Nagoya Journal of Medical Science

Decreased activities of jejunal mucosal enzymes, i.e. lactase, sucrase, maltase and gamma-glutamyl transpeptidase were found in rats with experimental blind loop syndrome.
The peroral administration of Kanamycin induced both reduction in fecal fat excretion and restoration of enzyme activities in rats with the blind loop syndrome. Similar effects of Kanamycin on fecal fat excretion and jejunal mucosal enzyme activities were also recognized in unoperated rats.
There was an inverse relationship between fecal fat excretion and activities of those enzymes which are mainly located in the brush border of the enterocyte. From these results, significance of jejunal brush border enzymes in the blind loop syndrome was discussed.

Immunoglobulin levels (lgA, IgG and IgM) were examined in 41 cases of malignant lymphoma, consisting of 14 cases of Hodgkin's disease, 23 cases of reticulum cell sarcoma, and 4 cases of lymphosarcoma. Data were summarized as follows.
1) Levels of the 3 classes of immunoglobulins tend to divert from the normal with aggravation of the clinical course. An improvement of the clinical course, on the other hand, tends to bring the immunoglobulin values to the normal range.
2) Low level of IgA in Hodgkin's disease and sarcoma group may be closely related to improvement in the lymphatic tissues, rather than due to treatment.
3) Statistically correlated IgA or IgG levels to pheripherallymphocyte counts lower than 1,500/cmm were also observed.

Postoperative management of patients with primary hyperparathyroidism requires to determine whether the operation has succeeded or not in early postoperative days as well as to deal with postoperative hypoparathyroidism. Twenty three surgically managed patients with primary hyperparathyroidism were studied.
Attention was focused on the time course of postoperative serum calcium levels and postoperative hypocalcemic signs. The following conclusion were obtained.
When the surgery was successful, the serum total calcium levels fell·to normal range within 48 hours, then below normal range and gradually returned to normal. It took about one to three months for the serum calcium levels to return to normal.
Severe postoperative hypocalcemic signs were observed in those patients with extensive bone disease and high serum alkaline phosphatase activities, in those where initial hypocalcemic signs appeared within 24 hours after surgery, and in those where plasma total calcium levels continued to decrease after the fourth postoperative day.
Calcium should be administered only to patients with severe hypocalcemic signs or to those with postoperative congestive heart failure.
The second exploration should be performed without delay when the fluctuating hypercalcemia persists after the operation.