nakagawa M, Watanabe T, Izumi N, Wang S, Fukata Y, Kaibuchi K. Positive Role of IQGAP1, an Effector of Rac1, in Actin-Meshwork Formation at Sites of Cell-Cell Contact. Mol Biol Cell 3:1065-1076 (2004) PubMed 14699063
    5. Mélnager C, Arimura N, Fukata Y, Kaibuchi K. PIP3 is involved in neuronal polarization and axon formation. J Neurochem 89:109-118 (2004) PubMed 15030394
    6. Arimura N, Menager C, Fukata Y, Kaibuchi K. Role of CRMP-2 in neuronal polarity. J Neurobiol 58:34-47 (2004) PubMed 14598368
    7. Nishimura T, Kato K, Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K. Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nature Cell Biol 6:328-334 (2004) PubMed 15048131
  • 2003
    1. Fukata M, Nakagawa M, Kaibuchi K. Roles of Rho-family GTPases in cell polarisation and directional migration Curr Opin Cell Biol 15:590-597 (2003) PubMed 14519394
    2. Amano M, Kaneko T, Maeda A, Nakayama M, Ito M, Yamauchi T, Goto H, Fukata Y, Oshiro N, Shinohara A, Iwamatsu A, Kaibuchi K. Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem 87:780-790 (2003) PubMed 14535960
    3. Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, Kaibuchi K. CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nature Cell Biol 5:819-826 (2003) PubMed 12942088
  • 2002
    1. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K. Rac1 and Cdc42 Capture Microtubules through IQGAP1 and CLIP-170. Cell 109:873-885 (2002) PubMed 12110184
    2. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. Effects of Rho family GTPases on cell-cell adhesion. Methods Mol Biol 189:121-128 (2002) PubMed 12094580
    3. Fukata Y, Itoh TJ, Kimura T, Ménager C, Nishimura T, Shiromizu T, Watanabe H, Inagaki N, Iwamatsu A, Hotani H, Kaibuchi K. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nature Cell Biol 4:583-591 (2002) PubMed 12134159
    4. Fukata Y, Kimura T, Kaibuchi K. Axon specification in hippocampal neurons. Neuroscience Res 43: 305-315 (2002) PubMed 12135774
    5. Maeda A, Amano M, Fukata Y, Kaibuchi K. Translocation of Na(+),K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells. Biochem Biophys Res Commun 297:1231-1237 (2002) PubMed 12372419
  • 2001
    1. Fukata M, Kaibuchi K. Rho-family GTPases in cadherin-mediated cell-cell adhesion. Nature Reviews Mol Cell Biol 12:887-897 (2001) PubMed 11733768
    2. Fukata M, Nakagawa M, Itoh N, Kawajiri A, Yamaga M, Kuroda S, Kaibuchi K. Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering. Mol Cell Biol 21:2165-2183 (2001) PubMed 11238950
    3. Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trend Pharmacol Sci 22:32-39 (2001) PubMed 11165670
    4. Nakagawa M, Fukata M, Yamaga M, Itoh N, Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin- mediated cell-cell adhesion sites. J Cell Sci 114:1829-1838 (2001) PubMed 11329369
  • 2000
    1. Amano M, Fukata Y, Shimokawa H, Kaibuchi K. Purification and in Vitro Activity of Rho-Associated Kinase. Methods Enzymol 325:149-155 (2000) PubMed 11036600
    2. Amano M, Fukata Y, Kaibuchi K. Regulation and Functions of Rho-Associated Kinase. Exp Cell Res 261:44-51 (2000) PubMed 11082274
    3. Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K. Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun 278:72-78 (2000) PubMed 11071857
    4. Kawajiri A, Itoh N, Fukata M, Nakagawa M, Yamaga M, Iwamatsu A, Kaibuchi K. Identification of a novel beta-catenin-interacting protein. Biochem Biophys Res Commun 273:712-717 (2000) PubMed 10873669
    5. Nakamura N, Oshiro N, Fukata Y, Amano M, Fukata M, Kuroda S, Matsuura Y, Leung T, Lim L, Kaibuchi K. Phosphorylation of ERM proteins at filopodia induced by Cdc42. Genes Cells 5:571-581 (2000) PubMed 10947843
    6. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C. Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127:4157-4168 (2000) PubMed 10976048
    7. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K, Takeshita A. Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation 101:1319-1323 (2000) PubMed 10725293
  • 1999
    1. Fukata M, Nakagawa M, Kuroda S, Kaibuchi K. Cell adhesion and Rho small GTPases. J Cell Sci 112:4491-4500 (1999) PubMed 10574699
    2. Fukata M, Kuroda S, Nakagawa M, Kawajiri A, Itoh N, Shoji I, Matsuura Y, Yonehara S, Fujisawa H, Kikuchi A, Kaibuchi K. Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin. J Biol Chem 274:26044-26050 (1999) PubMed 10473551
    3. Fukata Y, Oshiro N, Kinoshita N, Kawano Y, Matsuoka Y, Bennett V, Matsuura Y, Kaibuchi K. Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility. J Cell Biol 145:347-361 (1999) PubMed 10209029
    4. Fukata Y, Oshiro N, Kaibuchi K. Activation of moesin and adducin by Rho-kinase downstream of Rho. Biophys Chem 82:139-147 (1999) PubMed 10631797
    5. Kuroda S, Fukata M, Nakagawa M, Kaibuchi K. Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion. Biochem Biophys Res Commun 262:1-6 (1999) PubMed 10448058
    6. Kawano Y, Fukata Y, Oshiro N, Amano M, Nakamura T, Ito M, Matsumura F, Inagaki M, Kaibuchi K. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol 147:1023-1038 (1999) PubMed 10579722
    7. Hoshino M, Sone M, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C. Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. J Biol Chem 274:17837-17844 (1999) PubMed 10364228
    8. Kaibuchi K, Kuroda S, Fukata M, Nakagawa M. Regulation of cadherin-mediated cell-cell adhesion by the Rho family GTPases. Curr Opin Cell Biol 11:591-596 (1999) PubMed 10508646
  • 1998
    1. Fukata Y, Kimura K, Oshiro N, Saya H, Matsuura Y, Kaibuchi K. Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-kinase and myosin phosphatase. J Cell Biol 141:409-418 (1998) PubMed 9548719
    2. Kuroda S, Fukata M, Nakagawa M, Fujii K, Nakamura T, Ookubo T, Izawa I, Nagase T, Nomura N, Tani H, Shoji I, Matsuura Y, Yonehara S, Kaibuchi K. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin-mediated cell-cell adhesion. Science 281:832-835 (1998) PubMed 9694656
    3. Kimura K, Fukata Y, Matsuoka Y, Bennett V, Matsuura Y, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of the association of adducin with actin filaments by Rho-kinase and myosin phosphatase. J Biol Chem 273:5542-5548 (1998) PubMed 9488679
    4. Oshiro N, Fukata Y, Kaibuchi K. Phosphorylation of Moesin by Rho-associated Kinase (Rho-kinase) Plays a Crucial Role in the Formation of Microvilli-like Structures. J Biol Chem 273:34663-34666 (1998) PubMed 9856983
    5. Amano M, Fukata Y, Kaibuchi K. Regulation of Cytoskeleton and Cell Adhesions by the Small GTPase Rho and Its Targets. Trend Cardio Med 8:162-168 PubMed 21235928
    6. Amano M, Chihara K, Nakamura N, Fukata Y, Yano T, Shibata M, Ikebe M, Kaibuchi K. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cell 3:177-188 (1998) PubMed 9619630
    7. Kobayashi K, Kuroda S, Fukata M, Nakamura T, Nagase T, Nomura N, Matsuura Y, Yoshida-Kubomura N, Iwamatsu A, Kaibuchi K. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem 273:291-295 (1998) PubMed 9417078
  • 1997
    1. Fukata M, Kuroda S, Fujii K, Nakamura T, Shoji I, Matsuura Y, Okawa K, Iwamatsu A, Kikuchi A, Kaibuchi K. Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42. J Biol Chem 272:29579-29583 (1997) PubMed 9368021
    2. Kuroda S, Fukata M, Fujii K, Nakamura T, Izawa I, Kaibuchi K. Regulation of cell-cell adhesion of MDCK cells by Cdc42 and Rac1 small GTPases. Biochem. Biophys Res Commun 240:430-435 (1997) PubMed 9388496
    3. Amano M, Chihara K, Kimura K, Fukata Y, Nakamura N, Matsuura Y, Kaibuchi K. Formation of actin stress fibers and focal adhesions by Rho-kinase. Science 275:1308-1311 (1997) PubMed 9036856
  • 1996
    1. Kuroda S, Fukata M, Kobayashi K, Nakafuku M, Nomura N, Iwamatsu A, Kaibuchi K. Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem 271:23363-23367 (1996) PubMed 8798539
    2. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science 273:245-248 (1996) PubMed 8662509
    3. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 271:20246-20249 (1996) PubMed 8702756

Fukata Lab. Div. of Neuropharmacology

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