原著（英文）
1. Kimura,Y., Ito,Y., Shimokata,
K., Nishiyama, Y., and Nagata, I. Temperature-sensitive virus
derived from BHK cells persistently infected with HVJ (Sendai
virus). Journal of Virology 15: 55 - 63 (1975)
2. Ito,Y., Nishiyama,Y., Shimokata,K., Kimura,Y., Nagata,I., Shimizu,K.,
and Kunii,A. Interferon induction in mice by BHK cells persistently
infected with HVJ. Journal of General Virology 27: 93-95
(1975)
3. Ito,Y., Nishiyama,Y., Shimokata,K., Kimura,Y., Nagata,I., and
Kunii,A. Interferon-producing capacity of germfree mice. Infection
and Immunity 13: 332 - 336 (1976)
4. Shimokata,K., Nishiyama,Y., Ito,Y., Kimura,Y., Nagata,I., Iida,M.,
and Sobue,I. Pathogenesis of Sendai virus infection in the central
nervous system of mice. Infection and Immunity 13: 1497
- 1502 (1976)
5. Nishiyama,Y., Ito,Y., Shimokata,K., Kimura,Y., and Nagata,I. Polykaryocyte
formation induced by VSV in mouse L cells. Journal of General
Virology 32: 73 - 83 (1976)
6. Nishiyama,Y., Ito,Y., Shimokata,K., Kimura,Y., and Nagata,I. Relationship
between establishment of persistent infection of HVJ and the properties
of the virus. Journal of General Virology 32: 85 - 96 (1976)
7. Ito Y., Nishiyama,Y., Shimokata,K., Kimura,Y., Nagata,I., and
Kunii,A. Interferon production in L cells persistently infected
with HVJ. Virology 71: 463 - 470 (1976)
8. Kimura,Y., Norrby,E., Nagata,I., Ito,Y., Shimokata,K., and
Nishiyama,Y. Homologous interference induced by a temperature
sensitive mutant derived from HVJ(Sendai virus) carrier culture.
Journal of General Virology 33: 333 - 343 (1976)
9. Ito,Y., Nishiyama,Y., Shimokata,K., Kimura,Y., Nagata,I., and
Kunii,A. The effect of cytochalasin and colchicine on interferon
production. Journal of General Virology 33: 1 - 5 (1976)
10. Shimokata,K., Nishiyama,Y., Ito,Y., Kimura,Y., and Nagata,I. An
affinity of Sendai virus to the inner ear of mice. Infection
and Immunity 15: 706 - 708 (1977)
11. Nishiyama,Y. Studies of L cells persistently infected with
VSV : Factors involved in the regulation of persistent infection.
Journal of General Virology 35:265 - 279 (1977)
12. Nishiyama,Y., Ito,Y., Shimokata,K., Nagata,I., Kurachi,N.,
and Sugiura,Y. Comparative studies on cytopathic effects induced
by vesicular stomatitis virus in two cell types. Microbiology
and Immunology 21: 693 - 702(1977)
13. Nishiyama,Y., Ito,Y., and Shimokata,K. Properties of
the viruses selected during persistent infection of L cells with
VSV. Journal of General Virology 40: 0481 - 484 (1978)
14. Ito,Y., Nishiyama,Y., Shimokata,K., Nagata,I., Takeyama,H.,
and Kunii,A. The mechanism of interferon induction in mouse spleen
cells stimulated with HVJ. Virology 88: 128 -137 (1978)
15. Ito,Y., Nishiyama,Y., Shimokata,K., Takeyama,H., and Kunii,A.
Active component of HVJ(Sendai virus) for interferon induction
in mice. Nature 274: 801 - 802 (1978)
16. Ito,Y.,Nishiyama,Y., Shimokata,K., Takeyama,H., and Kunii,A.
Temperature sensitivity of interferon susceptibility in L cells
persistently infected with HVJ. Virology 89: 333 - 345
(1978)
17. Ito,Y., Nishiyama,Y., Shimokata,K., Takeyama,H.,and Kunii,A.
Suppression of interferon production in mouse spleen cells by
cytocalasin D. Journal of General Virology 41: 129 - 134
(1978)
18. Nishiyama,Y., Ito,Y., Shimokata,K., and Kimura,Y. The induction
of interferon by vesicular stomatitis virus in mouse L cells.
Microbiology and Immunology 23: 233 - 247 (1979)
19. Ito,Y., Nishiyama,Y., Shimokata,K., Nagata,I., and Kunii,A.
Interferon susceptibility of various cell lines persistently infected
with HVJ. Journal of General Virology 43: 103 - 110 (1979)
20. Shimokata,K., Nishiyama,Y., Ito,Y., Kimura,Y., Takano,M.,
Nagata,I., and Kunii,A. Examination of latent infection in germfree
mice for some murine viruses. Experimental Animals 28:
57 - 60 (1979)
21. Ito,Y., Nishiyama,Y., Shimokata,K., Takeyama,H., and Kunii,A.
Immune interferon produced in vitro as a quantitative indicator
of cell-mediated immunity. Microbiology and Immunology
23: 1169 -1177 (1979)
22. Iinuma,M., Nishiyama,Y., Hamaguchi,M., Yoshida,T., Maeno,K.,
and Matsumoto,T. Isolation and characterization of heat-resistant(HR)
mutant of Newcastle disease virus. Microbiology and Immunology
23; 1179 -1188 (1979)
23. Nishiyama, Y. and Rapp, F. Anticellular effects of 9-(2-hytroxymethyl)
guanine against herpes simplex virus-transformed cells. Journal
of General Virology 45: 227 - 230 (1979)
24. Nishiyama, Y. and Rapp, F. Regulation of persistent infection
with herpes simplex virus in vitro by hydrocortisone. Journal
of Virology 31: 841 - 844 (1979)
25. Shimokata,K., Ito,Y., Nishiyama,Y., and Kimura,Y. Influence
of tripsin on the infectivity and biological properties of parainfluenza
type 2(croup-associated) virus in Vero cells. Journal of General
Virology 48: 407 - 410 (1980)
26. Nishiyama,Y., and Rapp,F. Enhanced survival of ultraviolet-irradiated
herpes simplex virus in human cytomegalovirus-infected cells.
Virology 100: 189 - 193 (1980)
27. Rapp,F., and Nishiyama,Y. Inhibition of herpes simplex virus
type 2-induced biochemical transformation by interferon. Journal
of Virology 33: 543 - 546 (1980)
28. Nishiyama,Y., and Rapp,F. Latency in vitro using irradiated
herpes simplex virus. Journal of General Virology 52: 113
- 119 (1981)
29. Nishiyama,Y., and Rapp,F. Enhanced capacity of DNA repair
in human cytomegalovirus infected cells. Journal of Virology
38: 164 - 172 (1981)
30. Nishiyama,Y., and Rapp,F. Repair replication of viral and
cellular DNA in herpes simplex virus type 2-infected human embryonic
and xeroderma pigmentosum fibroblasts. Virology 110:0466
- 475 (1981)
31. Shimokata,K., Ito,Y., Nishiyama,Y., and Kimura,Y. Plaque formation
by human-origin parainfluenza type 2 virus in established cell
lines. Archives of Virology 67: 355 - 360 (1981)
32. Shibata,M., Maeno,K., Tsurumi,T., Aoki,H., Nishiyama,Y., Ito,Y.,
Isomura,S., and Suzuki,S. Role of viral glycoproteins in haemolysis
by influenza B virus. Journal of General Virology 59: 183
- 186 (1982)
33. Nishiyama,Y., Maeno,K., and Yoshida,S., Correlation of increased
nuclease activity with enhanced virus reactivation. Experimental
Cell Research 138: 485 - 489 (1982)
34. Nishiyama,Y., Aoki,H., Tsurumi,T., and Maeno,K. Lack of detectable
DNA damage in cells productively infected with human cytomegalovirus.
Microbiolgy and Immunology 26: 435 - 439 (1982)
35. Morita,T.,Tsutsui,Y., Nishiyama,Y., Nakamura,H., and Yoshida,S.
Effect of DNA polymerase inhibitors on replicative and repair
DNA synthesis in ultraviolet-irradiated HeLa cells. International
Journal of Radiation Biology 42: 471 - 480 (1982)
36. Nishiyama,Y., Maeno,K., and Yoshida,S. Characterization of
human cytomegalovirus-induced DNA polymerase and the associated
3'-to-5' exonuclease. Virology 124: 221 - 231 (1983)
37. Shibata,M., Aoki,H., Tsurumi,T., Nishiyama,Y., Sugiura,Y.,
Suzuki,S., and Maeno,K. Mechanism of uncoating of influenza B
virus in MDCK cells: Action of chloroquine. Journal of General
Virology 64: 1149 - 1156 (1983)
38. Nishiyama,Y., Tsutsui,Y.,Tsurumi,T., Aoki,H., Ito,Y., and
Maeno,K. Heat-Induced polypeptides in human embryonic fibroblasts.
Experientia 39: 412 - 413 (1983)
39. Tsurumi,T., Aoki,H., Nishiyama,Y., Shibata,M., Maeno,K., and
Fujioka,H. Effect of high salt treatment on influenza B viral
protein synthesis in MDCK cells. Microbiology and Immunology
27: 519 - 529 (1983)
40. Tsurumi,T., Nishiyama,Y., Aoki,H., Shibata,M., Maeno,K., and
Fujioka,H. Removal of HA1 subunit of HA monomer from influenza
virions. Microbiology and Immunology 27: 717 - 721 (1983)
41. Tsutsui,Y., Nishiyama,Y., Yoshida,S., Maeno,K., and Hoshino,M.
Role of the nuclear matrix in the growth of herpes simplex virus
type 2. Archives of Virology 77: 27 - 38 (1983)
42. Nishiyama,Y., Tsurumi,T., Aoki,H., and Maeno,K. Identification
of DNA polymerase(s) involved in the repair of viral and cellular
DNA in herpes simplex virus type 2-infected cells. Virology
129: 524 - 528 (1983)
43. Nishiyama,Y., Yoshida,S., and Maeno,K. Involvement of DNA
polymerase _ in host cell reactivation of UV-irradiated herpes
simplex virus. Journal of Virology 49: 598 - 600 (1984)
44. Takeura,S., Aoki,H., Tsurumi,T., Nishiyama,Y., Fujioka,H.,
Yoshii,S., and Maeno,K. Abortive infection of L cells by influenza
B virus: Defect in bud formation. Microbiology and Immunology
28: 427 - 437 (1984)
45. Ito,Y., Nishiyama,Y., Shimokata,K., and Maeno,K. Effects of
exogeneous interferon on L cells persistently infected with Sendai
virus. Archives of Virology 80: 33 - 45 (1984)
46. Nishiyama,Y., Suzuki,S., Yamauchi,M., Maeno,K., and Yoshida,S.
Characterization of an aphidicolin-resistant mutant of herpes
simplex virus type 2 which induces an altered viral DNA polymerase
Virology 135: 87 - 96 (1984)
47. Aoki,H., Nishiyama,Y., Tsurumi,T., Sibata,M., Ito.Y., Seo,H.,
Yoshii,S., and Maeno.K. Mechanism of interference between influenza
A/WSN and B/Kanagawa viruses. Journal of General Virology 65:
1385 - 1393 (1984)
48. Nishiyama,Y., Yoshida,S., Tsurumi,T., Yamamoto,N., and Maeno,K.
Drug-resistant mutants of herpes simplex virus type 2 with a mutator
or antimutator phenotype. Microbiology and Immunology 29:
377 - 381 (1985)
49. Yamauchi,M., Nishiyama,Y., Fujioka,H., Isomura,S.,and Maeno,K.
On the intracellular transport and the nuclear association of
human cytomegalovirus structural proteins. Journal of General
Virology 66: 675-684 (1985)
50. Suzuki,S., Saneyoshi,M., Nakayama,C., Nishiyama,Y., and Yoshida,S.
Mechanism of selective inhibition of human cytomegalovirus replication
by 1-_-D-arabinofuranosyl-5-fluorouracil. Antimicrobial Agents
and Chemotherapy 28: 326 - 330 (1985)
51. Suzuki,S., Saneyoshi,M., Nakayama,C., and Nishiyama,Y. Selective
inhibition of human cytomegalovirus replication by 1-_-D-arabinofuranosyl-fluorouracil.
Herpesviruses and Virus Chemotherapy (ed. R. Kono, Elsevier)
52. Tsurumi,T., Maeno,K., and Nishiyama,Y. Molecular cloning of
herpes simplex virus type 2 DNA Journal of Biochemistry
99: 981 - 984 (1986)
53. Nishiyama,Y., Fujioka,H., Tsurumi,T., Maeno,K.,Yoshida,S.,
and Shimokata,K. Effects of the epipodophillotoxin VP-16-213 on
herpes simplex virus type 2 replication. Journal of General
Virology 68: 913 - 918 (1987)
54. Tsurumi.T., Maeno,K., and Nishiyama,Y. A single-base change
within the DNA polymerase locus of herpes simplex virus type 2
can confer resistance to aphidicolin Journal of Virology
61: 388 - 394 (1987)
55. Yamamoto,N., and Shimokata,K., Maeno,K., and Nishiyama,Y.
Effect of recombinant human interferon against human cytomegalovirus.
Archives of Virology 94: 323 - 329 (1987)
56. Tsurumi,T., Maeno,K., and Nishiyama,Y. Nucleotide sequence
of the DNA polymerase gene of herpes simplex virus type 2 and
the comparison with HSV-1 counterpart. Gene 52: 129 - 137
(1987)
57. Abbotts,J., Nishiyama,Y., Yoshida,S., and Loeb,L.A. On the
fidelity of DNA replication: Herpes DNA polymerase and its associated
exonuclease. Nucleic Acids Research 15: 1185 - 1198 (1987)
58. Yamamoto,N., Tsurumi,T., Fukushima,M., Maeno,K., and Nishiyama,Y.
Mechanism of inhibition of herpes simplex virus replication by
_7-prostaglandin A1 and _12-prostaglandin J2. Biochemical and
Biophysical Research Communications 146: 1425 - 1431(1987)
59. Rahman,M.M., Yamamoto,N., Morishima,T., Maeno,K.,and Nishiyama,Y.
Inhibition of herpes simplex virus type 2 replecation in vitro
by 1-N-pentadecanoyl-3"-N-trifluoroacetyl kanamycin A. Antiviral
Research 9: 11 - 22 (1988)
60. Nishiyama,Y., Yamamoto,N., Takahashi,K., and Shimada,N. Selective
inhibition of human cytomegalovirus replication by a novel nucleoside,
Oxetanocin G. Antimicrobial Agents and Chemotherapy 32:
1053 - 1056 (1988)
61. Takagi,E., Kawatsu,H., Shimokata,K., Nishiyama,Y., Kojima,K.,
and Yoshida,S. Establishment and characterization of resistant
cells to Etoposide(VP16) from a mouse breast cancer cells line,FM3A.
Japanese Journal of Cancer Research(Gann) 79: 938 - 944
(1988)
62. Fujioka,H., Nishiyama,Y., Furukawa,H., and Kumada,N. In vitro
and in vivo activities of atalaphillinine and related acridone
alkaloids against rodent malaria. Antimicrobial Agents and
Chemotherapy 33: 6 - 9 (1989)
63. Yamamoto,N., Rahman,M., Fukushima,M., Maeno,K., and Nishiyama,Y.
Involvement of prostaglandin-induced protein in the inhibition
of herpes simplex virus replication. Biochemical and Biophysical
Research Communications 158: 189 - 194 (1989)
64. Nishiyama,Y., Yamamoto,N., Yamada,Y., Fujioka,H., Shimada,N.,
and Takahashi,K. Efficacy of oxetanocin G against herpes simplex
virus type 2 and murine cytomegalovirus infection in mice. Journal
of Antibiotics 42: 1308 - 1311 (1989)
65. Yamamoto,N., Furukawa,H., Ito,Y., Yoshida,S., Maeno,K., and
Nishiyama,Y. Anti-herpesvirus activity of citrucinine-1, a new
acridone alkaloid and related compounds. Antiviral Research
12: 21 - 36 (1989)
66. Nishiyama,Y., Yamamoto,N., Yamada,Y., Daikoku,T., Ichikawa,Y.,
and Takahashi,K. Anti-herpesvirus activity of carbocyclic oxetanocin
G in vitro. Journal of Antibiotics 42: 1854 - 1859 (1989)
67. Yamada,Y., Yamamoto,N., Maeno,K., and Nishiyama,Y. Role of
DNA topoisomerase I in the replication of herpes simplex virus
type 2. Archives of Virology 110: 121 - 127 (1990)
68. Nawa,A., Nishiyama,Y., Yamamoto,N., Maeno,K., Goto,S., and
Tomoda,Y. Selective supperession of human papilloma virus type
18 mRNA level in HeLa cells by interferon. Biochemical and
Biophysical Research Communications 170: 793 - 799 (1990)
69. Fujioka,H., Kato,N., Fujita,K., Fujimura,K., and Nishiyama,Y.
Activities of new acridone alkaloid derivatives against Plasmodium
yoelii in vitro. Drug Research 40: 1026 - 1029 (1990)
70. Kitamura,K., Yamada,K., Kuzushima,K., Morishima,T., Yamamoto,N.,
Nishiyama,Y., Ohya,K., and Yamaguchi,H. Human monoclonal antibodies
to human cytomegalovirus derived from peripheral blood lymphocytes
of healthy adults. Journal of Medical Virology 32: 60 -
66 (1990)
71. Kimura,H., Shibata,M., Kuzushima,K., Nishikawa,K., Nishiyama,Y.,
and Morishima,T. Detection and direct typing of herpes simplex
virus by polymerase chain reaction(PCR). Medical Microbiology
and Immunology 179: 177 - 184 (1990)
72. Yamamoto,N., Yamada,Y., Daikoku,T., Nishiyama,Y., Tsutsui,Y.,
Shimada,N., and Takahashi, K. Antiviral effect of oxetanocin G
against guinea pig cytomegalovirus infection in vitro and in vivo.Journal
of Antibiotics 43: 1573 - 1578 (1990)
73. Fukushima,M., Kato,T., Narumia,S., Mizushima,Y., Sasaki,H.,
Terashima,Y., Nishiyama,Y., and Santro,M.G. Prostaglandin A and
J: Antitumor and antiviral prostaglandins. Advances in Prostaglandin,
Thromboxane and Leukotriene Research, Vol 16 (eds. Samuelsson,
B., Wong, P.Y.K., and Sun,F.F., Raven Press)
74. Queener,S.F., Fujioka,H., Nishiyama,Y., Furukawa,H., Batlett,M.S.,
and Smith,J.W. In vitro activity of acridone alkaloids against
Pneumocystis carinii. Antimicrobial Agents and Chemotherapy
35: 377 - 379 (1991)
75. Yamada,Y., Shimokata,K., Yamada,Y., Yamamoto,N., Goshima,F.,
and Nishiyama,Y. A kanamycin derivative inhibits in vitro and
in vivo replication of influenza A virus. Antiviral Research
15: 171 - 182 (1991)
76. Daikoku,T., Yamamoto.N., Maeno,K., and Nishiyama,Y. Role of
viral ribonucleotide reductase in the increase of dTTP pool size
in herpes simplex virus-infected cells. Journal of General
Virology 72: 1441 - 1444 (1991)
77. Daikoku,T., Yamamoto,N., Saito,S., Kitagawa,M., Shimada,N.,
and Nishiyama,Y. Mechanism of inhibition of human cytomegalovirus
replication by oxetanocin G.Biochemical and Biophysical Research
Communications 176: 805 - 812 (1991)
78. Nishiyama,Y., Kimura,H., and Daikoku,T. Complementary lethal
invasion of the central nervous system by nonneuroinvasive herpes
simplex virus types 1 and 2. Journal of Virology 65: 4520
- 4524 (1991)
79. Yamada,Y., Yamamoto,N., Daikoku,T., and Nishiyama,Y. Susceptibility
of a herpes simplex virus ribonucleotide reductase null mutant
to deoxyribonucleosides and antiviral nucleoside analogs.
Microbiology and Immunology 35: 681 - 686 (1991)
80. Yamada,Y., Kimura,H., Morishima,T., Daikoku,T., Maeno,K.,
and Nishiyama,Y. The pathogenicity of ribonucleotide reductase
null mutants of herpes simplex virus type 1 in mice. Journal
of Infectious Disease 164 :1091 - 1097 (1991)
81. Nawa,A., Nishiyama,Y., Kikkawa,F., Kurauchi,O., Goto,S., Suganuma,N.,
Mizutani,S., and Tomoda,Y. Testing histologically negative lymph
nodes for papillomavirus when evaluating metastasis in cervical
cancer. Lancet 339: 1231 (1992)
82. Nishiyama,Y., Yamada,Y., Kurachi,R., and Daikoku,T. Construction
of a US3 lacZ insertion mutant of herpes simplex virus type 2
and characterization of its phenotype in vitro and in vivo.
Virology 190: 256 - 268 (1992)
83. Yamashita,Y., Shimokata,K., and Nishiyama,Y. On the association
of human _2 microglobulin with cell culture-grown human cytomegalovirus.
Virology 190: 449 - 453 (1992)
84. Ikeda,T., Shimokata., Daikoku.T., Fukatsu,T., Tsutsui,Y.,
and Nishiyama,Y. Pathogenesis of cytomegalovirus-associated pneumonitis
in ICR mice: Possible involvement of superoxide radicals. Archives
of Virology 127: 11 - 24 (1992)
85. Kato,N., Fujita,M., Fujimura,K., Kawashima,Y., and Nishiyama,Y.
Synthesis of acridone alkaloid citrusinine-1 and its derivatives.
Chemical Pharmacological Bulletin 41: 445 - 452 (1993)
86. Yamashita,Y., Shimokato,K., Mizuno,S., Yamaguchi,H., and Nishiyama,Y.
Down-regulation of the surface expression of class 1 MHC antigens
by human cytomegalovirus. Virology 193: 727 - 736 (1993)
87. Nawa,A., Nishiyama,Y., Kikkawa,F., Kawai,M., Mano,H., Goto,S.,
Suganuma,N., Tomoda,Y., and Nakashima,N. Detection of human papillomaviruses
from histologically normal lymph nodes of Japanese cervical cancer
patients by nested polymerase chain-reaction assay.
International Journal of Cancer 53: 932 - 937 (1993)
88. Nishiyama,Y., Kurachi,R., Daikoku,T., and Umene,K. The US9,10,11,
and 12 genes of herpes simplex virus type 1 are of no importance
for its neurovirulence and latency in mice
Virology 194:419 - 423 (1993)
89. Tsurumi,T., Kobayashi,A., Tamai,K., Daikoku,T., Kurachi,R.,
and Nishiyama,Y. Functional expression and characterization of
the Epstein-Barr virus DNA polymerase catalytic subunit. Journal
of Virology 67: 4651 - 4658 (1993)
90. Masuda,A., Kitagawa,M., Tanaka,A., Saito,S., Shimada,N., Ikeda,R.,
Hoshino,H., Daikoku,T., and Nishiyama,Y. Synthesis and antiviral
antiviral activity of adenosine deaminase-resistant oxtanocin
A derivatives: 2-halogeno-oxetanocin A. Journal of Antibiotics
46: 1034 - 1037 (1993)
91. Kurachi,R., Daikoku,T., Tsurumi,T., Maeno,K., Nishiyama,Y.,
and Kurata,T. The pathogenicity of a US3 protein kinase-deficient
mutant of herpes simplex virus type 2 in mice. Archives of
Virology 133: 259 - 273 (1993)
92. Tsurumi,T., Daikoku,T., Kurachi,R., and Nishiyama,Y. Functional
interaction between Epstein-Barr virus DNA polymerase catalytic
subunit and its accessory subunit in vitro. Journal of Virology
67: 7648 - 7653 (1993)
93. Daikoku,T., Yamashita,Y., Tsurumi,T., Maeno,K., and Nishiyama,Y.
Purification and biochemical characterization of the protein kinase
encoded by the US3 gene of herpes simplex virus type 2.
Virology 197: 685 - 694 (1993)
94. Yamashita,Y., Shimokata,K., Saga,S., Mizuno,S., Tsurumi,T.
and Nishiyama,Y. Rapid degradation of the heavy chain of class
I major histocompatibility antigens in the endoplasmic reticulum
of human cytomegalovirus-infected cells. Journal of Virology
68: 7933-7943 (1994).
95. Daikoku,T., Kurachi,R., Tsurumi,T. and Nishiyama,Y. Identification
of a target protein of US3 protein kinase of herpes simplex virus
type 2. Journal of General Virology 75: 2065-2068 (1994).
96. Tsurumi,T., Daikoku,T. and Nishiyama,Y. Further characterization
of the interaction between Epstein-Barr virus DNA polymerase catalytic
subunit and its accessory subunit with regard to the 3'-to-5'
exonucleotic activity and stability of initiation complex at primer
termini. Journal of Virology 68: 3354 - 3363 (1994).
97. Jiang, Y.-M., Daikoku, T., Yamamoto, M., Morishima, T. and
Nishiyama, Y. Growth and cytopathogenicity of herpes simplex virus
in a macrophage cell line, RAW264: A good indicator of intraperitoneal
pathogenicity. Microbiology and Immunology 39: 905-909
(1995).
98. Daikoku, T., Yamashita, Y., Tsurumi, T. and Nishiyama, Y.
The US3 protein kinase of HSV type 2 is associated with phosphorylation
of the UL12 alkaline nuclease in vitro. Archives of Virology
140: 1637-1644 (1995).
99. Nawa, A., Nishiyama, Y., Kobayashi, T., Wakahara, Y., Okamoto,
T., Kikkawa, F., Suganuma, N., Goto, S., Kuzuya, K. and Tomoda,
Y. Association of HLA-B1*03 with cervical cancer in Japanese women
aged 35 and younger. Cancer 75: 518-521 (1995).
100. Kobayashi, T., Yokoyama, I., Nishiyama, Y., Hayashi, S.,
Uchida, k. and Takagi, H. Strong enhancement of HLA class I surface
expression by incomplete cytomegalovirus particle: Analysis by
dual-color flow cytometry using saponin. Transplantation Proceedings
27: 966-969 (1995).
101. Nishiyama, Y. Herpesvirus genes: Molecular basis of viral
replication and pathogenicity. Nagoya Journal of Medical Science
59: 107 - 119 (1996).
102. Ozaki, N., Sugiura, Y., Yamamoto, M. and Nishiyama, Y. Induction
of Fos protein expression in spinal cord neurons by herpes simplex
virus infections in the mouse. Neuroscience Letters 216:
61 - 64 (1996).
103. Yamashita, Y., Yamada, M., Daikoku, T., Yamada, H., Tadauchi,
A., Tsurumi, T. and Nishiyama, Y. Calnexin associates with the
precursors of glycoprotein B, C, and D of herpes simplex virus
type 1. Virology 225: 216 - 222 (1996).
104. Tsurumi, T., Kobayashi, A., Tamai, K., Yamada, H., Daikoku,
T., Yamashita, Y. and Nishiyama, Y. Epstein-Barr virus single-stranded
DNA-binding protein: Purification, characterization, and action
on DNA synthesis by the viral DNA polymerase. Virology
222: 352 - 364 (1996).
105. Yamashita, Y., Shimokata, K., Mizuno, T., Daikoku, T., Tsurumi,
T. and Nishiyama, Y. Calnexin acts as a molecular chaperone during
the folding of glycoprotein B of human cytomegalovirus. Journal
of Virology 70: 2237-2246 (1996).
106. Yamamoto, M., Kurachi, R., Morishima, T., Kito, J. and Nishiyama,
Y. Immunohistochemical studies on the transneuronal spread of
virulent herpes simplex virus type 2 and its US3 protein kinase-deficient
mutant after ocular inoculation. Microbiology and Immunology
40: 289-294 (1996).
107. Wada, K., Mizuno, S., Ohata, H. and Nishiyama, Y. Immune
response to neutralizing epitope on human cytomegalovirus glycoprotein
B in Japanese: correlation of serologic response with HLA-type.
Microbiology and Immunology 41: 841 - 845 (1997) .
108. Yamada, H., Daikoku, T., Yamashita, Y., Jiang, Y.-M., Tsurumi,
T. and Nishiyama, Y. The product of the US10 gene of herpes simplex
virus type 1 is a capsid/tegument -associated phosphoprotein which
copurifies with the nuclear matrix. Journal of General Virology
78: 2923 - 2931 (1997).
109. Daikoku, T., Shibata, S., Goshima, F., Oshima, S., Tsurumi,
T., Yamada, H., Yamashita, Y. and Nishiyama, Y. Purification and
characterization of the protein kinase encoded by the UL13 gene
of herpes simplex virus type 2. Virology 235: 82 - 93 (1997).
110. Tsurumi, T., Yamada, H., Daikoku, T., Yamashita, Y. and Nishiyama,
Y. Strand displacement associated DNA synthesis catalyzed by the
Epstein-Barr virus DNA polymerase. Biochemical and Biophysical
Research Communications 238: 33 - 38 (1997).
111. Ozaki, N., Sugiura, Y., Yamamoto, N., Yokota, S., Wanaka,
A. and Nishiyama, Y. Apoptosis induced in the spinal cord and
dorsal root ganglion by infection of herpes simplex virus type
2 in the mouse. Neuroscience Letters 228: 99 - 102 (1997).
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182. Mori, I., Goshima, F., Koshizuka, T., Imai, Y., Kohsaka,
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187. Kimura, H., Ito, Y., Futamura, M., Ando, Y., Hara, S., Sobajima,
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194. Kimata, H., Takakuwa, H., Goshima, F., Teshigawara, O., Nakao,
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by living donor liver transplantation. Pediatrics International
46: 730-732 (2004).
201. Nozawa, N, Yamauchi, Y., Ohtsuka, K., Kawaguchi, Y.,
and Nishiyama, Y. Formation of aggresome-like structures in herpes
simplex virus type 2-infected cells and a potential role in virus
assembly. Experimental Cell Research 299: 486-497 (2004).
202. Sugiura, S., Yoshikawa, T., Nishiyama, Y., Morishita, Y.,
Sato, E., Beppu, R., Hattori, T. and Nakashima T. Detection of
herpesvirus DNAs in perilymph obtained from patients with sensorineural
hearing loss by real-time polymerase chain reaction. Laryngoscope
114(12): 2235-2238 (2004).
203. Mori, I., Nishiyama, Y., Yokochi, T. and Kimura, Y. Virus-induced
neuronal apoptosis as pathological and protective responses of
the host. Reviews in Medical Virology 14: 209-216 (2004).
204. Mori, I., Kimura, Y., Naiki, H., Matsubara R., Takeuchi,
T., Yokochi, T., and Nishiyama, Y. Reactivation of HSV-1 in the
brain of patients with familial Alzheimer's disease. Journal
of Medical Virology 73: 605-611 (2004).
205. Nakao, A., Kimata, H., Imai, T., Kimumori, T., Teshigahara,
O., Nagasaka, T , Goshima, F. and Nishiyama, Y. Intratumoral injection
of herpes simplex HF10 in rexurrent breast cancer. Annals of
Oncology 15: 988-989 (2004).
206. Tanaka, M., Kodaira, H., Nishiyama, Y., Sata, T., and Kawaguchi,
Y. Construction of recombinant herpes simplex virus type 1 expressing
green fluorescent protein without loss of any viral genes. Microbes
and Infection 6: 485-493 (2004).
207. Nishimura, H., Yajima, T., Kagimoto, Y., Ohata, M., Watase,
T., Kishihara, K., Goshima, F., Nishiyama, Y. and Yoshikai, Y.
Intraepithelial __ T may bridge a gap between innate and acquired
immunity to herpes simplex virus type 2. Journal of Virology
78: 4927-4930 (2004).
208. Kanamori, M., Watanabe, S., Honma, R., Kuroda, M., Imai,
S., Yamamoto, N., Nishiyama, Y., and Kawaguchi, Y. Epstein-Barr
virus nuclear antigen leader protein induces expression of thymus
and activation-regulated chemokine in B cells. Journal of
Virology 78: 3984-3993 (2004).
209. Niimi, A., Limsirichaikul, S., Yoshoda, S., Iwai, S.,
Masutani, C., Hanaoka, F., Kool, E. T., Nishiyama, Y. and Suzuki,
M. Palm residue mutant in DNA polymerases _ and _ alter DNA replication
fidelity and translesion activity. Molecular and Cellular
Biology 24: 2734-2746 (2004).
210. Mori, I., Yokochi, T., Koide, N., Sugiyama, T., Yoshida,
T., Kimura, Y., Naiki, H., Matsubara, R., Takeuchi, T., and Nishiyama,
Y. PCR search for HSV-1 genome in the brain section of patients
with familal Alzheimer's disease. Journal of Clinical Microbiology
42: 936-937 (2004).
211. Sugiura, S., Goshima, F., Takakuwa, H., Sata, T., Nakashima,
T., and Nishiyama, Y. Treatment of solid sarcomas in immunocometent
mice with novel oncolytic herpes simplex viruses. Otolaryngological
Head and Neck Surgery 130: 470-478 (2004).
212. Asano, S., Yoshikawa, T., Kimura, H., Enomoto, Y., Ohashi,
M., Terasaki, H. and Nishiyama, Y. Monitoring herpesvirus DNA
in three cases of acute retinal necrosis by real-time PCR. Journal
of Clinical Virology 29: 206-209 (2004).
213. Yoshikawa, T., Ihira, M., Akimoto, S., Usui, C., Miyake,
F., Suga, S., Enomoto, Y., Suzuki, R., Nishiyama, Y. and Asano,
Y. Detection of human herpesvirus 7 DNA by loop-mediated isothermal
amplification. Journal of Clinical Microbiology 42: 1348-1352
(2004).
214. Suda, N., Ito, Y., Imai, T., Kikumori, T., Kikuchi, A., Nishiyama,
Y., Yoshida, S., and Suzuki, M. The _ 4 residues of human DNA
topoisomerases II _ function in enzymatic activity and anticancer
drug sensitivity.
Nucleic Acids Research 32: 1767-1773 (2004).
215. Nishiyama, Y. Herpes simplex virus gene products: the accessories
reflect her lifestyle well. Reviews in Medical Virology
14: 33-46. (2004).
216. Teshigahara, O., Goshima, F., Takao,K., Kohno, S., Kimata,
H., Nakao, A., and Nishiyama, Y. Oncolytic viral therapy for breast
cancer with herpes simplex virus type 1 mutant HF10. Journal
of Surgical Oncology 85: 42-47. (2004).
217. Ihira M, Yoshikawa T, Enomoto Y, Akimoto S, Ohashi M, Suga
S, Nishimura N, Ozaki T, Nishiyama Y, Notomi T, Ohta Y, Asano
Y. Rapid diagnosis of human herpesvirus 6 infection by a novel
DNA amplification method, Loop-mediated isothermal amplification.
Journal of Clinical Microbiology 42: 140-145. (2004).
218. Kudoh, A., Daikoku,T.,Sugaya, Y., Isomura, T., Fujita, M.,
Kiyono, T., Nishiyama, Y. and Tsurumi, T. Inhibition of S-phase
cyclin-dependent kinase activity blocks expression of Epstein
Barr virus immediate early and early genes, preventing viral lytic
replication. Journal of Virology 78:104-115. (2004).
219. Nishimura, N., Yoshikawa, T., Ozaki, T., Sun, H., Goshima,
F., Nishiyama, Y., Asano, Y., Kurata, T and Iwasaki, T. In vitro
and in vitro analysis of human herpes ﾐ6 U90 protein expression.
Journal of Medical Virology, 75: 86-92 (2005).
220. Yamamoto, K., Yoshikawa, T., Okamoto, S., Yamaki, K., Shimokata,
K. and Nishiyama, Y. HHV-6 and 7 DNA loads in lung tissues collected
from patients with interstitial pneumonia. Journal of Medical
Virology , 75: 70-75 (2005).
221. Nagai, H., Wada K., Morishita, T., Utsumi, M., Nishiyama,
Y. and Kaneda, T. New estimation method for highly sensitive quantitation
of human immunodeficiency virus type 1 DNA and its application.
Journal of Virological Methods 124: 157-165 (2005).
222. Enomoto, Y., Yoshikawa, T., Ihira, M., Akimoto, S., Miyake
F., Usui, C., Suga, S., Suzuki, K., Kawana T., Nishiyama, Y. and
Asano, Y. Rapid Diagnosis of herpes simplex virus infection by
a loop-mediated isothermal amplification method. Journal of
Clinical Microbiology 43: 951-955 (2005).
223. Koshizuka, T., Kawaguchi, Y. and Nishiyama, Y. Herpes simplex
virus type 2 membrane protein UL56 associates with the kinesin
motor protein KIFIA. Journal of General Virology 86: 527-533
(2005).
224. Mori, I., Nishiyama, Y., Yokochi, T. and Kimura, Y. Olfactory
transmission of neurotropic viruses.
Journal of NeuroVirology 11:129-37 (2005).
225. Kudoh, A., Fujita, M., Zhan, L., Shirata, N., Daikoku, T.,
Sugaya, Y., Isomura, H., Nishiyama, Y. and Turumi, T. Epstein-Barr
virus lytic replication elicits ATM checkpoint signal transduction
while providing an S-phase-like cellular environment. Journal
of Biological Chemistry 280: 8156-8163 (2005).
226. Mori, I., Goshima, F., Ito, H., Koide, N., Yoshida, T., Yokochi,
T., Kimura, Y. and Nishiyama, Y. The vomeronasal chemosensory
system as a potent route of neuroinvasion by herpes simplex virus.
Virology 334: 51-58 (2005).
227. Mori, I., Koshizuka, T., Goshima, F., Ito, H., Koide, N.,
Yoshida, T., Yokochi, T., Kimura, Y. and Nishiyama Y. Herpes
simplex virus US11 shows intercellular trafficking activity in
the mouse brain. Molecular Brain Research 136: 158-163
(2005).
228. Nozawa, N., Kawaguchi, Y., Tanaka, M., Kato, A., Kato, A.,
Kimura, H. and Nishiyama, Y. Herpes simplex virus type 1 UL51
protein is involved in maturation and egress of virus particles.
Journal of Virology 79: 6947-6956 (2005).
229. Kato, A., Yamamoto, M., Ohno, T., Kodaira, H., Nishiyama,
Y. and Kawaguchi, Y. Identification of proteins phosphorylated
directly by the US3 protein kinase encoded by herpes simplex virus
1. Journal of Virology 79 :9325-31 (2005).
230. Shaku, F., Matsuda, G., Furuya, R., Kamagata, C., Igarashi,
M., Tanaka, M., Kanamori, M., Nishiyama, Y., Yamamoto, N. and
Kawaguchi, Y. Development of a monoclonal antibody against Epstein-Barr
virus nuclear anti gen leader protein (EBNA-LP) that can detect
EBNA-LP expressed in P3HR1 cells. Microbiology and Immunology
49: 477-483 (2005).
231. Matsuzaki, A., Yamauchi, Y., Kato, A., Goshima, F., Kawaguchi,
Y., Yoshikawa, T. and Nishiyama, Y. The US3 protein kinase of
herpes simplex virus type 2 is required for the stability of the
UL46-encoded tegument protein and its association with virus particles. Journal
of General Virology 86: 1979-1985 (2005).
232. Mori, I., Liu, B., Goshima, F., Ito, H., Koide, N., Yoshida,
T., Yokochi, T., Kimura Y. and Nishiyama, Y. HF10, an attenuated
herpes simplex virus (HSV) type 1 clone, lacks neuroinvasiveness
and protects mice against lethal challenge with HSV types 1 and
2. Microbes and Infection 26; [Epub ahead of print] (2005).
233. Tanaka, M., Nishiyama, Y., Sata, T. and Kawaguchi , Y. The
role of protein kinase activity expressed by the UL13 gene of
herpes simplex virus 1: the activity is not essential for optimal
expression of ICP0 and UL41. Virology 341: .301-312 (2005).
234. Mori, I., Goshima, F., Mizuno, T., Imai, Y., Kohsaka, S.,
Ito, H., Koide, N., Yoshida, T., Kimura, Y., Yokochi, T. and Nishiyama,
Y. Axonal injury in experimental herpes simplex encephalitis. Brain
Research 1057: 186-190 (2005).
235. Mori I, Nishiyama Y. Herpes simplex virus and varicella-zoster
virus: why do these human alphaherpesviruses behave so differently
from one another? Reviews in Medical Virology 15:393-406
(2005).
236. Kohno, S., Luo, C., Goshima, F., Nishiyama, Y., Sata, T.
and Ono, Y. Herpes simplex virus type 1 mutant HF10 oncolytic
virutherapy for bladder cancer. Urology 66: 1116-1121 (2005).
237. Koshizuka, T., Kawaguchi, Y., Goshima, F., Mori, I. and Nishiyama,
Y. Association of two membrane proteins encoded by herpes simplex
virus type2, UL11 and UL56. Virus Genes 32, 157-167 (2006).
238. Kato, A., Yamamoto, M., Ohno, T., Tanaka, M., Sata, T., Nishiyama,Y.,
and Kawaguchi, Y. Herpes simplex virus 1-encoded protein kinase
UL13 phosphorylates the viral US3 protein kinase and regulates
nuclear localization of viral envelopment factors UL34 and UL31.
Journal of Virology, 80:1476-1486 (2006).
239. Asai, R., Kato, A., Kato, K., Kanamori-Koyama, M., Sugimoto,
K., Sairenji, T., Nishiyama, Y. and Kawaguchi, Y. Epstein-barr
virus protein kinase BGLF4 is a virion tegument protein that dissociates
from virions in a phosphorylation dependent process and phosphorylates
the viral innediate-early protein BZLF1. Journal of Virology
80: 5125-5134 (2006).
240. Shibata, Y., Hoshino, Y., Hara, S., Yagasaki, H., Kojima,
S., Nishiyama, Y., Morishima, t., and Kimura, H. Clonality analysis
by sequence variation of the latent membrane protein 1 gene in
patients with chronic active Epstein-Barr virus infection. Journal
of Medical Virology 78:770-779 (2006).
241.Iwata S, Shibata Y, Kawada J, Hara S, Nishiyama Y, Morishima
T, Ihira M, Yoshikawa T, Asano Y, Kimura H. Rapid detection of
Epstein-Barr virus DNA by loop-mediated isothermal amplification
method. J Clin Virol.37: 128-133 (2006).
242.Zhang L, Daikoku T, Ohtake K, Ohtsuka J, Nawa A, Kudoh A,
Iwahori S, Isomura H, Nishiyama Y, Tsurumi T.Establishment of
a novel foreign gene delivery system combining an HSV amplicon
with an attenuated replication-competent virus, HSV-1 HF10. J
Virol Methods 137:177-83 (2006).
243.Kimata, H., Imai, T., Kikumori, T., Teshigawara, O., Nagasaka,
T., Goshima, F., Nishiyama, Y and Nakao, A.Pilot study of oncolytic
viral therapy using mutant herpes simplex virus HF10 against recurrent
metastatic breast cancer.Annals of Surgical Oncology 13:
1078-1084 (2006).
244.Fujimoto, Y., Mizuno, T., Sugiura, S., Goshima, F., Kohno,
S., Nakashima, T. and Nishiyama, Y.Intratumoral injection of herpes
simplex virus HF10 in recurrent head and neck squamous cell carcinoma.Acta
Oto-Laryngologia 126: 1115-1117 (2006).
245.Mori, I., Goshima, F., Watanabe, D., Ito, H., Koide, N., Yoshida,
T., Liu, B., Kimura, Y., Yokochi, T. and Nishiyama, Y.Herpes simplex
virus US3 protein kinase regulates virus-induced apoptosis in
olfactory and vomeronasal chemosensory neurons in vivo.Microbes
and infection 8:1806-1812 (2006).
246.Mori, I. and Nishiyama, Y. Accessory genes define the relationship
between the herpes simplex virus and its host.Microbes and
Infection 8: 2556-2562 (2006).
247.Ushijima Y, Luo C, Goshima F, Yamauchi Y, Kimura H, Nishiyama
Y.Determination and analysis of the DNA sequence of highly attenuated
herpes simplex virus type 1 mutant HF10, a potential oncolytic
virus.Microbes and Infection 9:
142-149 (2007).
248.Tanino T, Nawa A, Kondo, E, Kikkawa F, Daikoku T, Tsurumi
T, Luo C, Nishiyama Y, Takayanagi Y, Nishimori K, Miki Y and Iwaki
M. Paclitaxel-2ﾕ-ethylcarbonate prodrug can overcome P-glycoprotein-mediated
multidrug resistance to increase drug cytotoxicity. Pharmaceertical
Research(PHARM RES) 24: 555-565 (2007).
249.Mori, I. and Nishiyama, Y. Replication-competent herpes simplex
virus: a novel and promising modality for cancer therapy. Current
Topics in Virology 5: 21-30
(2006).
250.Luo, C., Nawa, A., Yamauchi, Y., Kohno, S., Ushijima, Y.,
Goshima, F. and Nishiyama, Y.Intercellular trafficking and cytotoxicity
of recombinant HSV-1 thymidine kinase fused with HSV-2 US11 RXP
repeat peptide. Virus Genes 34:
263-272 (2007).
251.Koshizuka, T., Kawaguchi,
Y., Nozawa, N., Mori, I. and Nishiyama, Y. Herpes simplex virus
protein UL11 but not UL51 is associated with lipid rafts.Virus
Genes, 35: 571-575 (2007).
252.Kohno, S., Luo, C., Nawa, A., Fujimoto, Y., Waranabe, D.,
Goshima, F., Tsurumi, T. and Nishiyama, Y. Oncolytic Virotherapy
with an HSV amplicon vector expressing granulocyte-macrophage
colony-stimulating factor using the replication-competent HSV
type I mutant HF10 as a helperCancer Gene Therapy, 14:
918-926 (2007).
253.Shimoyama, S., Goshima, F., Teshigahara, O., Kasuya, H., Kodera,
Y., Nakao, A. and Nishiyama, Y. Enhanced efficacy of herpes simplex
virus mutant HF10 combined with paclitaxel in peritoneal cancer
dissemination models. Hepato-Gastroenterology, 54: 1038-1042
(2007).
254.Wada, K., Kubota, N., Ito, Y., Yagasaki, H., Kato, K., Yoshikawa,
T., Ono, Y., Ando, H., Fujimoto, Y., Kiuchi, T., Kojima, S., Nishiyama,
Y. and Kimura H. Simultaneous quantification of Epstein-Barr virus,
Cytomegalovirus, and human Herpesvirus 6 DNA in transplant recipients
by multiplex real-time PCR assay.Journal of Clinical Microbiology
45: 1426-1432 (2007).
255.Kasuya, H.,Nishiyama, Y., Nomoto, S., Goshima, F., Takeda,
S., Watanabe, I., Nomura, N., Shikano, T., Fujii, T., Kanazumi,
N. and Nakao, A. Suitability of a US3-inactivated HSV mutant(L1BR1)
as an oncolytic-virus for pancreatic cancer therpay. Cancer
Gene Therapy 14: 533-542 (2007).
256.Nakao, A., Takeda, S., Shimoyama, S., Kasuya, H., Kimata,
H., Teshigahara, O., Sawaki, M., Kikumori, T., Kodera, Y., Nagasaka,
T., Goshima, F., Nishiyama, Y. and Imai, T. Clinical experiment
of mutant herpes simplex virus HF10 therapy for cancer. Curr
Cancer Drug Targets 7: 169-174 (2007).
257.Hattori J, Okumura N, Yamazaki Y, Uchiyama M, Hamaguchi M,
Nishiyama Y, Kaneda T. Beneficial Effect of GB Virus C Co-Infection
in Human Immunodeficiency Virus Type 1-Infected Individuals. Microbiology
and Immunology 51(2): 193-200 (2007).
258.Luo, C., Mori, I., Goshima, F., Ushijima, Y., Nawa, A., Kimura,
H., Nishiyama, Y.
Replication-competent, oncolytic herpes simplex virus type 1 mutants
induce a bystander effect following ganciclovir treatment.Journal
of Gene Medicine, 9: 875-883(2007).
259.Nawa, A., Tanino, T., Luo, C., Iwaki, M., Kajiyama, H., Shibata,
K., Ino, K., Nishiyama, Y. and Kikkawa, F.Gene directed enzyme
prodrug therapy for ovarian cancer. ﾐ Could GDPET become a promising treatment
against ovarian cancer?Anti-Cancer Agents in Medical Chemisyry,
8：232-239 (2008).
260.Kagimoto, T., Yamada, H., Ishikawa, T., Maeda, N., Goshima,
F., Nishiyama, Y., Furue, M., Yoshikai, Y. A regulatory role of
interleukin 15 in wound healing and mucosal in1. Journal of
Leukocyte Biology, 83: 165-172 (2008).
261.Kubota, N., Wada, K., Ito, Y., Shimoyama, Y., Nakamura, S.,
Nishiyama, Y., and Kimura, H. One-step multiplex real-time PCR
assay to analyse the latency patterns of Epstein-Barr virus infection.
Journal of Virological Methods, 147: 26-36 (2008).
262.Watanabe, D., Goshima, F., Mori, I., Tanada, Y., Matsumoto,
Y., Nishiyama, Y. Oncolytic viral therapy for malignant melanoma
with herpes simplex virus type 1 mutant HF10. Journal of Dermatological
Science 50: 185-196 (2008).
263.Yamauchi Y, Kiriyama K, Kubota N, Kimura H, Usukura J, Nishiyama
Y. The UL14 Tegument Protein of Herpes Simplex Virus Type 1 (HSV-1)
is Required for Efficient Nuclear Transport of the Alpha Transinducing
Factor VP16 and Viral Capsids. Journal of Virology, 82:
1094-1106 (2008).
264.Gotoh K, Ito Y, Shibata-Watanabe Y, Kawada J, Takahashi Y,
Yagasaki H, Kojima S, Nishiyama Y, Kimura H. Clinical and virologic
characteristics of 15 patients with chronic active EpsteinﾐBarr
virus infection treated with hematopoietic stem cell transplantation
Clinical Infectious Disease, 46: 1525-1534 (2008).
265.Ito Y, Shibata-Watanabe Y, Ushijima Y, Kawada J, Nishiyama
Y, Kojima S, Kimura H. Oligonucleotide Microarray Analysis of
Gene Expression Profiles followed by a Real-time RT-PCR Assay
in Chronic Active Epstein-Barr Virus Infection. Journal of
Infectious Disease, 197: 663-666 (2008).
266.Kamakura, M., Nawa, A., Ushijima, Y., Goshima, F., Kawaguchi,
Y., Kikkawa, F., Nishiyama, Y. Microarray analysis of transcriptional
responses to infection by herpes simplex virus types 1 and 2 and
their US3-deficient mutants Microbes and Infection 10:
405-413 (2008).
267.Kimura, H. and Nishiyama, Y. Measles Outbreak in Adolescent.JMA
Journal ,in press.
268.Ushijima Y, Koshizuka T, Goshima F, Kimura H, Nishiyama Y.
Herpes Simplex Virus Type 2 UL56 Interacts with the Ubiquitin
Ligase Nedd4 and Increases its Ubiquitination. Journal of Virology
82: 5220-5233 (2008).
269.Yamauchi, Y., Kiriyama, K., Kimura, H. and Nishiyama, Y.
Herpes Simplex Virus Induces Extensive Modification and Dynamic
Relocalisation of the Nuclear Mitotic Apparatus Protein (NuMA)
in Interphase Cells Journal of Cell Science 121: 2087-2096
(2008).
270.Kato, A., Tanaka, M., Yamamoto, M., Asai, R., Sata, T., Nishiyama,
Y. and Kawaguchi, Y.
Identification of a physiological phosphorylation site of the
Herpes simplex virus 1-encoded protein kinase Us3 which regulates
its optimal catalytic activity in vitro and influences its function
in infected cells.Journal of Virology 82: 6172-6189 (2008).
271.Nawa A, Luo C, Zhang L, Ushjima Y, Ishida D, Kamakura M, Fujimoto
Y, Goshima F, Kikkawa F, Nishiyama Y. Non-engineered, naturally
oncolytic herpes simplex virus HSV1 HF-10: applications for cancer
gene therapy. Curr Gene Ther 8: 208-221 (2008).
272.Kimura H, Ito Y, Suzuki R, Nishiyama Y.
Measuring Epstein-Barr virus (EBV) load: the significance and
application for each EBV-associated disease. Rev Med Virol
18 : 305-319 (2008).
273.Funahashi Y, Hattori R, Kinukawa T, Kimura H, Nishiyama Y,
Gotoh M.
Conversion from mycophenolate mofetil to mizoribine for patients
with positive polyomavirus type BK in urine. Transplant Proc
40 (7): 2268-2270 (2008).
274.Sato Y, Shirata N, Kudoh A, Iwahori S, Nakayama S, Murata
T, Isomura H, Nishiyama Y, Tsurumi T. Expression of Epstein-Barr
virus BZLF1 immediate-early protein induces p53 degradation independent
of MDM2, leading to repression of p53-mediated transcription.
Virology 388(1):204-211(2009).
275.Wada K, Mizoguchi S, Ito Y, Kawada J, Yamauchi Y, Morishima
T, Nishiyama Y, Kimura H.
Multiplex real-time PCR for the simultaneous detection of herpes
simplex virus, human herpesvirus 6, and human herpesvirus 7. Microbiol
Immunol 53(1):22-29 (2009).
276. Mizuno T, Sugiura S, Kimura H, Ando Y, Sone M, Nishiyama
Y, Nakashima T.
Detection of cytomegalovirus DNA in preserved umbilical cords
from patients with sensorineural hearing loss. Eur Arch Otorhinolaryngol
266 (3):351-355 (2009).
277. Sato, Y., Kamura, T., Shirata, N., Murata, T., Kudoh, A.,
Iwahori, S., Nakayama, S., Isomura, H., Nishiyama, Y., and Tsurumi,
T. Degradation of phosphorylated p53 by viral protein-ECS E3 ligase
complex.PLoS Pathogens 7:e1000530 (2009). 278.
Kimura, H., Miyake, K., Yamauchi, Y., Nishiyama, K., Iwata, S.,
Iwatsuki, K., Gotoh, K., Kojima, S., Ito, Y., and Nishiyama, Y.
Identification of Epstein-Barr virus-infected lymphocyre subtypes
by flow cytometric in situ hybridization in EBV-associated lymphoproliferative
diseases. Journal of Infectious Diseases 200:1078-1087 (2009).
279. Ushijima, Y., Goshima, F., Kimura, H., and Nishiyama, Y.
Herpes simplex virus type 2 tegument protein UL56 relocalizes
ubiquitin ligase Nedd4 and has a role in transport and/or release
of virions.Virology Journal 6:168 (2009).
280. Morimoto, T., Arii, J., Tanaka, M., Sata, T., Akashi, H.,
Yamada, M., Nishiyama, Y., Uema, M., and Kawaguchi, Y. Differences
in the regulatory and functional effects of the US3 protein kinase
activities of herpes simplex virus 1 and 2.Journal of Virology
83: 11624-11634 (2009).
281. Ishikawa, T., Yamada, H., Oyamada, A., Goshima, F., Nishiyama,
Y., and Yoshikai, Y. Protective role of Fas-FasL signaling in
lethal infection with herpes simplex virus type 2 in mice. Journal
of Virology 83: 11777-11783 (2009).
282. Iwata, S., Wada, K., Tobita, S., Gotoh, K., Ito, Y., Demachi-Okamura,
A., Shimizu, N., Nishiyama, Y., and Kimura, H. Quantitative analysis
of Epstein-Barr virus (EBV)-related gene expression in patients
with chronic active EBV infection. Journal of General Virology
91: 42-50 (2010).
283. Ishida, D., Nawa, A., Tanino, T., Goshima, F., Luo, C. H.,
Iwaki, M., Kajiyama, H., Shibata, K., Yamamoto, E., Ino, K., Tsurumi,
T., Nishiyama, Y., and Kikkawa, F. Enhanced cytotoxicity with
a novel system combining the paclitaxel-2ﾕ-ethylcarbonate produrug
and an HSV amplicon with attenuated replication-competent virus,
HF10 as a helper virus.Cancer Letters, in press (2010).
284. Funahashi, Y., Iwata, S., Ito, Y., Kojima, S., Yoshikawa,
T., Hattori, R., Gotoh, M., Nishiyama, Y., and Kimura, H. Multiplex
real-time PCR assay for quantifying BK polyomavirus, JC polyomavirus,
and adenovirus DNA simultaneously. Journal of Clinical Microbiology,
in press (2010).
285. Esaki, S., Goshima, F., Katsumi, S., Watanabe, D., Ozaki,
N., Murakami, S., Nishiyama, Y.Apoptosis induction after herpes
simplex virus infection differs according to cell type in vivo.Archieves
of Virology, 155: 1235-1245 (2010).
286. Fujiwara, S., Nawa, A., Luo, CH., Kamakura, M., Goshima,
F., Kondo, C., Kiyono, T., Kikkawa, F., Nishiyama, Y. Carrier
cell-based delivery of replication- competent HSV-1 mutants enhances
antitumor effect for ovarian cancer. Cancer Gene Therapy,
in press (2010).
287. Gotoh, K., Ito, Y., Iwata, S., Nishiyaa, Y., Nakamura, T.,
Kaneko, K., Kiuchi, T., Ando, H., Kimura, H. Immunologic and virologic
analyses in pediatric liver transplant recipients with chronic
high Epstein-Barr virus loads. Journal of Infectious Disease 202: 461-469 (2010).
288. Ushijima Y, Luo C, Kamakura M, Goshima F, Kimura H, Nishiyama
Y. Herpes simplex virus UL56 interacts with and regulates the
Nedd4-family ubiquitin ligase Itch.Virology Journal. 2010
Aug 3;7(1):179.
289. Iwata S, Yano S, Ito Y, Ushijima Y, Gotoh K, Kawada JI, Fujiwara
S, Sugimoto K, Isobe Y, Nishiyama Y, Kimura H. Bortezomib induces
apoptosis in T lymphoma cells and natural killer lymphoma cells
independent of epstein-barr virus infection. Int J Cancer.
2011, in press (2011).
290. Esaki S, Kitoh J, Katsumi S, Goshima F, Kimura H, Sawat M,
Yamao K, Watanabe N, Nonoguchi N, Nakamura T, Coffin RS, Miyatake
S, Nishiyama Y, Murakami S. Hepatocyte growth factor incorporated
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291. Esaki S, Goshima F, Kimura H, Ikeda S, Katsumi S, Kabaya
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292. Nakao A, Kasuya H, Sahin TT, Nomura N, Kanzaki A, Misawa
M, Shirota T, Yamada S, Fujii T, Sugimoto H, Shikano T, Nomoto
S, Takeda S, Kodera Y, Nishiyama Y. A phase I dose-escalation
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293. Ohta A, Nishiyama Y. Mitochondria and viruses. Mitochondrion.
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原著（和文）
1. 下方 薫、西山 幸廣、伊藤 康彦、木村 吉延、永田 育也、飯田 光夫、祖父江 逸郎
ＨＶＪの中枢神経系に対する病原性
臨床とウイルス ４：６８−７０（１９７６）
2. 下方 薫、西山 幸廣、伊藤 康彦、木村 吉延、永田 育也
突発性難聴のウイルス学的検討
耳鼻と臨床 ２２：８８９−９９２（１９７６）
3. 伊藤 康彦、下方 薫、西山 幸廣、永田 育也
インターフェロン インデューサー
代謝 １４：３１−３９（１９７７）
4. 西山 幸廣
単純ヘルペスウイルス：ウイルスＤＮＡポリメラーゼを中心に
蛋白質・核酸・酵素 ３０：１０８１−１０９５（１９８５）
5. 西山 幸廣
ウイルス核酸合成阻害剤
阻害剤研究法（日高 弘義 編、共立出版、１９８５）
6. 永井美之、西山幸廣
ウイルスの増殖
医系微生物学 （加藤 延夫編、 朝倉書店）（１９８７）
7. 西山 幸廣
カエルヘルペスウイルス
微生物学辞典 （日高 醸編、技報堂）
8. 西山 幸廣
ヘルペスウイルス特異酵素とその阻害剤
ウイルス ３７：５５―７０（１９８７）
9. 西山 幸廣
ＮＡＴＯ研究会議 “Molecular Basis of Viral Replication”
蛋白質・核酸・酵素 ３２：２７４―２７７（１９８７）
10. 西山 幸廣
ウイルス感染症の化学療法
医系微生物学（加藤延夫編、朝倉書店）
11. 西山 幸廣
ウイルス学と遺伝子操作
医系微生物学（加藤延夫編、朝倉書店）
12. 西山 幸廣
ポックスウイルス科
医系微生物学（加藤延夫編、朝倉書店）
14. 西山 幸廣
サイトメガロウイルス剤開発の現況
モダンメディスン １７：８４―８６（１９８８）
15. 西山 幸廣
ヘルペスウイルスのＤＮＡ複製
日本臨床 ４７：３１―３６（１９８９）
16. 西山 幸廣
ヌクレオシドアナログ以外の抗ヘルペス剤開発の動向
日本臨床 ４７：１５０―１５４（１９８９）
17. 西山 幸廣
単純ヘルペスウイルス：増殖と病原性の分子的基盤
蛋白質・核酸・酵素 ３５：９０５−９１７（１９９０）
18. 西山 幸廣
単純ヘルペスウイルス：神経病原性の分子的基盤
F acial Nerve Research of Japan 10: 1-6 (1990)
19. 西山 幸廣
抗ウイルス剤：現況と研究の動向
現代医学 ３８：３０２−３１２（１９９０）
20. 西山 幸廣
新しい抗ヘルペス剤の開発
医学の歩み １５２：５９７（１９９０）
21. 西山 幸廣
ヘルペスウイルス増殖阻害物質とその標的
ウイルス ４０：２３−２５（１９９０）
22. 西山 幸廣
単純ヘルペスウイルスの発癌機構
癌とウイルス （服部 信、 川名 尚編、 メディカルビュー社）
23. 西山 幸廣
ヘルペスウイルス：吸着 侵入 増殖
臨床と微生物 １８：３４３−３４８（１９９１）
24. 西山 幸廣
抗サイトメガロウイルス化学療法剤
代謝 ２８：２２７−２３４（１９９１）
25. 西山 幸廣
抗ヘルペス薬の基礎
化学療法の基礎 ８：１９１６−１９２３（１９９２）
27. 西山 幸廣
単純ヘルペスウイルス感染の分子機構
日本医事新報 ３５５１：１３０−１３１（１９９２）
28. 西山 幸廣
抗ウイルス剤の標的としてのヘルペスウイルス特異酵素
抗ウイルス化学療法研究の進歩（小野 克彦編、抗ウイルス化学療法研究会）（１９９３）
29. 西山 幸廣
単純ヘルペスウイルスの感染様式、水痘帯状ほう疹ウイルスの感染様式
ヘルペスの診療Ｑ＆Ａ （新村 真人編、中外医学社）（１９９３）
30. 伊藤 康彦、西山 幸廣
各種インターフェロンのDNAおよびRNAウルスに対する効果
基礎と臨床 ２７：４５９ー４６２（１９９３）
31. 西山 幸廣
ウイルスＤＮＡ合成酵素
生物薬科学実験講座 第５巻 遺伝子 （広川書店）
32. 西山 幸廣
細菌とウイルスの増殖の違い
日本医事新報 ３７２６：１３５―１３６（１９９５）
33. 西山 幸廣
ヘルペスウイルス遺伝子の機能：増殖と病原性の分子的基盤
現代医学 ４３：５１―５７（１９９５）
34. 小野信和、西山幸廣
ウイルス核酸複製の阻害 ―ヘルペスウイルスを中心として―
Mebio １２：５６―６３（１９９５）
35. 西山 幸廣
学会記 ウイルス学会
日本医事新報 ３７４３：３２―３４（１９９５）
36. 西山 幸廣
ヘルペスウイルスとその感染症―最近の話題―
名古屋内科医会会報 ９6：５１―５６（１９９５）
37. 西山 幸廣
ヘルペスウイルスと感染症
標準微生物学 第６版（医学書院）（１９９６）
38. 西山 幸廣
ウイルス感染症の化学療法、DNA型ウイルス 他
医系微生物学 第２版（朝倉書店）（１９９６）
39. 西山 幸廣
ヘルペスウイルス病原性発現の分子機構
LIP 第２巻 （菜根出版）（１９９６）
40. 渡辺大輔、西山幸廣
単純ヘルペスウイルス感染症の予防と対策
化学療法の領域 １３：１６５３―１６５８（１９９７）
41. 西山 幸廣
ウイルス
人間の生物学 （名古屋大学出版）（１９９７）
42. 西山 幸廣
非必須遺伝子
メデイカル用語ライブラリーウイルス・細菌 （羊土社）（１９９７）
43. 西山 幸廣
インターフェロン
メデイカル用語ライブラリーウイルス・細菌 （羊土社）（１９９７）
44. 西山 幸廣
侵入脱殻阻害剤
メデイカル用語ライブラリーウイルス・細菌 （羊土社）（１９９７）
45. 西山 幸廣
ウイルス核酸阻害剤
メデイカル用語ライブラリーウイルス・細菌 （羊土社）（１９９７）
46. 西山 幸廣
ヘルペスウイルスアクセサリー遺伝子
実験医学 「ウイルス最前線 」（羊土社）（１９９７）
47. 西山 幸廣
ヒトサイトメガロウイルスの増殖と遺伝子機能
日本臨床 ５６：２９―３５（１９９８）
48. 西山 幸廣
抗ウイルス剤
微生物学実習提要（東大医科研学友会編、丸善）（１９９８）
49．西山 幸廣
HSVの生活環
遺伝子治療ハンドブック(エヌ・テイー・エフ)
50．粕谷英樹、西山幸廣 他
膵臓 １４：１２７−１３９（１９９９）
51．稲垣匡子、西山幸廣
ヘルペスウイルス感染と生体防御
医学のあゆみ ｢生体応答学の新展開｣（１９９９）
52．村田貴之、西山幸廣
アルファヘルペスウイルスの増殖機構
日本臨床 ５８：１７―２２（２０００）
53．大黒徹、西山幸廣
ヒトサイトメガロウイルスの遺伝子機能と増殖機構
LIP第４巻 (菜根出版)（２０００）
54．永井美之、西山幸廣
ウイルス感染の成立と病原性を決定する諸要因
現代医学の基礎１１｢感染と生体防御｣(岩波書店)（２０００）
55．西山幸廣、渡辺大輔
単純ヘルペスウイルスとその感染症概論
神経内科 ５４：３９９―４０６（２００１）
56．西山幸廣、村田貴之、山内洋平
単純ヘルペスウイルス遺伝子産物の機能
ウイルス ５１： ２９―３６（２００１）
57．西山幸廣
宿主との関係
ワンポイントウイルス学(南山堂)（２００１）
58．西山幸廣、吉川哲史
ヘルペスウイルス科
ワンポイントウイルス学(南山堂)（２００１）
59．西山幸廣
ヘルペスウイルス科と感染症
標準微生物学第7版 (医学書院)（２００２）
60．西山幸廣、川口寧
ヘルペスウイルスの医学的利用―遺伝子治療と癌治療への応用―
ウイルス ５３：１５５―１６２（２００３）
61．西山幸廣、吉川哲史
感染症の遺伝子学：単純ヘルペスウイルス１、２
日本臨床「新世紀の感染症学」６１：５６８―５７４（２００３）
62．吉川哲史、西山幸廣
感染症の遺伝子学：水痘帯状ウイルス
日本臨床「新世紀の感染症学」６１：５７５―５８１（２００３）
63．西山幸廣、森勇
ヘルペスウイルスとその感染症ー現状と展望ー
日本医事新報 ４１２９：５―１２（２００３）
64．西山 幸廣
ヘルペスウイルス感染症の克服
ウイルス ５３：８１―８５（２００３）
65．西山幸廣
ヘルペスウイルス科と感染症
標準微生物学第９版 (医学書院)（２００５）
66．川口寧、西山幸廣
ヘルペスウイルスの増殖機構とヘルペスウイルスベクターの開発
VIRUS REPORT 2：35-43 （２００５）
67．森勇、西山幸廣
単純ヘルペスウイルス
微生物感染学(南山堂)（２００５）
68．西山幸廣
序文
日本臨床「ヘルペスウイルス学」（２００６）
69．西山幸廣
ヘルペスウイルス研究の歴史
70. 西山幸廣(編集)
「ヘルペスウイルス学」 日本臨床社 (2006) pp１〜６９６
71. 西山幸廣 内科学第9版(朝倉書店) (2006)
「単純ヘルペスウイルス、サイトメガロウイルス、EBウイルス」他
72。野本明男、西山幸廣(編集)
「ウイルス研究の現在と展望」 共立出版社 (2007) pp１〜２６１
73. 西山幸廣
DNAウイルス研究の流れと展望
蛋白質・核酸・酵素52：1050−1055 (2007)
74．那波明宏、西山幸廣 他
卵巣癌のウイルス療法
産婦人科治療 94:1121-1123 (2007)
75. 西山幸廣(監訳) メルクマニュアル第9版 (日経メディカル社) (2007)
「感染症 ウイルス性疾患」
76．西山幸廣、五島典
単純ヘルペスウイルスを利用した癌に対するウイルス療法
ウイルス 57：57−66（2007）
日本臨床「ヘルペスウイルス学」（２００６）
77．西山幸廣
拡大するウイルスの世界
ゲノム医学 8：167-172（2008）
78．西山幸廣
ヘルペスウイルス感染症の克服
実験医学 26：2884-2890（2008）
79. 牛島洋子、西山幸廣
KEY WORD感染症 （先端医学社） （2008）「欠損ウイルス」
80. 西山幸廣
標準微生物学第10版 (医学書院) (2009)「ヘルペスウイルス科と感染症」
81．西山幸廣
ウイルス病原性の発現機構
臨床検査 53：9‐16（2009）
82．牛島洋子、西山幸廣
単純ヘルペスウイルスの増殖と病原性発現機構
蛋白質・核酸・酵素 54:953-960（2009）
83．西山幸廣
病原体の細胞内動態
実験医学 27:1510-1513（2009）
84．藤原多子、那波明宏、五島典、西山幸廣
弱毒化単純ヘルペスウイルスを用いた悪性腫瘍治療
メディカルバイオ （2010）
85．河野慎一、駱晨虹、五島典、西山幸廣
単純ヘルペスウイルスHF10を用いたがん治療法の開発
臨床とウイルス （2010）