ORIGINAL PAPERS
Validity of a tablet computer version of the Japanese
Orthopaedic Association hip disease evaluation questionnaire:
a pilot study
Yasuhiko Takegami, Taisuke Seki, Ayumi Kaneuji, Akinobu Nakao, Yukiharu Hasegawa
and Naoki Ishiguro
pg(s) 237 - 244
<Abstract> - < PDF >
The Japanese Orthopaedic Association hip disease evaluation questionnaire (JHEQ) was established
as a new patient-reported outcome for patients with hip disease. We developed a JHEQ application beta
version for tablet computers. The application has a slider system to input visual analogue scale (VAS)
measurements. The purposes of this study were 1) to test whether the VAS that was acquired from this
slider system was equal to the value recorded on paper and 2) to evaluate the validity and agreement of
the JHEQ tablet version. A total of 57 patients were analyzed in the study (mean age, 60.2 years; range,
29–81 years). They received either the paper-and-pencil version (paper version) or the tablet computer
version (tablet version). To evaluate the validity of the tablet version, we analyzed differences in the
VAS and total scores between the paper version and tablet computer version. In addition, we calculated
Cronbach’s alpha, the intraclass correlation coefficient (ICC), and the Pearson’s correlation coefficient (CC).
The VAS scores in the tablet version were significantly lower than those in the paper version (22.3 ± 5.4
vs. 17.0 ± 4.5 and 28.1 ± 6.1 vs. 23.5 ± 5.3, respectively; all P < 0.05). Values of Cronbach’s alpha, the
ICC, and the CC among subscales ranged from 0.90 to 0.95. In conclusion, the total JHEQ score on the
tablet computer beta version was in agreement with the score on the paper version. However, the VAS
on the tablet version, which used a slider bar system, proved unreliable.
Evaluation of radiation exposure dose at double-balloon
endoscopy for the patients with small bowel disease
Asuka Nagura, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura, Kohei Funasaka,
Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima, Shuji Koyama, Tomoki Hinami,
Hidemi Goto and Yoshiki Hirooka
pg(s) 245 - 253
<Abstract> - < PDF >
Double-balloon endoscopy (DBE) is useful for the diagnosis and treatment of small bowel diseases.
Although fluoroscopy is used to confirm the position of endoscope at DBE, the endoscopist does not
have the knowledge with regard to the radiation exposure dose. In this study, we evaluated the absorbed
dose during DBE in patients with suspected or established small bowel diseases. This was a retrospective
study in which the estimated fluoroscopic radiation absorbed doses loaded on the small bowel and skin
were determined according to the data of the referential X-ray experiment with a human body phantom.
The subjects were 415 DBEs preformed in total. The mean small bowel absorbed doses on antegrade and
retrograde DBEs were 42.2 and 53.8 mGy, respectively, showing that the organ dose applied in retrograde
DBE was significantly higher (P<0.0001). The mean skin absorbed doses of them were 79.2 and 101.0
mGy, respectively, showing that the dose was also significantly higher on retrograde DBE (P<0.0001).
Of 27 cases who were applied endoscopic balloon dilation, the mean fluoroscopy time was 16.0 minutes,
and mean small bowel and skin absorbed doses were 121.9 and 228.9 mGy, respectively. In conclusion,
endoscopist should be careful for reducing the organ exposure dose at DBE, particularly for the lower
abdominal region.
Treatment protocol based on assessment of
clot quality during endovascular thrombectomy for
acute ischemic stroke using the Trevo stent retriever
Kojiro Ishikawa, Tomotaka Ohshima, Masahiro Nishihori, Tasuku Imai, Shunsaku Goto,
Taiki Yamamoto, Toshihisa Nishizawa, Shinji Shimato and Kyozo Kato
pg(s) 255 - 265
<Abstract> - < PDF >
The optional endovascular approach for acute ischemic stroke is unclear. The Trevo stent retriever can
be used as first-line treatment for fast mechanical recanalization. The authors developed a treatment protocol
for acute ischemic stroke based on the assessment of clot quality during clot removal with the Trevo.
This prospective single-center study included all patients admitted for acute ischemic stroke between July
2014 and February 2015, who underwent emergency endovascular treatment. According to the protocol,
the Trevo was used for first-line treatment. Immediately after the Trevo was deployed, the stent delivery
wire was pushed to open the stent by force (ACAPT technique). Clot quality was assessed on the basis
of the perfusion status after deployment of the Trevo; continued occlusion or immediate reopening either
reoccluded or maintained after the stent retriever had been in place for 5 min. If there was no obvious
clot removal after the first pass with the Trevo, according to the quality of the clot, either a second pass
was performed or another endovascular device was selected. Twelve consecutive patients with acute major
cerebral artery occlusion were analyzed. Thrombolysis in cerebral infarction score 2b and 3 was achieved
in 11 patients (91.7%) and 9 (75%) had a good clinical outcome after 90 days based on a modified
Rankin scale score ≤ 2. Symptomatic intracranial hemorrhage occurred in 1 patient (8.3%). The overall
mortality rate was 8.3%. Endovascular thrombectomy using the Trevo stent retriever for first-line treatment
is feasible and effective.
Carpal tunnel syndrome associated with Kienböck disease
Takaaki Shinohara, Ryogo Nakamura, Etsuhiro Nakao and Hitoshi Hirata
pg(s) 267 - 273
<Abstract> - < PDF >
We retrospectively reviewed 12 patients (3 men and 9 women, with a mean age of 72 years) who were
surgically treated for carpal tunnel syndrome associated with Kienböck disease. All patients except 1 were
incidentally diagnosed with Kienböck disease and had little or no wrist pain. Radiographic tests revealed
advanced Kienböck disease in all patients. Intraoperative findings indicated that the site of maximum
compression on the median nerve was located at the level of the carpal tunnel inlet in 11 patients, and the
volar dislocated fragment of the lunate was located proximally adjacent to the floor of the carpal tunnel
inlet. This disorder is most prevalent in elderly women, and even advanced Kienböck disease can present
without wrist pain. Our findings suggest that palmar protrusion of the lunate may be the primary cause
of carpal tunnel syndrome associated with Kienböck disease.
Influence of the treatment schedule on the physicians’
decisions to refer bone metastases patients for palliative
radiotherapy: a questionnaire survey of physicians
in various specialties
Tetsuo Saito, Ryo Toya, Akiko Semba, Tomohiko Matsuyama and Natsuo Oya
pg(s) 275 - 284
<Abstract> - < PDF >
We investigated whether the treatment schedule influences physicians’ decisions to refer their patients
for radiotherapy. We presented a questionnaire to 104 physicians in various specialties at three hospitals. It
included three hypothetical patients with uncomplicated painful bone metastasis: patients with an expected
life span of one year (case 1), 6 months (case 2), and 2 months (case 3). The physicians were asked
whether they would refer their patients for radiotherapy when a radiation oncologist presented three different
treatment schedules: a short (8 Gy/1 fraction/1 day)-, a medium (20 Gy/5 fractions/1 week)-, and a long
(30 Gy/10 fractions/2 weeks) schedule. We used Cochran’s Q-test to compare the percentage of physicians
across the three schedules and a mixed-effect logistic model to identify predictors of the selection of only
the one-day schedule. Of the 104 physicians, 68 (65%) responded. Of these, 37 (54%), 27 (40%), and 26
(38%) chose to refer patients for radiotherapy when the short-, medium-, and long schedules, respectively,
were proposed in case 1 (p = 0.14). These numbers were 44 (65%), 29 (43%), and 15 (22%) for case 2
(p < 0.001), and 59 (87%), 12 (18%), and 1 (1%) for case 3 (p < 0.001). Hypothetical patient and the
physicians’ years of practice and perspective regarding side effects were independently predictive of the
selection of only the one-day schedule. In conclusion, the treatment schedule influenced the physicians’
decisions to refer patients for radiotherapy.
Exploring the factor on sensory motor function of upper
limb associated with executive function in communitydwelling
older adults
Hiroyuki Hayashi, Daiki Nakashima, Hiroka Matsuoka, Midori Iwai, Shugo Nakamura,
Ayumi Kubo and Naoki Tomiyama
pg(s) 285 - 291
<Abstract> - < PDF >
Exercise, such as cardiovascular fitness training, has been shown to have utility in improving executive
function but is difficult for older adults with low mobility to perform. Accordingly, there is interest in the
development of regimens other than high mobility exercises for older adults with low mobility. The aim of
the present study was to evaluate the association between sensory motor function of the upper limb and
executive function in community-dwelling older adults. A cross-sectional study was conducted in 57 righthanded,
independent, community-dwelling older adults. Sensory motor function of upper limb, including
range of motion, strength, sensation, finger dexterity, and comprehensive hand function was measured in
both hands. Executive function was assessed using the Delta Trail Making Test. Multiple regression analysis
indicated the finger dexterity of the non-dominant hand as independently associated with executive function
(β = –0.414, P < 0.001). The findings of the present study may facilitate the development of exercise
regimens for improving executive function that are more suitable for older adults with limited physical
fitness levels. As this was a cross-sectional study, further studies are required to validate the efficacy of
non-dominant finger dexterity training for improving executive function in older adults.
Reduced molecular size and altered disaccharide composition
of cerebral chondroitin sulfate upon Alzheimer’s pathogenesis
in mice
Zui Zhang, Shiori Ohtake-Niimi, Kenji Kadomatsu and Kenji Uchimura
pg(s) 293 - 301
<Abstract> - < PDF >
Alzheimer’s disease (AD) is a progressive disorder leading to cognitive impairment and neuronal
loss. Cerebral extracellular accumulation and deposition of amyloid ß plaques is a pathological hallmark
of AD. Chondroitin sulfate (CS) is an extracellular component abundant in the brain. CS is a sulfated
glycosaminoglycan covalently attached to a core protein, forming chondroitin sulfate proteoglycan. The
structure of CS is heterogeneous with sulfation modification and elongation of the chain. The structural
diversity of CS allows it to play various roles in the brain. Increasing evidence has shown that CS
promotes aggregation of amyloid ß peptides into higher-order species such as insoluble amyloid ß fibrils.
Difficulties in the structural analysis of brain CS, as well as its heterogeneity, limit the study of potential
roles of CS in AD pathology. Here we established a microanalysis method with reversed-phase ion-pair
high performance liquid chromatography and found that CS in the brains of Tg2576 AD model mice show
a lower molecular size and an increased ratio of CS-B motif di-sulfated disaccharide. Our findings provide
insight into the structural changes of cerebral CS upon Alzheimer’s pathogenesis.
Nogo receptor 1 is expressed in both primary cultured glial
cells and neurons
Junichi Ukai, Shiro Imagama, Tomohiro Ohgomori, Zenya Ito, Kei Ando,
Naoki Ishiguro and Kenji Kadomatsu
pg(s) 303 - 311
<Abstract> - < PDF >
Nogo receptor (NgR) is common in myelin-derived molecules, i.e., Nogo, MAG, and OMgp, and plays
important roles in both axon fasciculation and the inhibition of axonal regeneration. In contrast to NgR’s
roles in neurons, its roles in glial cells have been poorly explored. Here, we found a dynamic regulation
of NgR1 expression during development and neuronal injury. NgR1 mRNA was consistently expressed in
the brain from embryonic day 18 to postnatal day 25. In contrast, its expression significantly decreased
in the spinal cord during development. Primary cultured neurons, microglia, and astrocytes expressed
NgR1. Interestingly, a contusion injury in the spinal cord led to elevated NgR1 mRNA expression at the
injury site, but not in the motor cortex, 14 days after injury. Consistent with this, astrocyte activation by
TGFb1 increased NgR1 expression, while microglia activation rather decreased NgR1 expression. These
results collectively suggest that NgR1 expression is enhanced in a milieu of neural injury. Our findings
may provide insight into the roles of NgR1 in glial cells.
Relationship between prostate volume changes and treatment
duration of neoadjuvant androgen deprivation during
intensity-modulated radiation therapy for Japanese patients
with prostate cancer
Masashi Tomida, Kuniyasu Okudaira, Takeshi Kamomae, Hiroshi Oguchi,
Yoshikazu Miyake, Kazuo Yoneda and Yoshiyuki Itoh
pg(s) 313 - 321
<Abstract> - < PDF >
The application of neoadjuvant androgen deprivation (NAD) in prostate cancer leads to a reduction in
prostate volume, and the trends in volume reduction differ according to the treatment duration of NAD.
A reduction in volume during external beam radiation therapy may lead to the exposure of normal tissues
to an unexpected dose. In fact, prostate volume reductions have primarily been reported in European
and American institutions. Although the prostate volume of Japanese patients is known to be small, the
trends in prostate volume change during radiation therapy remain unclear. In the present study, we aimed
to evaluate the changes in prostate volume of Japanese patients during intensity-modulated radiation
therapy (IMRT) with NAD. Nineteen Japanese patients with prostate cancer underwent IMRT with NAD.
Kilovoltage computed tomography (CT) images were obtained for treatment planning and verification of
the treatment position for each treatment fraction. The patients were divided into 3 groups based on the
duration of NAD, as follows: NAD < 3 months (short NAD: S-NAD), 3 months ≤ NAD < 6 months
(middle NAD: M-NAD), and NAD ≥ 6 months (long NAD: L-NAD). The prostate volume reductions
at the 36th treatment fraction, relative to the planning CT, were 7.8%, 2.0%, and 1.7% for the S-NAD,
M-NAD, and L-NAD groups, respectively. Prostate volume shrunk greater in the S-NAD group than in
the M-NAD and L-NAD groups; this finding was consistent with those of previous studies. The prostate
volume changes in Japanese patients were smaller compared to those in European and American patients.
CASE REPORTS
COX-2 inhibitory NSAID-induced multiple stenosis in the
small intestine diagnosed by double-balloon endoscopy
Yasuaki Ueno, Masanao Nakamura, Osamu Watanabe, Takeshi Yamamura,
Kohei Funasaka, Eizaburo Ohno, Ryoji Miyahara, Hiroki Kawashima,
Hidemi Goto and Yoshiki Hirooka
pg(s) 323 - 328
<Abstract> - < PDF >
The patient was a 72 year old man who had been given non-steroidal anti-inflammatory drug (NSAID)
for two years. He repeatedly developed small intestinal ileus; therefore, he underwent several imaging
examinations, but the cause was not identified. He subsequently underwent a double-balloon endoscopy
(DBE). The membranous stenoses were detected in the jejunum, and the biopsy specimens were taken during
the DBE. The membranous stenoses in the gastrointestinal tract were characteristic of NSAID–induced
enteropathy, and he was endoscopically and histopathologically diagnosed with NSAID-induced small
intestinal disorder. NSAID administration was withdrawn, and the balloon dilation was conducted for small
intestinal stenosis. After that, no small intestinal ileus developed again. Some studies were conducted on
the mechanism of NSAID-induced small intestinal dysfunction, but the drug that was administered to the
patient was a highly selective NSAID for cyclooxygenase (COX)-2, and there are few studies that reported
a dysfunctional mechanism induced by this drug. In the tissue sampled by DBE, apoptotic bodies were
found; therefore, it was suggested that the stenoses in this case were caused by the COX-2 inhibitor from
the relationship between COX-2 inhibition and apoptosis. Further studies are necessary to investigate the
mechanism of NSAID enteropathy.
Scleroderma renal crisis during intravenous
cyclophosphamide pulse therapy for complicated interstitial
lung disease was successfully treated with angiotensin
converting enzyme inhibitor and plasma exchange
Norihiro Nagamura and Seikon Kin
pg(s) 329 - 334
<Abstract> - < PDF >
Systemic sclerosis (SSc) is a multiorgan disorder involving the skin, heart, lungs, kidneys, and intestines.
Progressive interstitial lung disease (ILD) is a serious complication in SSc patients, and cyclophosphamide
(CYC) is the only recommended therapy for this condition; however, its clinical effectiveness is not
sufficient. Scleroderma renal crisis (SRC) is a rare complication, characterized by acute renal failure and
progressive hypertension. Angiotensin-converting-enzyme inhibitor (ACE-i) is a widely accepted therapy
for SRC. We report an SSc patient with SRC and progressive ILD who underwent treatment with CYC
and successful treatment with ACE-i and plasma exchange (PE). SRC and ILD are significant contributors
to morbidity and mortality among SSc patients, and the therapy for these disorders is of great interest
to rheumatologists. This study presents the possibility of favorable effects of PE for SSc-associated ILD
and SRC.