研究業績

Selected

  1. Tra NT#, Kiryu-Seo S#*, Kida H, Wakatsuki K, Tashiro Y, Tsutsumi M, Ataka M, Iguchi Y, Nemoto T, Takahashi R, Katsuno M, Kiyama H. Absence of the axon initial segment in sensory neuron enhances resistance to amyotrophic lateral sclerosis. Brain, in press. 

    DOI: 10.1093/brain/awaf182

  2. Nagata K*, Hashimoto S, Joho D, Fujioka R, Matsuba Y, Sekiguchi M, Mihira N, Motooka D, Liu YC, Okuzaki D, Kikuchi M, Murayama S, Saido TC, Kiyama H, Sasaguri H*: Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice. eNeuro 2024 ENEURO.0260-24, 2024. 
  3. Wakatsuki K, Kiryu-Seo S*, Yasui M, Yokota H, Kida H, Konishi H, Kiyama H*. Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice. J Neuroinflammation, 21(1), 25, 2024.
  4. Kiryu-Seo S*, Matsushita R, Tashiro R, Yoshimura T, Iguchi Y, Katsuno M, Ryosuke Takahashi R, Kiyama H*. Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons. EMBO J, 41, e110486, 2022.
  5. Jin M#, Matsumoto S#, Ayaki T#, Yamakado H, Taguchi T, Togawa N, Konno A, Hirai H, Nakajima H, Komai S, Ishida R, Chiba S, Takahashi R, Takao T, Hirotsune S. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nat Commun, 13(1) 6880, 2022.
  6. Tamada H, Kiryu-Seo S, Sawada S, Kiyama H. Axonal injury alters the extracellular glial environment of the axon initial segment and allows substantial mitochondrial influx into axon initial segment. J Comp Neurol, 529, 3621-3632, 2021. 
  7. Kiryu-Seo S*, Nagata K*, Saido TC and Kiyama H. New insights of a neuronal peptidase DINE/ECEL1: nerve development, nerve regeneration and neurogenic pathogenesis. Neurochem Res, 44 1279-1288, 2019. 
  8. Sasaguri H#, Nagata K#, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun, 9(1) 2892, 2018. 
  9. Nagata K*, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC*. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology. Nat Commun, 9(1) 1800, 2018.
  10. Kiryu-Seo S* and Kiyama H. Mitochondrial behavior during axon regeneration/degeneration in vivo. Neurosci Res, 139, 42-47, 2018. 
  11. Nagata K*, Takahashi M, Kiryu-Seo S, Kiyama H, Saido TC*. Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders. Acta Neuropathol Commun, 5(1):83, 2017.
  12. Kaneko A, Kiryu-Seo S*, Matsumoto S, Kiyama H*. Damage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury. Cell Death Dis, 8, e2847, 2017.
  13. Kiryu-Seo S*, Tamada H, Kato Y, Yasuda K, Ishihara N, Nomura M, Mihara K, Kiyama H*. Mitochondrial fission is an acute and adaptive response in injured motor neurons. Sci Rep, 6, 28331, 2016.
  14. Matsumoto S, Kiryu-Seo S*, Kiyama H*. Motor nerve arborization requires proteolytic domain of Damage-induced neuronal endopeptidase (DINE) during development. J Neurosci, 36, 4744-4757, 2016.
  15. Nagata K*, Kiryu-Seo S, Tamada H, Okuyama-Uchimura F, Kiyama H*, Saido TC*. ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis. Acta Neuropathol, 132, 111-126, 2016. 
  16. Kiryu-Seo S*, Kiyama H. The nuclear events guiding successful nerve regeneration. Front Mol Neurosci, 53, 2011.
  17. Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H. Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuro-muscular junctions. J Neurosci, 30, 6954-6962, 2010.
  18. Kiryu-Seo S, Ohno N, Kidd GJ, Komuro H, Trapp BD. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci, 30, 6658-6666, 2010.
  19. Gamo K, Kiryu-Seo S, Konishi H, Aoki S, Matsushima K, Wada K, Kiyama H.G-protein-coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity. J Neurosci, 28, 11980-11988, 2008.
  20. Kiryu-Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K, Kiyama H. Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. J Biol Chem, 283, 6988-96, 2008.
  21. Kiryu-Seo S, Gamo K, Tachibana T, Tanaka, K and Kiyama H. Unique anti-apoptotic activity of EAAC1 in injured motor neurons. EMBO J, 25, 3411-3421, 2006.
  22. Kiryu-Seo S, Hirayama T, Kato R, Kiyama H. Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse. J Neurosci, 25, 1442-1447, 2005.
  23. Nakagomi S, Suzuki Y, Namikawa K, Kiryu-Seo S, Kiyama H. Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. J Neurosci, 23, 5187-5196, 2003.
  24. Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S, Wada K, Kiyama H. Damage Induced Neuronal Endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Proc. Natl. Acad. Sci. USA, 97, 4345-4350, 2000.

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