研究業績

Selected

  1. Nagata K*, Hashimoto S, Joho D, Fujioka R, Matsuba Y, Sekiguchi M, Mihira N, Motooka D, Liu YC, Okuzaki D, Kikuchi M, Murayama S, Saido TC, Kiyama H, Sasaguri H*: Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice. eNeuro 2024 ENEURO.0260-24.2024. 
  2. Wakatsuki K, Kiryu-Seo S*, Yasui M, Yokota H, Kida H, Konishi H, Kiyama H*. Repeated cold stress, an animal model for fibromyalgia, elicits proprioceptor-induced chronic pain with microglial activation in mice. J Neuroinflammation, 21(1), 25, 2024.
  3. Kiryu-Seo S*, Matsushita R, Tashiro R, Yoshimura T, Iguchi Y, Katsuno M, Ryosuke Takahashi R, Kiyama H*. Impaired disassembly of the axon initial segment restricts mitochondrial entry into damaged axons. EMBO J, 41, e110486, 2022.
  4. Jin M#, Matsumoto S#, Ayaki T#, Yamakado H, Taguchi T, Togawa N, Konno A, Hirai H, Nakajima H, Komai S, Ishida R, Chiba S, Takahashi R, Takao T, Hirotsune S. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nat Commun 13(1) 6880, 2022.
  5. Tamada H, Kiryu-Seo S, Sawada S, Kiyama H. Axonal injury alters the extracellular glial environment of the axon initial segment and allows substantial mitochondrial influx into axon initial segment. J Comp Neurol, 529, 3621-3632, 2021. 
  6. Kiryu-Seo S*, Nagata K*, Saido TC and Kiyama H. New insights of a neuronal peptidase DINE/ECEL1: nerve development, nerve regeneration and neurogenic pathogenesis. Neurochem Res. 44 1279-1288, 2019. 
  7. Sasaguri H#, Nagata K#, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC. Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID. Nat Commun. 9(1) 2892, 2018. 
  8. Nagata K*, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC*. Generation of App knock-in mice reveals deletion mutations protective against Alzheimer’s disease-like pathology. Nat Commun 9(1) 1800, 2018.
  9. Kiryu-Seo S* and Kiyama H. Mitochondrial behavior during axon regeneration/degeneration in vivo. Neurosci Res, 139, 42-47, 2018. 
  10. Nagata K*, Takahashi M, Kiryu-Seo S, Kiyama H, Saido TC*. Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders. Acta Neuropathol Commun. 5(1):83, 2017.
  11. Kaneko A, Kiryu-Seo S*, Matsumoto S, Kiyama H*. Damage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury. Cell Death Dis, 8, e2847, 2017.
  12. Kiryu-Seo S*, Tamada H, Kato Y, Yasuda K, Ishihara N, Nomura M, Mihara K, Kiyama H*. Mitochondrial fission is an acute and adaptive response in injured motor neurons. Sci Rep, 6, 28331, 2016.
  13. Matsumoto S, Kiryu-Seo S*, Kiyama H*. Motor nerve arborization requires proteolytic domain of Damage-induced neuronal endopeptidase (DINE) during development. J Neurosci, 36, 4744-4757, 2016.
  14. Nagata K*, Kiryu-Seo S, Tamada H, Okuyama-Uchimura F, Kiyama H*, Saido TC*. ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis. Acta Neuropathol, 132, 111-126, 2016. 
  15. Kiryu-Seo S*, Kiyama H. The nuclear events guiding successful nerve regeneration. Front Mol Neurosci, 53, 2011.
  16. Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H. Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuro-muscular junctions. J Neurosci, 30, 6954-6962, 2010.
  17. Kiryu-Seo S, Ohno N, Kidd GJ, Komuro H, Trapp BD. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport. J Neurosci, 30, 6658-6666, 2010.
  18. Gamo K, Kiryu-Seo S, Konishi H, Aoki S, Matsushima K, Wada K, Kiyama H.G-protein-coupled receptor screen reveals a role for chemokine receptor CCR5 in suppressing microglial neurotoxicity. J Neurosci. 28, 11980-11988, 2008.
  19. Kiryu-Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K, Kiyama H. Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. J Biol Chem, 283, 6988-96, 2008.
  20. Kiryu-Seo S, Gamo K, Tachibana T, Tanaka, K and Kiyama H. Unique anti-apoptotic activity of EAAC1 in injured motor neurons. EMBO J, 25, 3411-3421, 2006.
  21. Kiryu-Seo S, Hirayama T, Kato R, Kiyama H. Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse. J Neurosci, 25, 1442-1447, 2005.
  22. Nakagomi S, Suzuki Y, Namikawa K, Kiryu-Seo S, Kiyama H. Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. J Neurosci, 23, 5187-5196, 2003.
  23. Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S, Wada K, Kiyama H. Damage Induced Neuronal Endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Proc. Natl. Acad. Sci. USA, 97, 4345-4350, 2000.

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